College Football Odds Week 10: Notre Dame vs Clemson Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

2 minute read

Clemson has struggled of late as the Tigers will have another tough test against Notre Dame in Week 10 of college football. Betting odds see the Fighting Irish as 3-point road favorites against the Tigers. Coverage begins from Clemson on Saturday, November 4 at 12:00 p.m. ET on ABC.

Here's everything you need to know about the college football odds for Week 10 Notre Dame vs Clemson: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

No. 12 Notre Dame vs Clemson Odds

• Opening point spread: Notre Dame -2.5
• Opening moneyline: Notre Dame -160/Clemson +135
• Opening total: Over/Under 46 points scored
• Time: Noon ET Saturday (ABC)

UPDATE 11 A.M. ET SATURDAY: As was the case Friday at BetMGM (see below updated), Notre Dame-Clemson is the most-bet game in the college football Week 10 odds market. And Notre Dame continues to draw the most spread tickets, though it slipped to No. 2 in spread dollars, behind Alabama.

In the past hour, Notre Dame nudged from -3 (-115) to -3.5. Ticket count and money are both approaching 4/1 on the Fighting Irish. And bettors are on Notre Dame moneyline, as well, at 59% of tickets/79% of money.

"The Tigers of LSU and Clemson are two other underdogs we’re cheering for, as the money keeps pouring in on Alabama and Notre Dame," BetMGM's Seamus Magee said.

The total is down a point since Friday afternoon, going to 44/43.5 this morning. Current splits aren't available.

UPDATE 1 P.M. ET FRIDAY: Perhaps surprisingly, with LSU-Bama on the schedule, Notre Dame-Clemson is the most-bet game by ticket count in BetMGM's college football odds Week 10 market.

The Fighting Irish have spent almost all week as 3-point faves at BetMGM, save for a few hours Monday at -2.5. Notre Dame is currently -3 (-115), with tickets and money running 4/1 on the Irish.

Notre Dame is taking more spread tickets and money than any team on the Week 10 schedule.

The total opened at 46 and by Tuesday dropped to 44.5, where it remains. Ticket count is dead even, but money is 5/1 on the Under.

UPDATE 3 P.M. ET MONDAY: Notre Dame (7-2 SU and ATS) followed its loss to Louisville with two blowout victories. In Week 9 vs. Pittsburgh, the Fighting Irish rumbled to a 58-7 win giving 21 points at home.

Clemson, for years a CFP stalwart, is having its worst season in recent memory, sitting at 4-4 SU/2-6 ATS. In Week 9, the Tigers tumbled to North Carolina State 24-17 as 10-point road favorites.

Notre Dame moved from -2.5 to -3 shortly after opening Sunday at Caesars Sports. This morning, the Irish returned to -2.5. The total is down a point to 45.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 10 Report containing spreads, lines, and trends for every Top 25 matchup.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson