NFL Week 1 Odds & Betting Lines
The 2026-27 NFL odds board just got a mid-May jolt, with the league releasing the schedule. For the first time ever, play opens on a Wednesday.
And it's an immediate Super Bowl rematch. New England Patriots vs. Seattle Seahawks kicks off NFL Week 1 odds, and three more big prime-time matchups follow on the 16-game slate.
Below are NFL odds Week 1 from an array of sportsbooks, along with bookmaker insights on the most notable matchups. Looking for more NFL odds? Check out our extensive list of NFL player prop odds and NFL futures.
(Feature image: Kevin Jairaj/Imagn Images)
Week 1
2026 NFL Week 1 Odds
Notable Matchups/Line Moves
LATEST UPDATE: It's the evening of May 14, and the NFL just released the entire 2026-27 schedule. So not only are NFL Week 1 odds on the board, so too are numbers for numerous matchups – marquee and otherwise – in subsequent weeks.
You can't do much better than a Super Bowl rematch to start. Although hopefully New England Patriots vs. Seattle Seahawks is more entertaining and closer this time around. The Seahawks beat the Patriots 29-13 to finish off the 2025-26 season.
The rematch is at 8:20 p.m. ET Wednesday, Sept. 9, in Seattle and airing on NBC. The Seahawks opened as 3.5-point home favorites at DraftKings Sportsbook, a point below the closing Super Bowl spread.
"They're betting the Seahawks early, and that trend will most likely continue," DraftKings director of sportsbook operations Johnny Avello said.
On Thursday, Sept. 10, it's San Francisco 49ers vs. Los Angeles Rams, two more teams that were Super Bowl contenders last season. The Rams opened -2.5 (-120) for an 8:35 p.m. ET kickoff from Melbourne, Australia, in the first of five games this season on Netflix.
The next prime-time matchup has actually seen movement very early on in NFL Odds Week 1. At 8:20 p.m. ET Sunday, Sept. 13, on NBC, the Dallas Cowboys visit the NFC East rival New York Giants.
DraftKings opened Dallas -1.5 and is up to -2.5 (-105).
"Bettors like the Cowboys in a number of games and also regular-season wins. The Cowboys' win total has changed from 8.5 to 9.5," Avello said.
An AFC West clash is the first Monday night game: Denver Broncos vs. Kansas City Chiefs, at 8:15 p.m. ET Monday, Sept. 14, on ESPN. The Chiefs opened -2.5 (-120) at DraftKings.
Whether or if that line adjusts will depend largely on the progress of Patrick Mahomes. The Chiefs QB tore an ACL and MCL in a December loss to the Los Angeles Chargers. Mahomes is currently expected to be a go by Week 1.
"We anticipate Mahomes will play, so -3 would be the ceiling," Avello said.
NFL Week 1 Opening Odds
DraftKings Sportsbook's opening odds for NFL Week 1: 👇
WEDNESDAY, SEPT. 9
- Patriots vs. Seahawks (-3.5)
THURSDAY, SEPT. 10
- 49ers vs. Rams (-2.5)
SUNDAY, SEPT. 13
- Buccaneers vs. Bengals (-3.5)
- Falcons vs. Steelers (-3)
- Bills (-1.5) vs. Texans
- Ravens (-3.5) vs. Colts
- Browns vs. Jaguars (-7)
- Jets vs. Titans (-3)
- Saints vs. Lions (-7)
- Bears (-2.5) vs. Panthers
- Dolphins vs. Raiders (-3)
- Cardinals vs. Chargers (-11.5)
- Commanders vs. Eagles (-5.5)
- Packers (-1.5) vs. Vikings
- Cowboys (-1.5) vs. Giants
MONDAY, SEPT. 14
- Broncos vs. Chiefs (-2.5)
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Odds current as of June 03, 2026
NFL Super Bowl Odds
2026-27 Super Bowl odds are in constant motion. Here are each teams' opening odds at BetMGM to hoist the Lombardi Trophy in February.
- Seattle Seahawks +800
- Los Angeles Rams +900
- Baltimore Ravens +1200
- Buffalo Bills +1200
- Green Bay Packers +1400
- Philadelphia Eagles +1400
- Detroit Lions +1500
- Kansas City Chiefs +1500
- Los Angeles Chargers +1500
- New England Patriots +1500
- San Francisco 49ers +1700
- Denver Broncos +2000
- Houston Texans +2000
- Jacksonville Jaguars +2000
- Chicago Bears +2500
- Cincinnati Bengals +3000
- Dallas Cowboys +3000
- Indianapolis Colts +4000
- Tampa Bay Buccaneers +4000
- Minnesota Vikings +5000
- Washington Commanders +5000
- Atlanta Falcons +6600
- New York Giants +6600
- Pittsburgh Steelers +8000
- Carolina Panthers +10000
- Tennessee Titans +10000
- Cleveland Browns +15000
- Los Angeles Raiders +15000
- New Orleans Saints +15000
- Arizona Cardinals +25000
- Miami Dolphins +25000
- New York Jets +25000
For more, check out VegasInsider's complete Super Bowl Futures Odds Report.
NFL Betting Odds Resources
There are a bunch of ways you can bet on the NFL. Not only do you have the usual moneyline betting and point spread betting, but you also have totals (over/under) betting, prop betting, first-half bets, second-half bets and more.
No matter what you're looking for, we have it for you at VegasInsider. If you're looking for the best odds and want to place a bet, you should check out our selection of the best sportsbooks in the US. In particular, our bet365 bonus code can provide a variety of useful betting options.
Take a look at the odds for every game this week above and also check out our slew of NFL Odds pages below:
Monday Night Football Odds | Thursday Night Football Odds | Super Bowl Promotions | Best NFL Betting Sites | NFL Player Prop Bets | Best NFL Parlays and Picks
Updated on: 2026-06-03
Updated on 6/3/26
🏆 Popular Super Bowl Markets & Other NFL Futures
- Super Bowl 61
- Win Totals
- Playoff (Yes-No)
- Most Valuable Player
- Rookie of the Year
- Player of the Year
- Comeback Player
- Coach of the Year
🏉 NFL Conference Winner Markets
🥇 NFL Division Winner Markets
- NFC East Division Winner Odds
- NFC West Division Winner Odds
- NFC South Division Winner Odds
- NFC North Division Winner Odds
- AFC East Division Winner Odds
- AFC West Division Winner Odds
- AFC South Division Winner Odds
- AFC North Division Winner Odds
How To Bet On The NFL
Betting on the NFL can seem simple, but there are some nuances to be aware of. Make sure to check out our football betting guide and how to bet on the Super Bowl pages for more in-depth information outside of the bet types listed below:
Point Spread Betting
Spread betting gets a bit more advanced than just "who's going to win", and requires you to have a solid knowledge of how a team might perform. For example, let's say Green Bay is listed as +3.5 (-110). That means that, in order for your bet to pay out on those -110 odds, the Packers need to either win the game or not lose by 4 points or more.
Moneyline Betting
Whether you're betting the Super Bowl futures or betting on a team to win tonight's game, you're probably looking at a moneyline. This is typically a straightforward "who's going to win" bet:
EXAMPLE: SEATTLE (+800) TO WIN THE 2026-27 SUPER BOWL
Let's say the Seahawks are listed as an 8/1 betting choice to win the Super Bowl. If you wager $100 on Seattle to win Super Bowl 61, and the Seahawks capture the championship, then you would win $800 (8/1 x 100).
Your online betting account would then credit your account $900, which includes your win and stake ($100). However, if you're benefiting from a bonus betting credit, that doesn't count towards your stake, and you'll only receive your win.
The DraftKings Sportsbook promo code is a good choice for a welcome offer to secure before you start betting moneylines!
Totals Betting (Over/Under)
If you're betting totals, and you're probably seeing a pattern here, you're betting on the total number of points scored. These bet types are pretty logically named, no? Anyway, if you're betting on a Packers vs. Bears matchup and the total is set at over or under 48.5, that means that oddsmakers don't expect the cumulative score earned by both teams to exceed 48. If it does, and you bet the OVER, you get a payout. If it doesn't and you bet the UNDER, you get a payout.
Parlay Betting
Parlay betting is not for the feint of heart, as we've said: it requires you to string together anywhere from 3-12 (and sometimes more) bets for a bigger payout. The only trick? Every single leg has to hit, otherwise you lose it all.
We're also seeing one-game or single game parlays on the board lately, and that's in large part due to the advent of live betting.
Prop Betting and Live Betting
Prop betting is a form of casual bet that doesn't really have to do with the outcome of a game. For example, you can have the more technical prop bets like "player to exceed X passing yards before the half" or "team to intercept before the quarter is finished". You can also have less technical bets like "color of Gatorade dumped on the coach", "will the mascot trip down the stairs today", or any number of novelty bets.
Throw in the fact that legal, online betting can be done from a mobile device, and live betting becomes possible: that's where you can place prop bets, including parlaying them together in single-game parlays, as the game is happening. Exciting times we live in!
Best NFL Betting Sites
We've reviewed some of the top NFL sportsbooks in the country and their exclusive promotions available for new and existing users. Check out our sportsbook reviews, learn about the Fanatics Sportsbook promo code, and read sections on providers to get all the information you need to get online and bet legally, including promos and bonuses to get you off on the right foot!
What Teams Can I Bet On?
VegasInsider Open and Consensus
NFL Opening Line
One of the best features on the NFL Vegas Odds is the Open Line. This numbers consists of the first betting line received from one of our preferred sportsbooks. The opening line varies depending on the sportsbook, but the figure provides a clear-cut rating as determined by the oddsmakers. If you’re betting on the NFL or any other sport, it’s a great idea to view the open line first.
VI Consensus NFL Line
The VegasInsider.com Consensus NFL Line is just as important as the Open Line and also a key resource on odds platform. The Consensus column could be called a “Median Line”, since it shows the most consistent number provided by the sportsbooks on VegasInsider.com. The consensus line will be the same as the open line but once the wagers start coming in, this number is often different than the openers.
NFL Odds FAQ
Why Would You Bet On Negative NFL Odds?
Negative NFL odds indicate that the bet is the favorite, which would lead to a lower payout. Positive NFL odds indicate an underdog bet, leading to a higher payout. Sometimes, taking a bet on the favorite makes sense if you don't see a clear path for the underdog to upset the expected result.
How Are NFL Odds Determined?
NFL odds are determined by professional oddsmakers employed by the top sportsbooks. Online betting odds usually reflect what is determined by oddsmakers at the nation's top casinos, many of which are in Las Vegas.
How Do I Read NFL Odds?
Reading the NFL odds is simple. Whether you're looking at totals bets, props, moneylines, or spread betting, the negative number indicates the favorite (and a lower payout) and the positive number indicates the underdog (and a higher payout). When betting the spread, there are also smaller numbers indicating the point difference, and for totals, the total number of expected points.
Who Are The Favorites To Win The NFL?
The Seattle Seahawks won Super Bowl 60 and opened as the +800 favorite to repeat in Super Bowl 61.
Super Bowl 61 Opening Odds
- Seattle Seahawks +800
- Los Angeles Rams +900
- Buffalo Bills +1200
- Baltimore Ravens +1200
- Philadelphia Eagles +1400
- Green Bay Packers +1400
- More NFL Futures Odds
How Can I Win Betting On The NFL?
NFL betting is very involved and the lines are some of the most accurate in the market. As always, there's no guarantee for a winning strategy, but looking for value in less popular player props, underdogs with an improving record, and of course using the expert resources here at VegasInsider are a good start.
What Is A Point Spread In NFL Betting?
A point spread in NFL betting looks at the performance of a team regardless if they win or lose. A losing team can still win a point spread bet by "covering" the spread, and earning at least as many points as is set by the spread.
