Last Updated Apr 16 2025, 3:45 PM

2025 NCAA Tournament South Region Odds

Kevin Rogers Sports Betting Expert

15 minute read

NCAAB Futures Odds

In the 2025 NCAA Tournament’s South Region, Auburn and Michigan State battled for a spot in the Final Four, with Auburn coming out on top as the regional champion. After defeating Michigan State in the regional final, Auburn advanced to the Final Four, where they fell to Florida. On the other side of the bracket, Houston knocked off Duke to reach the title game. Florida then edged out Houston in the championship to secure the 2025 national title.

Looking for more basketball action? Check out our NBA odds.

Michael O'Connell and the North Carolina State Wolfpack have won three times as underdogs in the South Region. (Getty)

South Region Betting Results

Straight Up (SU)
Against the Spread (ATS)
Over-Under (OU)

Favorites-Underdogs (SU): 9-6
Favorites-Underdogs (ATS): 6-9
Over-Under: 8-7

NCAA Tournament South Region Schedule

First & Second Round Matchups

Thursday, Mar. 21
No. 14 Oakland 80 (+13.5) No. 3 Kentucky 75 - Under 159.5
No. 11 N.C. State 80 (+4.5) No. 6 Texas Tech 67 - Over 146.5

Friday, Mar. 22
No. 2 Marquette 87 (-15) No. 15 Western Kentucky 69 - Under 157
No. 10 Colorado 102 (-1.5) No. 7 Florida 100 - Over 157.5
No. 9 Texas A&M 98 (-1) No. 8 Nebraska 83 - Over 149
No. 4 Duke 64 (-12.5) No. 13 Vermont 47 - Under 133
No. 1 Houston 86 (-24.5) No. 16 Longwood 46 - Over 129.5
No. 12 James Madison 72 (+4.5) No. 5 Wisconsin 61 - Under 143.5

Saturday, Mar. 23
No. 11 N.C. State 79 (-6.5) Oakland 73 - Over 146.5

Sunday, Mar. 24
No. 2 Marquette 81 (-4.5) Colorado 77 - Over 151.5
No. 4 Duke 93 (-6.5) James Madison 55 - Over 147.5
No. 1 Houston 100 (-8.5) Texas A&M 95 - Over 134.5

Sweet Sixteen & Elite Eight Matchups

Friday, Mar. 29
No. 11 N.C. State 67 (+7.5) No. 2 Marquette 58 - Under 151.5
No. 4 Duke (+4.5) 54 No. 1 Houston 51 - Under 133.5

Sunday, Mar. 31
No. 11 N.C. State (+7.5) 76 No. 4 Duke 64 - Under 141.5

2025 NCAA Tournament South Region Opening Odds

Opening Odds to Win the NCAA Tournament South Region

(Seed) Team	Odds
1) Houston Cougars	+120
2) Marquette Golden Eagles	+600
3) Kentucky Wildcats	+600
4) Duke Blue Devils	+750
5) Wisconsin Badgers	+1500
6) Texas Tech Red Raiders	+1600
7) Florida Gators	+1100
8) Nebraska Cornhuskers	+2500
9) Texas A&M Aggies	+3300
10) Colorado Buffaloes	+3300
10) Boise State Broncos	+4000
11) North Carolina State Wolfpack	+3000
12) James Madison Dukes	+4000
13) Vermont Catamounts	+12500
14) Oakland Golden Grizzlies	+12500
15) Western Kentucky Hilltoppers	+15000
16) Longwood Lancers	+15000

Odds Provided by bet365

The Houston Cougars are listed as +120 favorites to win the South Region of the NCAA Tournament. (Getty)

2025 NCAA Tournament South Region Teams

Listed in Seed Order (Conference - Bid)

1) Houston Cougars
(Big 12, At-Large)

Futures: +500
Region: +120
SU: 30-4
ATS: 16-16-2
O/U: 14-20
PPG: 74.2
OPPG: 56.9

2) Marquette Golden Eagles
(Big East, At-Large)

Futures: +2300
Region: +600
SU: 25-9
ATS: 20-13-1
O/U: 14-20
PPG: 79.2
OPPG: 69.8

3) Kentucky Wildcats
(SEC, At-Large)

Futures: +3000
Region: +600
SU: 23-9
ATS: 18-14
O/U: 23-9
PPG: 89.5
OPPG: 79.1

4) Duke Blue Devils
(ACC, At-Large)

Futures: +3900
Region: +750
SU: 24-8
ATS: 18-14
O/U: 13-19
PPG: 80.2
OPPG: 67.2

5) Wisconsin Badgers
(Big Ten, At-Large)

Futures: +5500
Region: +1500
SU: 22-13
ATS: 15-18-2
O/U: 23-11
PPG: 74.4
OPPG: 69.8

6) Texas Tech Red Raiders
(Big 12, At-Large)

Futures: +11000
Region: +1600
SU: 23-10
ATS: 15-17-1
O/U: 19-14
PPG: 75.9
OPPG: 69.0

7) Florida Gators
(SEC, At-Large)

Futures: +6500
Region: +1100
SU: 24-11
ATS: 16-18-1
O/U: 22-12-1
PPG: 84.9
OPPG: 77.6

8) Nebraska Cornhuskers
(Big Ten, At-Large)

Futures: +13000
Region: +2500
SU: 23-10
ATS: 21-12
O/U: 22-11
PPG: 76.8
OPPG: 69.3

9) Texas A&M Aggies
(SEC, At-Large)

Futures: +17000
Region: +3300
SU: 20-14
ATS: 16-18
O/U: 21-13
PPG: 73.4
OPPG: 69.5

10) Colorado Buffaloes
(Pac-12, At-Large)

Futures: +15000
Region: +3300
SU: 24-10
ATS: 17-17
O/U: 20-14
PPG: 80.6
OPPG: 72.1

10) Boise State Broncos
(Mountain West, At-Large)

Futures: +22000
Region: +4000
SU: 22-10
ATS: 15-13-1
O/U: 16-14
PPG: 76.1
OPPG: 67.3

11) North Carolina State Wolfpack
(ACC, Automatic)

Futures: +17000
Region: +3000
SU: 22-14
ATS: 17-18-1
O/U: 21-14-1
PPG: 75.5
OPPG: 72.8

12) James Madison Dukes
(Sun Belt, Automatic)

Futures: +25000
Region: +4000
SU: 31-3
ATS: 19-14
O/U: 17-16
PPG: 84.6
OPPG: 69.3

13) Vermont Catamounts
(America East, Automatic)

Futures: +35000
Region: +12500
SU: 28-6
ATS: 14-18
O/U: 9-23
PPG: 72.6
OPPG: 62.9

14) Oakland Golden Grizzlies
(Horizon, Automatic)

Futures: +35000
Region: +12500
SU: 23-11
ATS: 21-13
O/U: 20-13-1
PPG: 76.3
OPPG: 73.1

15) Western Kentucky Hilltoppers
(Conference USA, Automatic)

Futures: +40000
Region: +15000
SU: 22-11
ATS: 19-11
O/U: 15-15
PPG: 80.2
OPPG: 75.0

16) Longwood Lancers
(Big South, Automatic)

Futures: +50000
Region: +15000
SU: 21-13
ATS: 16-15
O/U: 17-14
PPG: 75.3
OPPG: 68.3

Key
Futures: Odds to Win NCAA Tournament
Region: Odds to Win East Region
SU: Straight Up
ATS: Against the Spread
O/U: Over-Under
PPG: Points Per Game
OPPG: Opponents Per Game

MARCH MADNESS BETTING RESOURCES

BETTING ODDS RESOURCES

Kevin Rogers

Kevin has been handicapping professionally since 2007 at VegasInsider before shifting to ScoresAndOdds. He focuses on MLB, NFL, college football, NBA, college basketball, and NHL and mainly uses trends, systems, and situations as his top handicapping angles. More from Kevin Rogers