College Football Odds Week 5: Notre Dame vs Duke Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
Duke vs
Notre Dame
+4.5 (-105)
-4.5 (-115)
o52.5 (-115)
u52.5 (-105)
+164
-200

The Week 5 college football betting odds see the Notre Dame Fighting Irish favored by less than a touchdown over the Duke Blue Devils in this Top 25 showdown. Coverage begins from Wallace Wade Stadium in Durham, North Carolina on Saturday, September 30 at 7:30 p.m. ET on ABC.

Here's everything you need to know about the college football odds for Week 5 Notre Dame vs Duke: the opening lines, spreads, betting trends and more. Check back regularly for updates.

No. 11 Notre Dame vs No. 17 Duke Odds

Notre Dame looks to rebound in a Week 5 matchup at Duke. (Getty)
  • Opening point spread: Notre Dame -5.5
  • Opening moneyline: Notre Dame -215/Duke +170
  • Opening total: Over/Under 51 points scored
  • Time: 7:30 p.m. ET Saturday (ABC)

UPDATE 6:45 P.M. ET SATURDAY: With 45 minutes until kickoff, Notre Dame remains -5.5, with the number sticking there all week at BetMGM Nevada. Ticket count is 3/1 and money 6/1 on Notre Dame in BetMGM's Las Vegas market.

"It's basically all public action on Notre Dame spread," BetMGM Nevada's Scott Shelton said. "On the moneyline, it's 2/1 tickets Duke, but money is really close."

The total climbed from 51.5 to 54.5 by Thursday, but quickly receded to 52.5. It's now 52.5 (Over -115).

"Tickets are dead even, but it's 3/1 money on the Over," Shelton said.

UPDATE 3 P.M. ET THURSDAY: Notre Dame moved from -5 to -5.5 Sunday night at PointsBet and hasn't budged since. Pont-spread ticket count is 3/1 and practically all the early spread cash is on the Fighting Irish.

The total initially backed up, going from the 52 opener to 50.5 by Monday afternoon. It then climbed as high as 54.5, reaching that mark this morning before receding to 53. The Over is seeing 53% of tickets, while 64% of money is on the Under.

UPDATE 3 P.M. ET MONDAY: With a little better clock management – and perhaps timeout usage in extremely important situations – Notre Dame would likely still be unbeaten. But alas, the Fighting Irish (4-1 SU and ATS) gave up a final-seconds TD to Ohio State, losing 17-14 as 3.5-point home 'dogs.

Duke (4-0 SU/3-1 ATS) continues to build off its Week 1 upset of Clemson. In Week 4, the Blue Devils drilled UConn 41-7 laying 22 points on the road.

Notre Dame hasn't moved off -5.5 in TwinSpires' college football odds Week 5 market. The Irish are getting 52% of early tickets, and 51% of early money is on the Blue Devils.

"Action is right down the middle, by a few dollars," Lucas said.

The total dipped a point to 50, with 60% of tickets/63% of money on the Under early on.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 5 Report containing spreads, lines, and trends for every Top 25 matchup.