College Football Odds Week 10: Washington vs USC Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

2 minute read

Week 10 of the college football season continues with a Top 25 showdown in the Pac-12 between Washington and USC. The betting odds favor the Huskies by a field goal as they try to stay undefeated in a road matchup against the 24th-ranked Trojans. Coverage begins from Los Angeles Memorial Coliseum on Saturday, November 4 at 7:30 p.m. ET on ABC.

Here's everything you need to know about the college football odds for Week 10 Washington vs. USC: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

No. 5 Washington vs No. 24 USC Odds

• Opening point spread: Washington -4.5
• Opening moneyline: Washington -205/USC +163
• Opening total: Over/Under 76.5 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

UPDATE 7 P.M. ET SATURDAY: Washington moved from -3.5 to -4, then quickly fell back to -3.5 Monday. On Wednesday, the Huskies dipped to -3, and the line has been at -3 (-105) since Thursday.

"It seems the sharps are on USC and the public is on Washington," BetMGM senior trader Cameron Drucker said. "Not a huge need either way, as of now."

UPDATE 6:30 P.M. ET THURSDAY: This line has spent most of the week toggling between Washington -3.5 and -3 at The SuperBook, save for a few hours Monday morning at -4. It's been stable at Huskies -3 since Wednesday morning.

"Ticket count is dead even, but there's definitely more money on USC so far," Degnon said. "We took sharp action on USC +4 and +3.5."

UPDATE 3 P.M. ET MONDAY: In two games since a riveting win over Oregon, Washington hasn't looked great, but remains undefeated. The Huskies (8-0 SU/3-4-1 ATS) topped Stanford 44-33, falling well short of covering the 27.5-point spread.

USC (7-2 SU/2-7 ATS) has arguably provided five straight disappointing efforts, with the latest nearly leading to a third straight loss. The Trojans closed as 10-point favorites at California and trailed 43-29 early in the fourth quarter. But Southern Cal rallied for a wild 50-49 victory.

The Huskies are already down a point to -3.5 in TwinSpires' college football odds Week 10 market. Ticket count is almost 2/1 and money 2.5/1 on the Trojans.

"It's a mix of sharp and public play on USC +4.5. USC is another trendy 'dog, as Washington hasn't looked all that great the last two weeks," Lucas said.

The lofty total crept down from 76.5 to 76, with 66% of early tickets/54% of early dollars on the Over.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 10 Report containing spreads, lines, and trends for every Top 25 matchup.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson