TCU Horned Frogs Odds
| Date | Opp | Close | Result | ATS/OU |
| Sep 1, 2025 | @North Carolina | -3.5
/ 54.5 | Won 48-14 | Won /
Over |
| Sep 13, 2025 | Abilene Christian | -42.5
/ 60.5 | Won 42-21 | Lost /
Over |
| Sep 20, 2025 | SMU | -6.5
/ 63.5 | Won 35-24 | Won /
Under |
| Sep 26, 2025 | @Arizona State | -
/ | | 9:00 PM ET |
| Oct 4, 2025 | Colorado | -
/ | | 7:30 PM ET |
| Oct 11, 2025 | @Kansas State | -
/ | | 12:00 PM ET |
| Oct 18, 2025 | Baylor | -
/ | | 12:00 PM ET |
| Oct 25, 2025 | @West Virginia | -
/ | | 12:00 PM ET |
| Nov 8, 2025 | Iowa State | -
/ | | 1:00 PM ET |
| Nov 15, 2025 | @BYU | -
/ | | 1:00 PM ET |
| Nov 22, 2025 | @Houston | -
/ | | 1:00 PM ET |
| Nov 29, 2025 | Cincinnati | -
/ | | 1:00 PM ET |
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