2025 Women’s March Madness Odds: Title Favorites, Lines, Spreads, and Betting Trends

Patrick Everson Sports Betting Expert

2 minute read

Women's March Madness odds are onto the Final Four this week. Three No. 1 seeds are still in the mix. And of course, there's UConn.

This weekend in Tampa, Fla., it'll be No. 1 Texas vs. No. 1 South Carolina, and No. 2 UConn vs. No. 1 UCLA.

Here's everything you need to know about Women's March Madness odds for the Final Four matchups: lines, spreads and betting trends on both games, and insights on championship futures. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

Women's March Madness Odds

Final Four

Texas vs. South Carolina Odds

• Opening point spread: South Carolina -4.5
• Opening moneyline: South Carolina -198/Texas +164
• Opening total: Over/Under 127.5 points scored
• Time: 7 p.m. ET Friday (ESPN)

UPDATE 7:30 P.M. ET TUESDAY: South Carolina remains -4.5 (-115) in DraftKings Sportsbook's Women's March Madness odds for the Final Four. The Gamecocks opened -4.5 flat, and the juice adjusted shortly thereafter on Monday night.

Earl point-spread play is solidly on South Carolina, with ticket count 2/1 and money 4/1.

DK opened the total at 127.5 and today dipped to 126.5 (Under -115). The Under is netting 60% of early tickets/93% of early cash.

UPDATE 11 P.M. ET MONDAY: No. 1 seed and defending national champion South Carolina (34-3 SU) survived Sweet 16 and Elite 8 challenges to get back to the Final Four.

On Sunday night, the Gamecocks were 9.5-point favorites and held off No. 2 seed Duke 54-50 in the Region 2 final. That came two days after edging No. 4 seed Maryland 71-67.

No. 1 seed Texas topped No. 2 seed TCU 58-47 tonight in the Region 3 final. The Longhorns (35-3 SU) covered as 6.5-point favorites, and in their 4-0 March Madness run so far, they've won each game by at least 9 points.

DraftKings Sportsbook opened South Carolina -4.5 flat tonight, then made the modest adjustment to -4.5 (-115). The total is stable at 127.5. Check back for updates on Women's March Madness odds and action.

UConn vs. UCLA Odds

• Opening point spread: UConn -10.5
• Opening moneyline: UConn -650/UCLA +470
• Opening total: Over/Under 135.5 points scored
• Time: 9 p.m. ET Friday (ESPN)

UPDATE 7:30 P.M. ET TUESDAY: So far, all the movement in this matchup came in the minutes after UConn opened -10.5 at DraftKings on Sunday night. The Huskies made a stop at -9.5 and -8.5, then adjusted to -8.5 (-105), where they remain tonight.

Underdog UCLA is seeing 54% of early spread bets/64% of early spread dollars.

The total hasn't budged off 135.5 at DraftKings, where 65% of bets are on the Over and 63% of cash is on the Under.

UPDATE 11:45 P.M. ET MONDAY: UConn (34-3 SU) is the lone No. 2 seed to reach the Final Four. A contributing factor: No. 1 seed USC didn't have Player of the Year candidate JuJu Watkins, who suffered a torn ACL in the second round.

In tonight's Region 4 final, UConn was a 14.5-point favorite and knocked out USC 76-64. The Huskies are making their 24th Final Four appearance, but they haven't won it all since 2016, when they completed a four-peat.

UConn is now the favorite to win the championship.

No. 1 seed UCLA (34-2 SU) took the Region 1 title. In Sunday's regional final, the Bruins were laying 4.5 points and beat No. 3 seed LSU 72-65. UCLA's only losses this season came to crosstown rival USC, against a healthy Watkins.

Moments ago, UConn opened as hefty 10.5-point chalk vs. UCLA in DraftKings' Women's March Madness odds. That line quickly got hit and moved toward underdog UCLA, with the Huskies now -8.5 (-105). The total is stable at 135.5.

Check back this week for updates on action and odds moves in the Women's Final Four.

Odds To Win 2025 Women's March Madness

DraftKings' odds to win the Women's NCAA Tournament, for each of the Final Four teams:

• UConn -150
• South Carolina +250
• Texas +700
• UCLA +750

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson