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College Football

College Football Odds Week 1: Ohio State vs Indiana Lines, Spreads, Betting Trends

Patrick Everson
Patrick Everson Sports Betting Expert
1 minute read
Matchup Spread Total Moneyline
Indiana vs
Ohio State 		+29.5 (-105)
-29.5 (-115) 		o59.5 (-105)
u59.5 (-115) 		+2200
-10000

College football odds for Week 1 are on the board and receiving plenty of attention as we tackle all the major storylines of the weekend. The Ohio State Buckeyes and Indiana Hoosiers meet at Memorial Stadium in Bloomington on Saturday, September 2 at 3:30 p.m. ET on CBS.

Here's everything you need to know about the college football odds for the Week 1 game between Ohio State and Indiana: the opening lines, spreads, betting trends and more. Check back regularly for updates.

No. 3 Ohio State vs Indiana Odds

Ohio State coach Ryan Day, left, and possible starting QB Kyle McCord hope Week 1 is the start of a return trip to the College Football Playoff. (Getty)
  • Opening point spread: Ohio State -28.5
  • Opening moneyline: Ohio State -10000/Indiana +2000
  • Opening total: Over/Under 59.5 points scored
  • Time: 3:30 p.m. ET (CBS)

UPDATE 4 P.M. ET MONDAY: Ohio State is coming off a College Football Playoff appearance, but no longer has C.J. Stroud under center. The star QB was drafted No. 2 overall by the Houston Texans.

In the CFP semis, Ohio State let multiple double-digit leads slip away in a 42-41 loss to Georgia as a 4.5-point point 'dog. The Buckeyes finished the year 11-2 SU/6-6-1 ATS.

Indiana won its first three games in 2022, then saw the season fall apart with a seven-game losing streak. The Hoosiers finished 4-7 SU and ATS.

TwinSpires has only had this game up since Aug. 22, and the Buckeyes are up a point to -29.5. Indiana is taking 55% of tickets and Ohio State 59% of money.

"Good two-way action so far. I'm not surprised to see more tickets on Indiana. Getting four TDs at home is enticing," Lucas said.

The total is up a point to 60.5, with 62% of tickets/56% of money on the Over.

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Patrick Everson

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson
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