2025 College Football Odds Week 9: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

6 minute read

The College Football Odds Week 9 market is seemingly like every week this time of year. SEC clashes are the biggest ones on the board.

Texas A&M vs. LSU. Ole Miss vs. Oklahoma. Missouri vs. Vanderbilt. But there are other interesting matchups in college football Week 9 odds, including recent upstart UCLA vs. undefeated Indiana.

Here’s everything you need to know about college football odds Week 9: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 9 college football odds and action.

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(Feature image: Kim Klement Neitzel/Imagn Images)

2025 College Football Odds for Week 9

UCLA vs. Indiana Odds

• Opening point spread: Indiana -21
• Opening moneyline: Indiana TBA/UCLA TBA
• Opening total: Over/Under 54.5 points scored
• Time: Noon ET Saturday (FOX)

EARLY WEEK UPDATE: Borgata Sports opened Indiana -24.5 in college football Week 9 odds and was up to -25.5 by Tuesday.

"Indiana has now moved up to No. 2 in the AP poll after its win against Michigan State," Borgata sportsbook director Tom Gable said. "UCLA is on a three-game win streak under interim head coach Tim Skipper. It’s a big number to lay, and we haven’t seen a lot of action on this game yet."

OPENING ODDS UPDATE: Indiana (7-0 SU/4-3 ATS) had no letdown after its huge Week 7 win at Oregon. In Week 8, the Hoosiers put up 28 points in the middle two quarters (14 in each) and rolled over Michigan State 38-13, just short of cashing as 26.5-point home chalk.

UCLA (3-4 SU and ATS) wouldn't normal merit mention in this space, with a sub-.500 record. But in Week 6, the Bruins played world beater and shocked Penn State 42-37 as a massive 24-point home underdog, beginning the demise of James Franklin and the Nittany Lions.

Now, UCLA is on a three-game win streak. In Week 8, the Bruins edged Maryland 20-17 on a final-seconds field goal, though they failed to cash as 4-point home favorites.

Still, No. 2 Indiana opened as a hefty 21-point home favorite in Circa Sports' college football Week 9 odds. Circa is widely respected for its opening numbers, which tend to draw sharp action in a hurry.

That was the case here, as that line quickly shot to Hoosiers -24.5 by 1:40 p.m. ET Sunday.

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Ole Miss vs. Oklahoma Odds

• Opening point spread: Oklahoma -4
• Opening moneyline: Oklahoma TBA/Ole Miss TBA
• Opening total: Over/Under 53.5 points scored
• Time: Noon ET Saturday (ABC)

EARLY WEEK UPDATE: Oklahoma opened as 4.5-point home chalk in Borgata Sports' college football odds Week 9 market. On Tuesday, the Sooners are up to -5.5.

"Ole Miss just suffered its first loss and now has to travel to Oklahoma, which got back on track with a blowout win against South Carolina," Borgata sportsbook director Tom Gable said. "The Sooners' offensive and defensive lines dominated in that game.

"But it will be a much stiffer test here against Ole Miss."

The total is a notable early mover, shooting from 51.5 to 54.5.

OPENING ODDS UPDATE: No. 8 Ole Miss (6-1 SU/4-3 ATS) was primed to remain unbeaten, holding a 35-26 lead over Georgia late in the third quarter. But the Rebels gave up the final 17 points of the game and lost 43-35 as 7.5-point road underdogs.

No. 13 Oklahoma (6-1 SU/4-3 ATS) bounced back just fine from its Week 7 loss vs. Texas. The Sooners dumped South Carolina 26-7 laying 4.5 points on the road.

Circa Sports opened Ole Miss-Oklahoma at Sooners -4 and quickly went to -5. Thirty minutes later, around 2:15 p.m. ET Sunday, the line settled at -4.5. The total was also on the move early, falling from 53.5 to 51.

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South Florida vs. Memphis Odds

• Opening point spread: South Florida -3
• Opening moneyline: South Florida TBA/Memphis TBA
• Opening total: Over/Under 65.5 points scored
• Time: Noon ET Saturday (ESPN2)

EARLY WEEK UPDATE: As of Tuesday morning, South Florida is already out to -5.5 in Borgata Sports' Week 9 college football odds. The Bulls opened Sunday as 3.5-point road favorites.

"South Florida has an offense that has been putting up a lot of points, with dual-threat quarterback Byrum Brown leading the way," Borgata sportsbook director Tom Gable said. "Memphis has at times struggled to contain mobile quarterbacks and is coming off a loss to UAB.

"It’s been all recreational money thus far on the home dog, with respected money coming in on the favorite."

The total is down to 63.5 from a 65.5 opener.

OPENING ODDS UPDATE: No. 18 South Florida (6-1 SU and ATS) is the highest-ranked Group of 6 team, meaning its on track for a CFP bid – if it wins the American Athletic Conference. In Week 8, the Bulls hammered Florida Atlantic 48-13 as 20.5-point home favorites

Memphis (6-1 SU) will still have something to say about the AAC title, though it stubbed its toe big-time in Week 8. The Tigers were 23.5-point favorites at UAB and shockingly fell outright 31-24, to a team that fired coach Trent Dilfer last Sunday.

That loss took some luster off what was supposed to be a Week 9 showdown between the AAC's two best teams. South Florida opened as 3-point road chalk in Circa Sports' college football odds Week 9 market.

The first move was to USF -2.5, but the line quickly rebounded to -3, then went to -3.5 by 2:25 p.m. ET Sunday.

Missouri vs. Vanderbilt Odds

• Opening point spread: Vanderbilt -3
• Opening moneyline: Vanderbilt TBA/Missouri TBA
• Opening total: Over/Under 52.5 points scored
• Time: 3:30 p.m. ET Saturday (ESPN)

EARLY WEEK UPDATE: Vanderbilt has already inched out to a field-goal favorite in Borgata Sports' college football odds Week 9 market.

"We opened the Commodores as 2.5-point home favorites and were quickly bet up to -3," Borgata sportsbook director Tom Gable said Monday night. "Vanderbilt is off a big win against LSU, but they continue the tough SEC grind with this matchup against Missouri.

"I haven’t seen a Vanderbilt football team playing at this level in my lifetime. Vandy is now squarely in the College Football Playoff conversation."

OPENING ODDS UPDATE: No. 10 Vanderbilt (6-1 SU/5-2 ATS) kept its name firmly in the College Football Playoff conversation in Week 8. The Commodores were 1.5-point home favorites vs. LSU and won 31-24, behind Heisman candidate QB Diego Pavia.

No. 15 Missouri (6-1 SU/5-2 ATS) barely got out of Auburn with a victory. The Tigers closed as 1.5-point favorites and were stretched to double overtime, winning 23-17 on quarterback Beau Pribula's 3-yard touchdown run.

Circa Sports opened Vandy -3 in its Week 9 college football odds. There was a brief dip to Commodores -2.5, then the line returned to -3 just before 2 p.m. ET Sunday.

Texas A&M vs. LSU Odds

• Opening point spread: Texas A&M -1
• Opening moneyline: Texas A&M TBA/LSU TBA
• Opening total: Over/Under 49.5 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

EARLY WEEK UPDATE: Texas A&M opened as 2.5-point road chalk in Borgata Sports' college football Week 9 odds. That number is unchanged as of Tuesday afternoon.

"Rumors continue to swirl around the future of Brian Kelly at LSU, after its loss to Vanderbilt on Saturday," Borgata sportsbook director Tom Gable said. "And things don’t get any easier for Kelly and the Tigers this weekend.

"There hasn’t been any change to the spread, but the total has dropped to 47.5."

That's down a point from the 48.5 opener.

OPENING ODDS UPDATE: No. 3 Texas A&M (7-0 SU/3-4 ATS) barely hung on to its unblemished record in a shootout at Arkansas. The Aggies built double-digit leads multiple times but ultimately eked out a 45-42 victory giving 7.5 points.

No. 20 LSU (5-2 SU/3-4 ATS) saw its climb to the SEC title game and/or the College Football Playoff get much harder in Week 8. The Tigers fell short to Vanderbilt 31-24 catching 1.5 points on the road.

Texas A&M opened as 1-point road chalk in Circa Sports' college football odds Week 9 market. In short order, by 2 p.m. ET Sunday, the Aggies moved out to -2.5. The total nudged from 49.5 to 49.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson