2025 College Football Odds Week 4: Lines, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

11 minute read

The College Football Odds Week 4 market has a handful of noteworthy games. Among those are an SEC battle among ranked teams and a Top 25 matchup in the Big Ten, as well.

Auburn vs. Oklahoma is arguably the most attractive contest in college football Week 4 odds. Illinois vs. Indiana is another worthy clash, under the Saturday night lights.

Here’s everything you need to know about college football odds Week 4: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 4 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Rick Osentoski/Imagn Images)

2025 College Football Odds for Week 4

Auburn vs. Oklahoma Odds

• Opening point spread: Oklahoma -6
• Opening moneyline: Oklahoma -225/Auburn +195
• Opening total: Over/Under 52.5 points scored
• Time: 3:30 p.m. ET Saturday (ABC)

GAME DAY UPDATE: With 75 minutes until kickoff, Oklahoma is -6.5 (-115) in BetMGM's college football Week 4 odds. The Sooners opened -5.5, quickly went to -6.5, then Thursday got to -7. Oklahoma has been -6.5 at various juice since 1:30 p.m. ET Friday.

In BetMGM's digital wagering (online/mobile), the Sooners are getting 77% of spread bets/72% of spread money.

"Sharps and the public are on Oklahoma this week. We need Auburn to cover +6.5," BetMGM trading manager Seamus Magee said.

The total is at 46.5 (Over -115) from a 48.5 opener, spending time at 47.5 on Wednesday/Thursday. Magee said there's not much of a decision on the total.

LATE WEEK UPDATE: ESPNBET has been at some iteration of Oklahoma -6.5 most of the week, save for a couple brief Thursday trips to -7.5. The Sooners are now -6.5, but juiced to -125.

Oklahoma is drawing 70% of early spread tickets/53% of early spread money, accounting for all bet types (straight/parlays etc.).

ESPNBET opened the total at 49.5 and bottomed out at 47.5 (Over -115) on Tuesday. The number rebounded to 48.5 by early Friday afternoon, and as of 4 p.m. ET Friday, it's at 47.5 (Under -120). The Under is nabbing 54% of bets and a lopsided 82% of dollars.

By money wagered, Auburn-Oklahoma is the most-bet game in ESPNBET's college football odds Week 4 market.

MIDWEEK UPDATE: As of Thursday afternoon, Oklahoma is out to a 7-point home favorite in DraftKings' Week 4 college football odds. On Sunday afternoon, the Sooners opened -5.5, and they got to -7 by late Sunday night.

Since then, the number has toggled between Sooners -7/-6.5 a couple times. It is all Oklahoma on the spread, with early tickets 4/1-plus and early money beyond 9/1.

The total just reached its low point of 46.5, after opening 49.5 and making stops at 48.5/47.5 along the way. Still, ticket count is 3/1-plus and money almost 2/1 on the Over.

EARLY WEEK UPDATE: Home favorite Oklahoma saw money right out of the gate in Borgata Sports' college football Week 4 odds.

"Oklahoma opened at -5.5, and we took a few limit bets immediately laying the 5.5 and 6. The line now sits at Sooners -6.5," Borgata sportsbook director Tom Gable said.

The total is up a point to 49.5 from a 48.5 opener.

"Some early money on the Over has pushed this up," Gable said.

OPENING ODDS UPDATE: No. 11 Oklahoma (3-0 SU/2-1 ATS) is moving up the rankings while QB John Mateer surges up the Heisman Trophy odds board. In Week 3, the Sooners dumped Temple 42-3 as 24-point road faves.

No. 22 Auburn (3-0 SU/1-2 ATS) hasn't been pressed yet this season, but also hasn't cashed in its last two games. The Tigers topped South Alabama 31-15, but couldn't cover the 26.5-point spread at home.

Oklahoma hit Circa Sports' college football Week 4 odds market at -6, with no early movement. However, the total quickly went from 52.5 to 49.5.

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Michigan vs. Nebraska Odds

• Opening point spread: Michigan -1.5
• Opening moneyline: Michigan -138/Nebraska +118
• Opening total: Over/Under 42.5 points scored
• Time: 3:30 p.m. ET Saturday (CBS)

GAME DAY UPDATE: An hour before kickoff, Michigan is -1 (-105) in BetMGM's Week 4 college football odds. On Sunday, the Wolverines opened -1.5, and they climbed to -2.5 by Monday morning. The line dipped to Michigan -1.5 (-115)/-1.5 (-105) Friday, then to -1 this morning.

"We took a couple big bets on Nebraska +1.5. So as it stands, we're rooting for Michigan by 2 or more," BetMGM trading manager Seamus Magee said. "But a lot can change. I wouldn't be shocked if we see a lot of Michigan money come to the counter before kick.

"We're looking for Under 47.5, too."

BetMGM's total opened at 44.5 and is now 47.5 (Over -115), with stops during the week at 45.5/46.5.

MIDWEEK UPDATE: Michigan has been stable at -2.5 since Monday in DraftKings' college football odds Week 4 market. The Wolverines opened -1.5 Sunday afternoon. Michigan is landing 71% of early spread bets/65% of early spread money.

DK's total opened at 44.5 and twice got to 46.5, where it sits now. The Over is netting 79% of bets/81% of money so far.

EARLY WEEK UPDATE: Michigan opened a slim 1.5-point road favorite in Borgata's Week 4 college football odds, in the Big Ten opener for both teams.

"Michigan took some early money laying the 1.5, and the line now sits at Wolverines -2.5," Borgata sportsbook director Tom Gable said.

The total is also up a point, from 44.5 to 45.5.

OPENING ODDS UPDATE: No. 21 Michigan (2-1 SU/1-2 ATS) fell to Oklahoma 24-13 as a 4-point road 'dog in Week 2. The Wolverines got a breather in Week 3 against Central Michigan, rolling to a 63-3 victory as 27.5-point home favorites.

Nebraska (3-0 SU/2-1 ATS) has faced two consecutive cupcakes ahead of its Big Ten opener. In Week 3, the Huskers hammered FCS outfit Houston Christian 59-7 laying 49.5 points at home.

Michigan opened as 1.5-point road favorite in Circa Sports' Week 4 college football odds. That number is stable early, but the total advanced from 42.5 to 44 in short order Sunday afternoon.

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South Carolina vs. Missouri Odds

• Opening point spread: Missouri -7
• Opening moneyline: Missouri TBA/South Carolina TBA
• Opening total: Over/Under 49 points scored
• Time: 7 p.m. ET Saturday (ESPN)

LATE WEEK UPDATE: South Carolina QB LaNorris Sellers on Friday was declared probable for Saturday's game. BetMGM had already anticipated that and was down to Missouri -9.5 (-115) Thursday afternoon.

That's after opening Mizzou -11.5 and quickly going to -13/-13.5 Sunday. By Tuesday, the Tigers were back to -11.5 (-115), and they went to -10.5 late Wednesday night. Missouri is taking 74% of spread bets, but spread money is much closer, at 54% on the Tigers.

The total also adjusted due to Sellers' status. BetMGM opened at 46.5, went to 47.5 Tuesday and 48.5 (Over -115) Thursday. The number is now 48.5 flat, with 62% of bets/67% of money on the Over.

MIDWEEK UPDATE: On Wednesday, there was optimistic news that South Carolina QB LaNorris Sellers will play Sunday. He's still questionable after a hit to the head took him out of a Week 3 blowout loss to Vanderbilt.

Oddsmakers reacted accordingly, with DraftKings Sportsbook getting as low as Missouri -9.5. The Tigers opened -11.5 Sunday and quickly stretched out to -13.5. As of Thursday afternoon, Mizzou is -10.5 (-105), while taking 55% of early spread bets/73% of early spread money.

The total climbed from 46.5 to 47.5 Tuesday, then to 48.5 (Under -115) Wednesday. The Over is grabbing 87% of tickets/61% of money so far.

EARLY WEEK UPDATE: Missouri continues to be on the rise in college football odds for Week 4.

"Missouri opened as an 11.5-point home favorite and was quickly bet up to -13. It has since moved up to 13.5," Borgata Sports sportsbook director Tom Gable said Monday night. "Obviously, the injury to South Carolina quarterback LaNorris Sellers is hanging over this game.

"If Sellers can’t go, this number will definitely go higher. We should find out more regarding his status on Wednesday."

Sellers suffered a head injury in the Gamecocks' Week blowout loss to Vanderbilt.

Borgata's total is steady at 46.5.

OPENING ODDS UPDATE: No. 23 Missouri (3-0 SU and ATS) made it to SEC play unscathed so far. In Week 3, the Tigers hammered Louisiana-Lafayette 52-10 laying 27.5 points at home.

South Carolina (2-1 SU/1-2 ATS) wasn't as fortunate. The Gamecocks closed as 3-point home favorites vs. Vanderbilt and got trucked 31-7. South Carolina tied it at 7 in the first quarter and didn't score again.

In the Gamecocks' defense, quarterback LaNorris Sellers exited late in the first half after suffering a head injury on a play that drew a targeting penalty. South Carolina was ranked No. 11 last week and is now out of the Top 25.

South Carolina vs. Missouri was a very fast mover early in Circa Sports' college football odds Week 4 market. Mizzou opened -7 and quickly got blasted to -11. And it wasn't done climbing, with the Tigers up to -13 as of 4:30 p.m. ET Sunday.

The total sped from 49 to 48, then straight to 46 within a few minutes. The number then stabilized at 46.5.

Florida vs. Miami Odds

• Opening point spread: Miami -8.5
• Opening moneyline: Miami -270/Florida +230
• Opening total: Over/Under 55 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

MIDWEEK UPDATE: DraftKings Sportsbook opened Miami -8.5 and briefly got to -9.5 Sunday evening. But that number quickly receded to -8.5/-7.5, and it's been stable at -7.5 since Sunday night.

That said, early spread play is all Hurricanes, at 82% of tickets/93% of money.

DK's total has been at 50.5 (Over -118) since Tuesday afternoon, after opening at 52.5 and spending time at 51.5. The Over is getting 69% of tickets/74% of money.

EARLY WEEK UPDATE: Miami opened -8.5 and is down to -7.5 on Borgata Sports' college football Week 4 odds board.

"Florida took a decent amount of money last week against LSU, and the Gators have taken the very early money in this matchup with Miami," Borgata sportsbook director Tom Gable said Monday night.

The total is at 51.5 after opening at 52.5.

OPENING ODDS UPDATE: No. 4 Miami (3-0 SU/2-1 ATS) halted the short Cinderella run of South Florida in Week 3. The Hurricanes closed as 17.5-point favorites and breezed to a 49-12 victory.

Florida stunningly lost at home to South Florida in Week 2, then had to travel to top-10 outfit LSU in Week 3. The Gators (1-2 SU and ATS) hung around, but lost 20-10 catching 4 points.

Miami opened as an 8.5-point favorite in Circa's college football Week 4 odds, with a total of 52. The Hurricanes quickly went to -9, while the total dropped 3 points to 52.

The game went up at 1:36 p.m. ET, with no movement in the first 45 minutes on the spread or total.

Illinois vs. Indiana Odds

• Opening point spread: Indiana -5.5
• Opening moneyline: Indiana -185/Illinois +160
• Opening total: Over/Under 49.5 points scored
• Time: 7:30 p.m. ET Saturday (NBC)

MIDWEEK UPDATE: Indiana opened -3.5 and gradually made its way to -6 by Wednesday afternoon in DraftKings' college football odds Week 4 market. There's been no movement since, with 69% of spread bets on Illinois and 54% of spread dollars on Indiana.

The total is painted to 52.5 at DraftKings, with 78% of bets/64% of cash on the Over.

EARLY WEEK UPDATE: Borgata Sports opened Indiana -4.5, with a total of 52.5, and there's been no movement with either so far.

"After the cupcakes that Indiana has played thus far, this game should attract some decent handle, with it being a prime-time Big Ten opener between two ranked teams," Borgata sportsbook director Tom Gable said.

OPENING ODDS UPDATE: No. 19 Indiana (3-0 SU/2-1 ATS) had the closest thing a team could have to a bye in Week 3. The Hoosiers faced FCS foe Indiana State and ran up the score in a 73-0 shutout as 47.5-point home favorites.

No. 9 Illinois (3-0 SU and ATS) didn't have that kind of offensive output, but still breezed in Week 3. The Fighting Illini blanked Western Michigan 38-0 laying 27.5 points at home.

Indiana opened as 5.5-point chalk in Circa Sports' college football odds Week 4. That number quickly adjusted to Hoosiers -5, then dropped to -4. The total moved from 49.5 to 51.5 right out of the gate Sunday afternoon.

Texas Tech vs. Utah Odds

• Opening point spread: Utah -4
• Opening moneyline: Utah -168/Texas Tech +148
• Opening total: Over/Under 58 points scored
• Time: Noon ET Saturday (FOX)

GAME DAY UPDATE: The Utes opened -3.5 (-115) at BetMGM, and 45 minutes before kickoff, they're -3.5 (-105). In between, Utah went to -3 Tuesday and -3 (-118 Wednesday), then this morning climbed to -3.5 (-105) in college football Week 4 odds.

Utah is getting the bulk of spread support, but Texas Tech is drawing moneyline play.

"The best result for the house is a Utah win and Texas Tech covering +3.5. But we'd get a lot of parlays crushed if it's Texas Tech outright," BetMGM trading manager Seamus Magee said.

The total opened at 55.5 and is up to 57.5.

"Sharp play on the Over this week. And the public likes Over 57.5, too, so we'd like to see this one stay under the total," Magee said.

LATE WEEK UPDATE: Utah opened -4.5 Sunday and bottomed out at -3.5 (even) Thursday in ESPNBET's college football odds Week 4 market. As of 4 p.m. ET Friday, the Utes are -3.5 (-105).

The drop is reflected in the action, as Texas Tech is taking 62% of spread bets/79% of spread money, accounting for all bet types (straight/parlays etc.).

ESPNBET opened the total at 56.5, peaked at 58.5 multiple times and now sits at 57.5 (Over -120). Ticket count is almost even and 67% of money is actually on the Under, again accounting for all bet types.

MIDWEEK UPDATE: Utah is 3-point chalk Thursday afternoon in DraftKings Sportsbook's college football Week 4 odds. That's down from Sunday's -4 opener, with the Utes spending time Monday/Tuesday at various iterations of -3.5.

It's two-way spread play with a lean toward Utah so far, at 52% of tickets/54% of dollars. However, moneyline bettors are leaning toward road 'dog Texas Tech, at 55% of tickets/66% of money.

DK's total is at 56.5, up from the 55.5 opener but down from the Monday/Tuesday high point of 58.5 (Under -115). Still, 71% of early tickets/73% of early dollars are on the Over.

EARLY WEEK UPDATE: Borgata Sports, a BetMGM shop in Atlantic City, opened Utah -3.5 in the college football odds Week 4 market.

"No movement on the side yet. But this game should tell us a lot about both of these teams, who cruised through their nonconference schedule," Borgata sportsbook director Tom Gable said Monday night.

The total climbed from 55.5 to 57.5.

OPENING ODDS UPDATE: No. 16 Utah (3-0 SU and ATS) has three blowout wins to its credit to start the season. The Utes had no trouble Saturday at Wyoming, rolling 31-6 to narrowly cover as 24.5-point favorites.

Likewise, No. 17 Texas Tech (3-0 SU/2-1 ATS) hasn't yet been challenged. The Red Raiders flattened Oregon State 45-14 in Week 3, cashing as 24.5-point home favorites. Week 4 marks Tech's first road game of the season.

Utah opened as a 4-point favorite, with a total 57 in Circa's college football Week 4 odds. The spread is stable as of 4:45 p.m. ET Sunday, three hours after opening. But the total is already down to 55.5, with a stop at 57 along the way.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson