Oregon vs South Carolina Prediction, Picks, Odds | NCAA Tournament First Round Bets

The First Round of NCAA Men's Basketball Tournament kicks off on Thursday, March 21 -- and the seventh matchup on the slate set to tip off is Oregon vs South Carolina, which is scheduled for 4:00 p.m. ET on TNT.
The Ducks are short 1-point underdogs on the spread in Thursday's contest; with the game total stationed near over/under 143 at most sportsbooks.
Here's everything you need to know about Oregon vs South Carolina — our expert prediction and betting picks for this First Round NCAA Tournament matchup.
Oregon vs South Carolina Odds
OREGON @ SC Odds
Time | Open | Bet365 | BetMGM | DraftKings | ESPNBet | FanDuel | RiversCasino | HardRock | Consensus | |
---|---|---|---|---|---|---|---|---|---|---|
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
![]() | +1.5 -115 | -2.5 -110 | -2.5 -110 | -2.5 -108 | -2.5 -110 | -2.5 -110 | -2.5 -113 | -2.5 -115 | -2.5 -110 | |
![]() | -1.5 -105 | +2.5 -110 | +2.5 -110 | +2.5 -112 | +2.5 -110 | +2.5 -110 | +2.5 -108 | +2.5 -115 | +2.5 -110 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
![]() | o133.5 -110 | o136 -110 | o133.5 -115 | o135.5 -112 | o135.5 -110 | o135.5 -115 | o135.5 -112 | o135.5 -115 | o135.5 -115 | |
![]() | u133.5 -110 | u136 -110 | u133.5 -105 | u135.5 -108 | u135.5 -110 | u135.5 -105 | u135.5 -108 | u135.5 -115 | u135.5 -105 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
![]() | -108 | -150 | -145 | -148 | -140 | -144 | -143 | -150 | -144 | |
![]() | -111 | +125 | +120 | +124 | +120 | +120 | +115 | +115 | +120 | |
Time | Open | Bet365 | BetMGM | DraftKings | ESPNBet | FanDuel | RiversCasino | HardRock | Consensus | |
---|---|---|---|---|---|---|---|---|---|---|
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
![]() | +1.5 -115 | -1 -115 | -0.5 -115 | -1 -120 | -1.5 -110 | N/A | -1 -112 | -1.5 -110 | -2.5 -110 | |
![]() | -1.5 -105 | +1 -105 | +0.5 -115 | +1 -110 | +1.5 -120 | N/A | +1 -114 | +1.5 -120 | +2.5 -110 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
![]() | o133.5 -110 | o62.5 -105 | N/A | o62.5 -115 | o62.5 -125 | o62.5 -104 | o63 -109 | o62.5 -125 | o135.5 -115 | |
![]() | u133.5 -110 | u62.5 -115 | N/A | u62.5 -115 | u62.5 -105 | u62.5 -122 | u63 -117 | u62.5 -105 | u135.5 -105 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
![]() | -108 | N/A | -115 | -145 | -145 | N/A | -130 | N/A | -144 | |
![]() | -111 | N/A | -110 | +114 | +115 | N/A | +108 | N/A | +120 | |
Time | Open | Bet365 | BetMGM | DraftKings | ESPNBet | FanDuel | RiversCasino | HardRock | Consensus | |
---|---|---|---|---|---|---|---|---|---|---|
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
![]() | +1.5 -115 | +0.5 -115 | N/A | N/A | N/A | -0.5 -120 | -1 -109 | N/A | -2.5 -110 | |
![]() | -1.5 -105 | -0.5 -105 | N/A | N/A | N/A | +0.5 -104 | +1 -117 | N/A | +2.5 -110 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
![]() | o133.5 -110 | o73 -110 | N/A | N/A | N/A | o73.5 -116 | N/A | N/A | o135.5 -115 | |
![]() | u133.5 -110 | u73 -110 | N/A | N/A | N/A | u73.5 -108 | N/A | N/A | u135.5 -105 | |
Final | Open | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | | |
![]() | -108 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | -144 | |
![]() | -111 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | +120 | |
Oregon vs South Carolina Prediction
Oregon wasn't exactly a lock to get into the NCAA Tournament as an at-large team, but took care of business by beating Colorado in the Pac-12 title game to grab the automatic bid.
The Ducks face a much-improved South Carolina squad that went from 11-21 last season to 26-7 this season. The Gamecocks surprised Tennessee, Kentucky, and Florida in SEC play, while slowing the tempo down to a crawl in each game.
Oregon started Pac-12 play at 5-0 before a 7-8 finish over the final 15 games. The Ducks went 1-5 against the Top-3 teams in the conference (Arizona, Washington State, and Colorado), but posted an 11-3 mark against the rest of the league, who all owned Pac-12 records of .500 or worse.
South Carolina should be able to bounce back here after getting routed by Auburn at the SEC tournament as the Gamecocks were 5-1 ATS this season as a favorite of 5.5 points or less.
Pick: South Carolina -1 (-110)
Oregon vs South Carolina Game Time & TV Channel
Date: Thursday, March 21
Matchup: Pac-12 vs SEC
Venue: PPG Paints Arena
Location: Pittsburgh, PA
Time-TV: TNT, 4:00 p.m. ET
Oregon vs South Carolina Betting Stats
6) South Carolina Gamecocks
(SEC, At-Large)
- Futures: +12000
- Region: +2800
- SU: 26-7
- ATS: 23-10
- O/U: 16-17
- PPG: 72.3
- OPPG: 66.4
11) Oregon Ducks
(Pac-12, Automatic)
- Futures: +22000
- Region: +6000
- SU: 23-11
- ATS: 16-18
- O/U: 20-4
- PPG: 75.8
- OPPG: 72.6
March Madness Betting Resources
- NCAA Tourney Picks
- NCAAB Matchups
- NCAAB Scores
- NCAAB Teams
- NCAAB Free Picks
- NCAAB Premium Picks
- NCAAB Consensus Picks
- NCAAB Parlay Picks
- March Madness History
March Madness First Round Odds
The NCAA Men's Tournament First Round will take place on Thursday March 21, 2024 and Friday March 22, 2024.
Check out the Teams, Odds, Betting Stats and much more on each of the four regions below:
College Basketball News
- COLLEGE-BASKETBALL APR 6, 2025
Free NCAAB Picks & Predictions By Vegas Insider
- COLLEGE-BASKETBALL APR 6, 2025
2025 NCAA Men’s Basketball National Championship Odds
- COLLEGE-BASKETBALL MAR 12, 2025
2025 WCC Tournament Odds: Gonzaga Favored vs. St. Mary’s In Final
- COLLEGE-BASKETBALL MAR 19, 2025
NCAAB: Xavier vs. Texas NCAA Tournament First Four Pick & Prediction
- COLLEGE-BASKETBALL APR 6, 2025
Final Four Odds: 2025 March Madness Lines, Spreads, Betting Trends
- COLLEGE-BASKETBALL APR 7, 2025
Florida vs. Houston Odds, Lines, Betting Trends & Predictions For NCAA Championship Game
Featured News
- FEATURED APR 16, 2025
NBA: Dallas Mavericks at Sacramento Kings Pick & Prediction
- FEATURED APR 17, 2025
NBA Playoff Odds: First Round Lines, Spreads, Betting Trends
- FEATURED MAR 26, 2025
2025 World Series Odds: MLB Playoffs, World Series Futures & Betting Trends
- FEATURED MAR 10, 2025
Longest Losing Streaks in NBA History
- FEATURED APR 6, 2025
Free NCAAB Picks & Predictions By Vegas Insider
- FEATURED FEB 13, 2025
Super Bowl 60 Futures: Eagles Atop Odds Board as Favorites to Repeat