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2026 March Madness Second Round Odds: Lines, Spreads, Betting Trends

Patrick Everson
Patrick Everson Sports Betting Expert
14 minute read
2026 March Madness Second Round Odds: Lines, Spreads, Betting Trends

March Madness odds for the second round are on the board and taking action, with half of the games now complete.

No. 1 seeds Duke and Michigan have already advanced to the Sweet 16, Fellow No. 1s Arizona and Florida are part of Sunday's festivities in 2026 NCAA Tournament odds, with another eight-game slate on tap.

Here's everything you need to know about college basketball odds for 2026 March Madness Second Round games: opening lines, spreads and betting trends. Check back for updates throughout the week, and use our BetMGM bonus code to get the most out of your action.

(Feature image: Wendell Cruz/Imagn Images)

March Madness Second Round Odds

Midwest Region

Texas Tech vs. Alabama Odds

TTU @ ALA Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
Texas Tech Red Raiders 809 Texas Tech
-1.5 -120 +0.5 -120 +0.5 -115 +0.5 -115 +0.5 -110 +0.5 -118 +1.5 -140 +2.5 -125 +1.5 -141 +1.5 -115  
Alabama Crimson Tide 810 Alabama
+1.5 even -0.5 -110 -0.5 -115 -0.5 -115 -0.5 -110 -0.5 -106 -1.5 +105 -2.5 -110 -1.5 +110 -1.5 -105  
Final
Texas Tech Red Raiders 809 Texas Tech
o166.5 -110 o77.5 -115 o76.5 -115 o77.5 -105 o77 -115 o77.5 -111 o77.5 -115 o75.5 -115 o77.5 -117 o164.5 -108  
Alabama Crimson Tide 810 Alabama
u166.5 -110 u77.5 -115 u76.5 -115 u77.5 -125 u77 -115 u77.5 -115 u77.5 -110 u75.5 -115 u77.5 -109 u164.5 -112  
Final
Texas Tech Red Raiders 809 Texas Tech
-130 -110 -105 -105 even -110 -105 N/A -107 -102  
Alabama Crimson Tide 810 Alabama
+110 -120 -125 -125 -120 -110 -120 N/A -122 -118  
Final
Texas Tech Red Raiders 809 Texas Tech
-1.5 -120 N/A N/A N/A +1.5 -135 +0.5 -114 -1.5 -130 N/A +1.5 -132 +1.5 -115  
Alabama Crimson Tide 810 Alabama
+1.5 even N/A N/A N/A -1.5 +105 -0.5 -110 +1.5 -145 N/A -1.5 even -1.5 -105  
Final
Texas Tech Red Raiders 809 Texas Tech
o166.5 -110 N/A N/A N/A N/A o43.5 -118 N/A N/A N/A o164.5 -108  
Alabama Crimson Tide 810 Alabama
u166.5 -110 N/A N/A N/A N/A u43.5 -108 N/A N/A N/A u164.5 -112  
Final
Texas Tech Red Raiders 809 Texas Tech
-130 N/A N/A N/A N/A N/A -105 -115 -103 -102  
Alabama Crimson Tide 810 Alabama
+110 N/A N/A N/A N/A N/A -130 -115 -130 -118  
  • Opening point spread: Texas Tech -1.5
  • Opening moneyline: Texas Tech -130/Alabama +110
  • Opening total: Over/Under 166.5 points scored
  • Time: 9:45 p.m. ET Sunday (TBS)

LATEST UPDATE: With 15 minutes or so until tipoff, Alabama is -1 (-105) at The SuperBook. On Sunday night, this matchup opened at pick 'em, and since then, both teams spent time at -1. In just the past half-hour, the line moved from pick to 'Bama -1.

"This is probably the best game of the day. We've got more tickets on Texas Tech and bigger bets on Alabama. We need Texas Tech for just a little. It's not that big of a decision," SuperBook VP John Murray said.

The total is at 164.5, mirroring the opener, up from the 163.5 low point and down from the 165 high.

OPENING ODDS UPDATE: No. 4 seed Alabama (24-9 SU/15-18 ATS) let trendy underdog Hofstra stick around well into the second half. But with a 71-66 lead, the Crimson Tide went on punishing 14-0 run en route to a 90-70 victory as 11.5-point favorites.

Likewise, No. 5 seed Texas Tech (23-10 SU/18-15 ATS) was in a tight game vs. No. 12 Akron, with the Red Raiders up 64-60 midway through the second half. But Tech outscored Akron 26-10 the rest of the way in a 90-70 victory giving 6.5 points.

That ended the Red Raiders' 0-3 SU and ATS skid.

DraftKings opened Texas Tech -1.5 (-120) vs. Alabama in NCAA Tournament odds for the second round. In the first few minutes, the juice adjusted to Texas Tech -1.5 (-105), and that's where the line is at 8 p.m. ET Friday.

Early spread ticket count is dead even at DK, but 78% of early spread money is on Alabama.

The total dipped from 166.5 to 155.5 right out of the gate. Tickets are almost even, while 57% of early money is on the Under.

West Region

Utah State vs. Arizona Odds

USU @ ARIZ Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
Utah State Aggies 823 Utah State
+12.5 -110 N/A N/A N/A N/A N/A N/A +3.5 -125 N/A +11.5 -105  
Arizona Wildcats 824 Arizona
-12.5 -110 N/A N/A N/A N/A N/A N/A -3.5 -105 N/A -11.5 -115  
Final
Utah State Aggies 823 Utah State
o155.5 -110 o72.5 -115 o72.5 -120 o72.5 -120 o73 -115 o73.5 -111 o72.5 -110 o73.5 -120 o72.5 -112 o153.5 -112  
Arizona Wildcats 824 Arizona
u155.5 -110 u72.5 -115 u72.5 -110 u72.5 -110 u73 -115 u73.5 -115 u72.5 -115 u73.5 -110 u72.5 -114 u153.5 -108  
Final
Utah State Aggies 823 Utah State
+625 +290 +300 +280 +310 +285 +325 N/A +300 +550  
Arizona Wildcats 824 Arizona
-950 -400 -450 -395 -400 -375 -450 N/A -455 -800  
Final
Utah State Aggies 823 Utah State
+12.5 -110 N/A N/A N/A N/A N/A N/A +1.5 -180 N/A +11.5 -105  
Arizona Wildcats 824 Arizona
-12.5 -110 N/A N/A N/A N/A N/A N/A -1.5 +140 N/A -11.5 -115  
Final
Utah State Aggies 823 Utah State
o155.5 -110 N/A N/A N/A N/A o43.5 -104 N/A N/A N/A o153.5 -112  
Arizona Wildcats 824 Arizona
u155.5 -110 N/A N/A N/A N/A u43.5 -122 N/A N/A N/A u153.5 -108  
Final
Utah State Aggies 823 Utah State
+625 N/A N/A N/A N/A N/A N/A +105 N/A +550  
Arizona Wildcats 824 Arizona
-950 N/A N/A N/A N/A N/A N/A -140 N/A -800  
  • Opening point spread: Arizona -12.5
  • Opening moneyline: Arizona -950/Utah State +625
  • Opening total: Over/Under 155.5 points scored
  • Time: 7:50 p.m. ET Sunday (truTV)

LATEST UPDATE: With 30 minutes or so until tipoff, Arizona is laying 11.5 points in BetMGM's March Madness odds Second Round market. That's where the number opened and where it's been most of the past 48 hours, save for a couple brief trips to -12.5.

"Utah State any which way possible is what we will need," BetMGM trading manager Tristan Davis said.

The total is at its low of 153.5, after opening at 156.5 and initially ticking up to 157.5 (Under -115).

OPENING ODDS UPDATE: No. 9 seed Utah State (29-6 SU/17-18 ATS) rallied from an early second-half 10-point deficit to beat Villanova 86-76 in Friday's first round. The Aggies, 1.5-point favorites, sealed it with a 15-3 run to end the game.

Utah State is on a 4-0 SU and ATS upswing.

No. 1 seed Arizona (33-2 SU/21-14 ATS) didn't give No. 16 Long Island any room to breathe. The Wildcats led 53-29 at halftime and cruised to a 92-58 victory laying a massive 30.5 points.

Arizona takes a 10-0 SU run (6-4 ATS) into the Round of 32.

Just before 8 p.m. ET Friday, DraftKings opened Arizona -12.5 vs. Utah State in March Madness odds for the second round. By Saturday afternoon, the Wildcats advanced to -12.5 (-118).

Early spread tickets solidly favor Arizona, at 76%. But the Wildcats are getting just 55% of early spread money, as of 1:30 p.m. ET Saturday.

DraftKings' total has seen significant early movement. The number opened at 155.5, quickly climbed to 157.5, then made its way down to 154. 5 Over (-115) by Saturday afternoon. The Over is getting 63% of tickets/58% of money so far.

Completed Games

West Region

Miami vs. Purdue Odds

MIA @ PUR Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
Miami (FL) Hurricanes 817 Miami (FL)
+8.5 -118 +4.5 -120 +4.5 -120 +4.5 -115 +4.5 -115 +4.5 -120 +4.5 even +1.5 -130 +5.5 -122 +8.5 -118  
Purdue Boilermakers 818 Purdue
-8.5 -102 -4.5 -110 -4.5 -110 -4.5 -115 -4.5 -105 -4.5 -104 -4.5 -125 -1.5 -105 -5.5 -105 -8.5 -102  
Final
Miami (FL) Hurricanes 817 Miami (FL)
o152.5 -110 o68.5 -115 o68.5 -110 o68.5 -115 o68.5 -115 o68.5 -104 o68.5 -115 o70.5 -105 o68.5 -106 o146.5 -115  
Purdue Boilermakers 818 Purdue
u152.5 -110 u68.5 -115 u68.5 -118 u68.5 -115 u68.5 -115 u68.5 -122 u68.5 -120 u70.5 -115 u68.5 -121 u146.5 -105  
Final
Miami (FL) Hurricanes 817 Miami (FL)
+300 +210 +185 +210 +222 +198 +210 N/A +225 +300  
Purdue Boilermakers 818 Purdue
-380 -280 -250 -280 -278 -250 -260 N/A -305 -380  
Final
Miami (FL) Hurricanes 817 Miami (FL)
+8.5 -118 N/A N/A N/A +3.5 -115 +3.5 -110 +3.5 -115 +3.5 +105 +3.5 -112 +8.5 -118  
Purdue Boilermakers 818 Purdue
-8.5 -102 N/A N/A N/A -3.5 -115 -3.5 -114 -3.5 -115 -3.5 -130 -3.5 -120 -8.5 -102  
Final
Miami (FL) Hurricanes 817 Miami (FL)
o152.5 -110 N/A N/A N/A N/A o41.5 -102 N/A N/A N/A o146.5 -115  
Purdue Boilermakers 818 Purdue
u152.5 -110 N/A N/A N/A N/A u41.5 -125 N/A N/A N/A u146.5 -105  
Final
Miami (FL) Hurricanes 817 Miami (FL)
+300 N/A N/A N/A N/A N/A +200 +200 +190 +300  
Purdue Boilermakers 818 Purdue
-380 N/A N/A N/A N/A N/A -275 -275 -265 -380  
  • Opening point spread: Purdue -7.5
  • Opening moneyline: Purdue Miami
  • Opening total: Over/Under 149.5 points scored
  • Time: 12:10 p.m. ET Sunday (CBS)

LATEST UPDATE: Purdue is a 7.5-point favorite in BetMGM's March Madness odds for the second round. That matches Friday's opener, though on Saturday, the Boilermakers made brief trips to -6.5 (-118) and -8.5 (-102).

"We will be rooting for Miami. It's probably about 2/1 money on Purdue, spread and moneyline," BetMGM trading manager Christian Cipollini said.

The total is at 147.5, which is where it's been much of the past two days, after opening at 149.5. Still, Cipollini said the Under is preferred in today's first tipoff.

Purdue (28-8 SU/16-20 ATS) is coming off a 104-71 pounding of Queens as a 25.5-point first-round favorite. The Boilermakers are 5-0 SU in the postseason, including a four-game run through the Big Ten Tournament.

Miami (26-8 SU/19-15 ATS) dumped Missouri 80-66 giving 1.5 points Friday.

High Point vs. Arkansas Odds

HP @ ARK Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
High Point Panthers 785 High Point
+12.5 -110 +6.5 -110 +7.5 -125 +7.5 -125 +7.5 -115 +6.5 -104 +7.5 -110 +6.5 -130 +7.5 -113 +12.5 -105  
Arkansas Razorbacks 786 Arkansas
-12.5 -110 -6.5 -120 -7.5 -105 -7.5 -105 -7.5 -105 -6.5 -120 -7.5 -110 -6.5 even -7.5 -113 -12.5 -115  
Final
High Point Panthers 785 High Point
o170.5 -110 o82 -115 o82.5 -110 o82.5 -110 o82 -115 o82.5 -113 o82.5 -110 o79.5 -105 o82.5 -112 o171.5 -110  
Arkansas Razorbacks 786 Arkansas
u170.5 -110 u82 -115 u82.5 -120 u82.5 -120 u82 -115 u82.5 -113 u82.5 -115 u79.5 -125 u82.5 -115 u171.5 -110  
Final
High Point Panthers 785 High Point
+950 +290 +310 +310 +345 +310 +350 N/A +350 +600  
Arkansas Razorbacks 786 Arkansas
-1650 -400 -475 -445 -455 -420 -475 N/A -480 -900  
Final
High Point Panthers 785 High Point
+12.5 -110 N/A N/A N/A +5.5 -110 +5.5 -104 +5.5 -115 +6.5 -105 +5.5 -117 +12.5 -105  
Arkansas Razorbacks 786 Arkansas
-12.5 -110 N/A N/A N/A -5.5 -120 -5.5 -120 -5.5 -115 -6.5 -125 -5.5 -114 -12.5 -115  
Final
High Point Panthers 785 High Point
o170.5 -110 N/A N/A N/A N/A o46.5 -125 N/A N/A N/A o171.5 -110  
Arkansas Razorbacks 786 Arkansas
u170.5 -110 N/A N/A N/A N/A u46.5 -102 N/A N/A N/A u171.5 -110  
Final
High Point Panthers 785 High Point
+950 N/A N/A N/A N/A N/A +260 +280 +255 +600  
Arkansas Razorbacks 786 Arkansas
-1650 N/A N/A N/A N/A N/A -375 -400 -375 -900  
  • Opening point spread: Arkansas -12.5
  • Opening moneyline: Arkansas -1650/High Point +950
  • Opening total: Over/Under 170.5 points scored
  • Time: 9:45 p.m. ET Saturday (truTV/TBS)

LATEST UPDATE: Just over an hour before tipoff, Arkansas is laying 12.5 points in The SuperBook's March Madness Second Round odds. The Razorbacks opened -11.5 and initially dipped to -11, but the line got to -12 Friday night and -12.5 in the past hour.

"At this point, we're gonna have a lot of parlays going to Arkansas spread and Arkansas moneyline," SuperBook VP John Murray said. "We're gonna be rooting for High Point. It's not like a spread-cover would be meaningless. But High Point outright would be the nuts."

The total is at 170.5, just off the 171 high point, but up from the 169 opener and 168.5 low point of Thursday.

"We took some pretty substantial bets on Over 169.5. We'll definitely want the Under," Murray said.

OPENING ODDS UPDATE: No. 12 seed High Point (31-4 SU/16-16 ATS) sprung the first big upset of the NCAA Tournament. The Panthers closed as 10.5-point underdogs vs. No. 5 Wisconsin and eked out an 83-82 victory.

Chase Johnston, primarily a 3-point shooter, made his first 2-pointer of the season count. Johnston got a breakaway layup to give High Point the 83-82 edge with 11 seconds left, and it held up for the Panthers' 15th consecutive win.

No. 4 seed Arkansas (27-8 SU/23-12 ATS) didn't have nearly as close a contest vs. No. 13 Hawaii. The Razorbacks led 54-36 at recess and rolled to a 97-78 win giving 14.5 points.

Early Thursday evening, Arkansas opened -12.5 vs. High Point in DraftKings' March Madness odds for the second round. Within 15 minutes, the Razorbacks dipped to -11.5.

Early spread ticket count is dead even, while 61% of early spread money is on underdog High Point, as of 9:30 p.m. ET Thursday.

DraftKings' total is already down to 168.5 from a 170.5 opener, although 61% of tickets/65% of dollars are on the Over.

South Region

Vanderbilt vs. Nebraska Odds

VAN @ NEB Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
Vanderbilt Commodores 781 Vanderbilt
-1.5 -105 -1 -110 -0.5 -120 -0.5 -125 -0.5 -110 -0.5 -112 -1.5 -105 -1.5 +105 -1.5 +104 -1.5 -115  
Nebraska Cornhuskers 782 Nebraska
+1.5 -115 +1 -120 +0.5 -110 +0.5 -105 +0.5 -110 +0.5 -112 +1.5 -125 +1.5 -125 +1.5 -132 +1.5 -105  
Final
Vanderbilt Commodores 781 Vanderbilt
o147.5 -110 o68.5 -115 o68.5 -120 o68.5 -120 o68.5 -115 o68.5 -108 o68.5 -105 o68.5 -110 o68.5 -106 o146.5 -108  
Nebraska Cornhuskers 782 Nebraska
u147.5 -110 u68.5 -115 u68.5 -110 u68.5 -110 u68.5 -115 u68.5 -118 u68.5 -120 u68.5 -110 u68.5 -121 u146.5 -112  
Final
Vanderbilt Commodores 781 Vanderbilt
-115 -130 -135 -125 -125 -120 -130 N/A -129 -135  
Nebraska Cornhuskers 782 Nebraska
-105 even even -105 +105 -102 even N/A +102 +114  
Final
Vanderbilt Commodores 781 Vanderbilt
-1.5 -105 N/A N/A N/A -1.5 +105 -1.5 -106 -1.5 even -1.5 +105 -1.5 even -1.5 -115  
Nebraska Cornhuskers 782 Nebraska
+1.5 -115 N/A N/A N/A +1.5 -135 +1.5 -118 +1.5 -135 +1.5 -140 +1.5 -134 +1.5 -105  
Final
Vanderbilt Commodores 781 Vanderbilt
o147.5 -110 N/A N/A N/A N/A o38.5 -120 N/A N/A N/A o146.5 -108  
Nebraska Cornhuskers 782 Nebraska
u147.5 -110 N/A N/A N/A N/A u38.5 -106 N/A N/A N/A u146.5 -112  
Final
Vanderbilt Commodores 781 Vanderbilt
-115 N/A N/A N/A N/A N/A -135 -130 -132 -135  
Nebraska Cornhuskers 782 Nebraska
-105 N/A N/A N/A N/A N/A -130 even even +114  
  • Opening point spread: Vanderbilt -1.5
  • Opening moneyline: Vanderbilt -118/Nebraska -102
  • Opening total: Over/Under 147.5 points scored
  • Time: 8:45 p.m. ET Saturday (TNT)

LATEST UPDATE: With tipoff 30 minutes out, Vanderbilt is -1.5 in The SuperBook's March Madness odds for the second round. The Commodores opened -1 and got as high as -2.5 a couple times, most recently in just the past hour.

"It looks like we're gonna need Nebraska. But there are a lot of tickets on both sides," SuperBook VP John Murray said. "It's one of the more evenly bet games of the day."

Favorites are currently on a 21-0 SU run dating to Thursday night games.

"We'll be rooting for the 'dog, which is scary. Do 'dogs ever win?" Murray said, half-jokingly. "But it's not nearly as big of a decision as others we were sweating today."

The total is at 146.5, up a tick from this morning's 146 low, but down from the 147.5 opener. Murray said there's not much of a decision on the total.

OPENING ODDS UPDATE: No. 4 seed Nebraska is playing in its ninth NCAA Tournament. On Thursday, the Huskers finally got their first Big Dance victory. Nebraska (27-6 SU/18-15 ATS) hammered Troy 76-47 laying 13.5 points.

No. 5 seed Vanderbilt (27-8 SU/18-17 ATS) led McNeese State by just three at halftime, 38-35. But the Commodores went on to a 78-69 victory, while falling short of the cover as 12.5-point favorites.

Vandy then opened -1.5 vs. Nebraska in DraftKings' NCAA Tournament Second Round odds. Within 20 minutes Thursday evening, the Commodores advanced to -2.5.

Vanderbilt is getting 57% of early spread tickets/82% of early spread dollars.

The total adjusted from 147.5 flat to 147.5 (Over -115), with 55% of tickets on the Over/85% of money on the Under in the early going.

VCU vs. Illinois Odds

VCU @ ILL Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
VCU Rams 779 VCU
+10.5 -110 +6.5 -115 +6.5 -110 +6.5 -115 +6.5 -105 +6.5 -116 --6.5 -120 +6.5 -105 +6.5 -107 +12.5 -115  
Illinois Fighting Illini 780 Illinois
-10.5 -110 -6.5 -115 -6.5 -120 -6.5 -115 -6.5 -115 -6.5 -108 +-6.5 -120 -6.5 -115 -6.5 -120 -12.5 -105  
Final
VCU Rams 779 VCU
o153.5 -110 o70.5 -115 o70.5 -120 o70.5 -110 o70.5 -115 o70.5 -111 o71.5 -110 o71.5 -115 o70.5 -108 o151.5 -105  
Illinois Fighting Illini 780 Illinois
u153.5 -110 u70.5 -115 u70.5 -110 u70.5 -120 u70.5 -115 u70.5 -115 u71.5 -120 u71.5 -115 u70.5 -118 u151.5 -115  
Final
VCU Rams 779 VCU
+425 +280 +300 +280 +310 +285 -475 N/A +320 +525  
Illinois Fighting Illini 780 Illinois
-575 -390 -450 -395 -400 -375 -425 N/A -480 -750  
Final
VCU Rams 779 VCU
+10.5 -110 N/A N/A N/A +5.5 -115 +5.5 -104 --5.5 -105 +5.5 even +5.5 -107 +12.5 -115  
Illinois Fighting Illini 780 Illinois
-10.5 -110 N/A N/A N/A -5.5 -115 -5.5 -120 +-5.5 -125 -5.5 -130 -5.5 -125 -12.5 -105  
Final
VCU Rams 779 VCU
o153.5 -110 N/A N/A N/A N/A o43.5 -111 N/A N/A N/A o151.5 -105  
Illinois Fighting Illini 780 Illinois
u153.5 -110 N/A N/A N/A N/A u43.5 -115 N/A N/A N/A u151.5 -115  
Final
VCU Rams 779 VCU
+425 N/A N/A N/A N/A N/A +260 +250 +265 +525  
Illinois Fighting Illini 780 Illinois
-575 N/A N/A N/A N/A N/A -325 -350 -385 -750  
  • Opening point spread: Illinois -10.5
  • Opening moneyline: Illinois -575/VCU +425
  • Opening total: Over/Under 153.5 points scored
  • Time: 7:50 p.m. ET Saturday (CBS)

LATEST UPDATE: Ninety minutes before tipoff, Illinois is laying 11.5 points in March Madness odds at BetMGM. That matches Thursday's opening number, with the line toggling between -11.5/-10.5 multiple times, at various juice.

"We will want VCU to win or get as close as possible. We need this run of favorites to end," BetMGM trading manager Tristan Davis said.

The total is at 150.5, up from this morning's 149.5 low point, but down from the 152.5 (Under -115) opener. Per usual, BetMGM needs the Under tonight.

OPENING ODDS UPDATE: No. 11 seed Virginia Commonwealth (28-7 SU/18-17 ATS) bounced a college basketball blueblood in Thursday's first round. And in huge comeback fashion.

The Rams were 2.5-point underdogs vs. No. 6 North Carolina and trailed by 19 with 15 minutes remaining. But VCU ultimately forged a 75-75 tie to force overtime, then won 82-78.

VCU has won seven in a row and is 17-1 SU in its last 18 games.

No. 3 seed Illinois (25-8 SU/17-16 ATS) put the clamps on No. 14 Penn. The Fighting Illini coasted to a 64-46 victory, but failed to cash as hefty 25.5-point favorites.

Late Thursday night, DraftKings opened Illinois -10.5 vs. VCU. Early Friday morning, the Illini advanced to -11.5 (-105), where the number remains at midnight Friday.

VCU is landing 55% of early spread bets, while early spread money is almost dead even.

DraftKings' total opened at 153.5 late Thursday night and went directly to 151.5 within an hour. That's where it remains late Friday night, although the Over is netting 68% of early bets/82% of early money.

East Region

Kansas vs. St. John's Odds

SJU @ KU Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
St. John's Red Storm 821 St. John's
-2.5 -110 -1.5 -125 -1.5 -120 -1.5 -125 -1.5 -120 -1.5 -118 -1.5 -125 -7.5 -115 -1.5 -124 -3.5 -112  
Kansas Jayhawks 822 Kansas
+2.5 -110 +1.5 -105 +1.5 -110 +1.5 -105 +1.5 even +1.5 -106 +1.5 -110 +7.5 -110 +1.5 -103 +3.5 -108  
Final
St. John's Red Storm 821 St. John's
o143.5 -115 o67.5 -115 o67.5 -110 o67.5 -115 o67.5 -115 o68.5 -104 o67.5 -115 o67.5 -120 o67.5 -114 o144.5 -112  
Kansas Jayhawks 822 Kansas
u143.5 -105 u67.5 -115 u67.5 -120 u67.5 -115 u67.5 -115 u68.5 -122 u67.5 -110 u67.5 -115 u67.5 -112 u144.5 -108  
Final
St. John's Red Storm 821 St. John's
-148 -150 -160 -154 -145 -150 +105 N/A -157 -175  
Kansas Jayhawks 822 Kansas
+124 +120 +120 +120 +122 +122 +125 N/A +123 +145  
Final
St. John's Red Storm 821 St. John's
-2.5 -110 N/A N/A N/A -1.5 -115 -0.5 -120 -1.5 -110 -1.5 +130 -1.5 -110 -3.5 -112  
Kansas Jayhawks 822 Kansas
+2.5 -110 N/A N/A N/A +1.5 -115 +0.5 -104 +1.5 -120 +1.5 -170 +1.5 -121 +3.5 -108  
Final
St. John's Red Storm 821 St. John's
o143.5 -115 N/A N/A N/A N/A o38.5 -102 N/A N/A N/A o144.5 -112  
Kansas Jayhawks 822 Kansas
u143.5 -105 N/A N/A N/A N/A u38.5 -125 N/A N/A N/A u144.5 -108  
Final
St. John's Red Storm 821 St. John's
-148 N/A N/A N/A N/A N/A +120 -115 -159 -175  
Kansas Jayhawks 822 Kansas
+124 N/A N/A N/A N/A N/A +125 -115 +120 +145  
  • Opening point spread: St. John's -2.5
  • Opening moneyline: St. John's -148/Kansas +124
  • Opening total: Over/Under 142.5 points scored
  • Time: 5:15 p.m. ET Sunday (CBS)

LATEST UPDATE: BetMGM has St. John's -3.5 (-105) in March Madness Second Round odds, 45 minutes before tipoff. That matches the Thursday night opener, after which the Red Storm made a brief trip to -4.5 (-102), then early Friday fell back to -2.5 (-120).

St. John's has been -3.5 at various juice since Friday morning.

"We'll need Kansas. A lot more action on St. John's, which is a little bit surprising, with New York [customers] not being able bet on New York teams," BetMGM trading manager Christian Cipollini said. "We'd prefer Kansas to win outright."

The total is at 144.5, again matching the opener, though even today, it's toggled between 143.5/144.5/145.5. Cipollini said BetMGM prefers the Under.

OPENING ODDS UPDATE: No. 5 seed St. John's (29-6 SU/20-15 ATS) scored the first 13 points of the game and led No. 12 Northern Iowa 24-6 midway through the first half. It was academic from there, as the Red Storm rolled 79-53 laying 10.5 points Friday.

St. John's is 7-0 SU/6-1 ATS in its last seven games.

No. 4 seed Kansas (24-10 SU/20-14 ATS) blew most of a 38-18 halftime lead vs. No. 13 seed California Baptist. But the Jayhawks held on for a 68-60 victory as 14.5-point favorites.

DraftKings opened St. John's -2.5 and went to -3.5 in relatively short order Friday night. Check back Saturday for updates on March Madness second-round odds on this matchup.

TCU vs. Duke Odds

TCU @ DUKE Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
TCU Horned Frogs 777 TCU
+12.5 -112 +6.5 -120 +6.5 -110 +7.5 -125 +7 -105 +7.5 -118 -7.5 -115 +4.5 -105 +7.5 -120 +12.5 -118  
Duke Blue Devils 778 Duke
-12.5 -108 -6.5 -110 -6.5 -120 -7.5 -105 -7 -115 -7.5 -106 +7.5 -120 -4.5 -125 -7.5 -107 -12.5 -102  
Final
TCU Horned Frogs 777 TCU
o138.5 -110 o65 -115 o65.5 -115 o64.5 -120 o65.5 -115 o64.5 -120 o66.5 -115 o66.5 -115 o65.5 -120 o140.5 -110  
Duke Blue Devils 778 Duke
u138.5 -110 u65 -115 u65.5 -115 u64.5 -110 u65.5 -115 u64.5 -106 u66.5 -105 u66.5 -115 u65.5 -107 u140.5 -110  
Final
TCU Horned Frogs 777 TCU
+575 +300 +310 +300 +310 +350 +325 N/A +330 +575  
Duke Blue Devils 778 Duke
-850 -425 -475 -425 -400 -480 -500 N/A -500 -850  
Final
TCU Horned Frogs 777 TCU
+12.5 -112 N/A N/A N/A +4.5 -105 +5.5 -120 +5.5 -115 +6.5 -125 +5.5 -115 +12.5 -118  
Duke Blue Devils 778 Duke
-12.5 -108 N/A N/A N/A -4.5 -125 -5.5 -104 -5.5 -115 -6.5 -110 -5.5 -115 -12.5 -102  
Final
TCU Horned Frogs 777 TCU
o138.5 -110 N/A N/A N/A N/A o40.5 -100 N/A N/A N/A o140.5 -110  
Duke Blue Devils 778 Duke
u138.5 -110 N/A N/A N/A N/A u40.5 -128 N/A N/A N/A u140.5 -110  
Final
TCU Horned Frogs 777 TCU
+575 N/A N/A N/A N/A N/A +260 +260 +265 +575  
Duke Blue Devils 778 Duke
-850 N/A N/A N/A N/A N/A -375 -375 -385 -850  
  • Opening point spread: Duke -12.5
  • Opening moneyline: Duke -800/TCU +550
  • Opening total: Over/Under 137.5 points scored
  • Time: 5:15 p.m. ET Saturday (CBS)

LATEST UPDATE: Thirty minutes before tipoff, at 4:45 p.m. ET, Duke is a 12.5-point favorite in The SuperBook's NCAA Tournament Second Round odds. The Blue Devils opened -11 on Thursday and initially dipped to -10.5, but they've been climbing ever since.

"Duke is in a lot of moneyline parlays. And there's a lot of moneyline parlay continuing to build today," SuperBook vice president John Murray said. "It's not as one-sided on the spread. There's some support for TCU, but action still favors Duke."

Murray said a TCU cover is good, but an outright upset is much preferred.

OPENING ODDS UPDATE: No. 1 seed Duke (33-2 SU/19-16 ATS) got all it could handle and then some against plucky No. 16 seed Siena. The Blue Devils trailed 43-32 at halftime, but scrambled to pull off a 71-65 victory laying 28.5 points Thursday.

No. 9 seed TCU (23-11 SU/20-14 ATS) squeaked by No. 8 Ohio State 66-64 in the Round of 64's first game Thursday, cashing as a 2.5-point underdog. The Horned Frogs are7-1 SU and ATS in their last eight games.

DraftKings Sportsbook opened Duke -12.5 vs. TCU in March Madness Second Round odds. The first move came within minutes Thursday evening, down to Blue Devils -11.5.

Spread play in the first few hours is solidly tilted toward TCU. As of 9 p.m. ET Thursday, the Horned Frogs are landing 73% of tickets/89% of money.

The total is already up to 139.5 from a 137.5 opener, with 75% of tickets/91% of money on the Over.

Louisville vs. Michigan State Odds

LOU @ MSU Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
Louisville Cardinals 773 Louisville
+3.5 -110 +3 -115 +2.5 -105 +2.5 -115 +3 -105 +2.5 -110 +3.5 -120 +2.5 -105 +3.5 -121 +5.5 -105  
Michigan State Spartans 774 Michigan State
-3.5 -110 -3 -115 -2.5 -125 -2.5 -115 -3 -115 -2.5 -114 -3.5 -105 -2.5 -125 -3.5 -106 -5.5 -115  
Final
Louisville Cardinals 773 Louisville
o150.5 -110 o71 -115 o70.5 -120 o70.5 -115 o71 -115 o70.5 -113 o70.5 -115 o69.5 -115 o70.5 -117 o151.5 -110  
Michigan State Spartans 774 Michigan State
u150.5 -110 u71 -115 u70.5 -110 u70.5 -115 u71 -115 u70.5 -113 u70.5 -110 u69.5 -115 u70.5 -109 u151.5 -110  
Final
Louisville Cardinals 773 Louisville
+154 +145 +145 +135 +162 +152 +145 N/A +160 +215  
Michigan State Spartans 774 Michigan State
-185 -185 -200 -175 -195 -188 +160 N/A -215 -265  
Final
Louisville Cardinals 773 Louisville
+3.5 -110 N/A N/A N/A +2.5 -120 +2.5 -116 +2.5 -115 +2.5 -115 +2.5 -114 +5.5 -105  
Michigan State Spartans 774 Michigan State
-3.5 -110 N/A N/A N/A -2.5 -110 -2.5 -108 -2.5 -115 -2.5 -115 -2.5 -117 -5.5 -115  
Final
Louisville Cardinals 773 Louisville
o150.5 -110 N/A N/A N/A N/A o41.5 -115 N/A N/A N/A o151.5 -110  
Michigan State Spartans 774 Michigan State
u150.5 -110 N/A N/A N/A N/A u41.5 -111 N/A N/A N/A u151.5 -110  
Final
Louisville Cardinals 773 Louisville
+154 N/A N/A N/A N/A N/A +145 +135 +145 +215  
Michigan State Spartans 774 Michigan State
-185 N/A N/A N/A N/A N/A -190 -175 -195 -265  
  • Opening point spread: Michigan State -4.5
  • Opening moneyline: Michigan State -205/Louisville +170
  • Opening total: Over/Under 150.5 points scored
  • Time: 2:45 p.m. ET Saturday (CBS)

LATEST UPDATE: With 45 minutes until tipoff, Michigan State is 5-point chalk in The SuperBook's March Madness odds for the second round. The Spartans opened -4 and quickly advanced to -4.5 Thurday, then went to -5 this morning.

"We took some pretty sharp money on Michigan State -4," SuperBook vice president John Murray said, while noting there's plenty of public support, too. "It's pretty much one-way business on this game. It's one of the more lopsided ticket counts of the tourney so far.

"We're very lopsided to Sparty here. A lot of moneyline parlays on Michigan State, a lot of straight bets and parlays on the spread. We're definitely big Louisville fans."

The total toggled between the 150.5 opener and 151.5 multiple times, then got to 152 this morning. But Murray said there's not much of a decision on it.

OPENING ODDS UPDATE: No. 6 Louisville (24-10 SU/16-18 ATS) blew almost all of a 23-point lead over the final 13 minutes vs. No. 11 South Florida, a very trendy underdog. But the Cardinals held on for an 83-79 victory as 3.5-point favorites Thursday.

No. 3 Michigan State (26-7 SU/18-15 ATS) had no such issues vs. No. 14 North Dakota State. The Spartans built a 45-25 halftime lead and rumbled to a 92-67 win giving 16.5 points.

DraftKings opened Michigan State -4.5 vs. Louisville in NCAA Tournament second-round odds, with no early movement. As of 10 p.m. ET Thursday, 3.5 hours after numbers went up, Michigan State is nabbing 80% of spread bets/91% of spread dollars.

DK's total is pinned to 150.5, with bets almost even and 76% of early money on the Under.

Midwest Region

Kentucky vs. Iowa State Odds

  • Opening point spread: Iowa State -4.5
  • Opening moneyline: Iowa State -200/Kentucky +165
  • Opening total: Over/Under 145.5 points scored
  • Time: 2:45 p.m. ET Sunday (CBS)

LATEST UPDATE: With 45 minutes until tipoff, Iowa State is -4.5 (-115) in BetMGM's NCAA Tournament Second Round odds. That's almost mirrors the opener of Cyclones -4.5 flat, and Iowa State made a couple trips to -5.5 at various juice over the past 44 hours.

Spread tickets and money are in the 2.5/1 range on Iowa State.

"We will need Kentucky and the Under," BetMGM trading manager Christian Cipollini said, noting underdog outright would be quite welcome, with favorites on a huge NCAA Tourney tear. "It seems that the public has certainly caught on to the trend of all the favorites winning.

"So we have seen more action coming in on favorites today. A few 'dogs would be a great outcome."

The total toggled a couple times between 145.5/146.5, also at various juice. It's now 145.5 flat, matching the opener.

No. 2 seed Iowa State (28-7 SU/22-13 ATS) hammered No. 15 Tennessee State 108-74 as a 24.5-point favorite Friday. The Cyclones are on a 5-0 ATS run (4-1 SU).

No. 7 Kentucky (22-13 SU/18-17 ATS) got taken to overtime by No. 10 Santa Clara on Friday. But the Wildcats prevailed 89-84 as 3.5-point favorites.

St. Louis vs. Michigan Odds

SLU @ MICH Odds

  • Full Game
  • 1H
  • Spread
  • Total
  • Moneyline
Final
Saint Louis Billikens 775 Saint Louis
+13.5 -110 +7 -125 +6.5 -115 +6.5 -115 +7 -115 +6.5 -112 +7.5 -105 +4.5 -130 +6.5 -104 +12.5 -118  
Michigan Wolverines 776 Michigan
-13.5 -110 -7 -105 -6.5 -115 -6.5 -115 -7 -105 -6.5 -112 -7.5 -120 -4.5 -110 -6.5 -122 -12.5 -102  
Final
Saint Louis Billikens 775 Saint Louis
o161.5 -110 o77 -115 o76.5 -120 o76.5 -125 o76.5 -115 o76.5 -113 o77.5 -115 o83.5 -125 o76.5 -113 o161.5 -110  
Michigan Wolverines 776 Michigan
u161.5 -110 u77 -115 u76.5 -110 u76.5 -105 u76.5 -115 u76.5 -113 u77.5 -110 u83.5 -115 u76.5 -113 u161.5 -110  
Final
Saint Louis Billikens 775 Saint Louis
+700 +310 +280 +300 +320 +300 +300 N/A +320 +550  
Michigan Wolverines 776 Michigan
-1100 -440 -425 -425 -420 -400 -650 N/A -480 -800  
Final
Saint Louis Billikens 775 Saint Louis
+13.5 -110 N/A N/A N/A +5.5 -120 +6.5 -116 +6.5 -125 +5.5 even +6.5 -125 +12.5 -118  
Michigan Wolverines 776 Michigan
-13.5 -110 N/A N/A N/A -5.5 -110 -6.5 -108 -6.5 -105 -5.5 -130 -6.5 -106 -12.5 -102  
Final
Saint Louis Billikens 775 Saint Louis
o161.5 -110 N/A N/A N/A N/A o45.5 -125 N/A N/A N/A o161.5 -110  
Michigan Wolverines 776 Michigan
u161.5 -110 N/A N/A N/A N/A u45.5 -102 N/A N/A N/A u161.5 -110  
Final
Saint Louis Billikens 775 Saint Louis
+700 N/A N/A N/A N/A N/A +250 +240 +260 +550  
Michigan Wolverines 776 Michigan
-1100 N/A N/A N/A N/A N/A -350 -350 -385 -800  
  • Opening point spread: Michigan -13.5
  • Opening moneyline: Michigan -1100/St. Louis +700
  • Opening total: Over/Under 131.5 points scored
  • Time: 12:10 p.m. ET Saturday (CBS)

LATEST UPDATE: Late Thursday night, DraftKings opened No. 1 seed Michigan -13.5 vs. No. 9 seed St. Louis in March Madness Second Round odds. The Wolverines quickly dipped to -12.5, then Saturday morning went to -11.5 (-115).

With 25 minutes until tip, Michigan is -12.5 (-102) on almost dead-even two-way spread play. The Wolverines are netting 51% of bets, while 52% of money is on St. Louis.

DK's total is painted to 161.5, with 67% of bets/71% of money on the Over.

Michigan (32-3 SU/15-20 ATS) led No. 16 seed Howard by just four at halftime, 50-46 on Thursday night. The Wolverines pulled away in the second half for a 101-80 victory, but were well short of covering as hefty 30.5-point favorites.

In fact, Michigan has yet to cover in March, going 0-6 ATS (5-1 SU).

No. 9 seed St. Louis (29-5 SU/18-15 ATS) stunningly hammered No. 8 seed Georgia 102-77 Thursday. The Billikens were 1.5-point underdogs, yet at one point late in the second half led by 40 at 100-60.

The surprising rout ended an 0-4 ATS skid for St. Louis.

NCAA Tournament Kalshi Odds

Prediction markets such as Kalshi are also involved with college basketball conference tournaments. Check out the Kalshi promo code before trading on NCAA Tournament futures odds:

  • Michigan +376
  • Arizona +400
  • Duke +456
  • Florida +900
  • Houston +1329
  • Illinois +1900
  • Purdue +1900
  • Iowa State +2400
  • UConn +3233
  • Michigan State +3233
  • Arkansas +3233
  • St. John's +3233

For more, check out VegasInsider's 2026 NCAA Tournament futures odds.

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Patrick Everson

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson
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