College Football Odds Week 7: Louisville vs Pittsburgh Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
Pittsburgh vs
Louisville
+7.5 (-120)
-7.5 (-102)
o45.5 (-105)
u45.5 (-115)
+240
-300

Louisville has jumped out to a 6-0 start as the Cardinals try to stay undefeated with a trip to Pittsburgh in Week 7 of college football. Betting odds see the Cardinals listed as 7.5-point road favorites against the Panthers. Coverage begins from Acrisure Stadium on Saturday, October 14 at 6:30 p.m. ET on the CW.

Here's everything you need to know about the college football odds for Week 7 Louisville vs Pittsburgh: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

No. 14 Louisville vs Pittsburgh Odds

Louisville looks to avoid a letdown spot at Pittsburgh this week. (Getty)
  • Opening point spread: Louisville -10.5
  • Opening moneyline: Louisville -335/Pittsburgh +260
  • Opening total: Over/Under 47.5 points scored
  • Time: 6:30 p.m. ET Saturday (CW Network)

UPDATE 3 P.M. ET THURSDAY: This line crashed in a hurry at multiple sportsbooks. PointsBet opened the Cardinals -10 (-105) Sunday afternoon and within three hours was down to -7.5 (-115).

Louisville rebounded to -8 Sunday night, then returned to -7.5 Tuesday morning. The Cardinals are drawing 61% of early spread bets, while 79% of early spread money is on the Panthers. PointsBet noted it was definitely early sharp money on Pitt that drove the number down in the college football odds Week 7 market.

The total fell from 47.5 to 46 by Monday afternoon, then to 45 (Under -120 late Wednesday night. It bottomed out today at 44.5 before returning to 45 (Under -120). Ticket count is 2.5/1 on the Over, but money is almost 8/1 on the Under.

UPDATE MIDNIGHT ET MONDAY: Louisville (6-0 SU/3-2-1 ATS) is making some noise in the ACC. The Cardinals closed as 6.5-point home 'dogs against Notre Dame and pulled away in the fourth quarter for a 33-20 victory.

Pitt (1-4 SU and ATS) is on a four-game SU and ATS slide. The Panthers, who had a bye last week, fell to Virginia Tech 38-21 as 3-point road faves in Week 5.

Interestingly, this line quickly dropped from Louisville -10.5 to -8.5 Sunday afternoon at Caesars. And it fell another point today to Louisville -7.5. The total is down to 46 from the 47.5 opener.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 7 Report containing spreads, lines, and trends for every Top 25 matchup.