USC vs. Michigan Odds: Trojans Favorites in College Football Week 4 Lines
USC vs. Michigan odds might make you think of a Rose Bowl matchup. But no, this is still September. Oh, and USC is now in the Big Ten with Michigan, to make things even more confusing.
Southern Cal heads to Ann Arbor as a favorite in odds for USC Trojans vs. Michigan Wolverines. Defending national champion and 18th-ranked Michigan already has one home loss, to Texas, and can't afford another to No. 11 USC.
Here's everything you need to know about USC vs. Michigan odds: opening lines, spreads and betting trends on the game, as multiple oddsmakers provide insights on college football Week 4 odds and action.
Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.
USC vs. Michigan Live Odds
| 🏈 USC vs Michigan | 🤑 Spread | 💸 Moneyline | 📈 Total |
| USC | -5.5 (-110) | -210 | O 44 (-110) |
| Michigan | +5.5 (-110) | +175 | U 44 (-110) |
USC vs. Michigan Line Moves, Betting
USC @ MICH Odds
| Time | Open | Bet365 | BetMGM | ESPNBet | Caesars | DraftKings | FanDuel | BallyBet | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open |  › |  › |  › |  › |  › |  › |  › |  › |  | ||
 387 USC | +10.5 -110 | -5.5 -110 | -6 even | -5 -110 | -5.5 -110 | -5 -110 | -5.5 -110 | -5.5 -112 | -5.5 -110 | -6 even | |
 388 Michigan | -10.5 -110 | +5.5 -110 | +6 -120 | +5 -110 | +5.5 -110 | +5 -110 | +5.5 -110 | +5.5 -112 | +5.5 -110 | +6 -120 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | o45.5 -110 | o44 -110 | o44 -110 | o44.5 -105 | o44 -110 | o44 -110 | o44.5 -105 | o44.5 -110 | o44.5 -109 | o44 -110 | |
| 388 Michigan | u45.5 -110 | u44 -110 | u44 -110 | u44.5 -115 | u44 -110 | u44 -110 | u44.5 -115 | u44.5 -113 | u44.5 -112 | u44 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +270 | -210 | -210 | -215 | -210 | -198 | -215 | -250 | -235 | -210 | |
| 388 Michigan | -350 | +175 | +170 | +180 | +175 | +164 | +176 | +180 | +180 | +170 | |
| Time | Open | Bet365 | BetMGM | ESPNBet | Caesars | DraftKings | FanDuel | BallyBet | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +10.5 -110 | -3 -110 | -3 -110 | -3.5 even | -3 -110 | -3.5 +102 | -3.5 -110 | -3.5 -109 | -3.5 -105 | -6 even | |
| 388 Michigan | -10.5 -110 | +3 -110 | +3 -110 | +3.5 -120 | +3 -110 | +3.5 -122 | +3.5 -110 | +3.5 -125 | +3.5 -125 | +6 -120 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | o45.5 -110 | o22.5 -105 | N/A | N/A | o22.5 -110 | o22.5 -110 | o22.5 -112 | o21.5 -110 | o21.5 -109 | o44 -110 | |
| 388 Michigan | u45.5 -110 | u22.5 -115 | N/A | N/A | u22.5 -110 | u22.5 -110 | u22.5 -110 | u21.5 -121 | u21.5 -120 | u44 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +270 | -180 | -185 | -180 | -178 | -180 | -196 | -215 | -205 | -210 | |
| 388 Michigan | -350 | +150 | +150 | +140 | +150 | +150 | +158 | +150 | +150 | +170 | |
| Time | Open | Bet365 | BetMGM | ESPNBet | Caesars | DraftKings | FanDuel | BallyBet | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +10.5 -110 | N/A | N/A | N/A | N/A | -2.5 -120 | N/A | N/A | N/A | -6 even | |
| 388 Michigan | -10.5 -110 | N/A | N/A | N/A | N/A | +2.5 even | N/A | N/A | N/A | +6 -120 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | o45.5 -110 | N/A | N/A | N/A | N/A | o21.5 -105 | N/A | N/A | N/A | o44 -110 | |
| 388 Michigan | u45.5 -110 | N/A | N/A | N/A | N/A | u21.5 -115 | N/A | N/A | N/A | u44 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +270 | N/A | N/A | N/A | N/A | -180 | N/A | N/A | N/A | -210 | |
| 388 Michigan | -350 | N/A | N/A | N/A | N/A | +150 | N/A | N/A | N/A | +170 | |
| Time | Open | Bet365 | BetMGM | ESPNBet | Caesars | DraftKings | FanDuel | BallyBet | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +10.5 -110 | -0.5 -115 | -0.5 -115 | -0.5 -105 | -0.5 -110 | -0.5 -105 | -1.5 -106 | -0.5 -108 | -0.5 -108 | -6 even | |
| 388 Michigan | -10.5 -110 | +0.5 -115 | +0.5 -110 | +0.5 -125 | +0.5 -110 | +0.5 -115 | +1.5 -118 | +0.5 -129 | +0.5 -121 | +6 -120 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | o45.5 -110 | o10 -110 | N/A | o9.5 -120 | o10 -105 | o9.5 -122 | o9.5 -112 | o9.5 -122 | o9.5 -121 | o44 -110 | |
| 388 Michigan | u45.5 -110 | u10 -120 | N/A | u9.5 -110 | u10 -115 | u9.5 +102 | u9.5 -112 | u9.5 -109 | u9.5 -108 | u44 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +270 | -165 | -190 | -170 | -160 | -166 | -186 | -186 | -186 | -210 | |
| 388 Michigan | -350 | +135 | +145 | +135 | +135 | +140 | +144 | +135 | +140 | +170 | |
| Time | Open | Bet365 | BetMGM | ESPNBet | Caesars | DraftKings | FanDuel | BallyBet | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +10.5 -110 | N/A | N/A | N/A | N/A | -2.5 -115 | -1.5 -106 | N/A | N/A | -6 even | |
| 388 Michigan | -10.5 -110 | N/A | N/A | N/A | N/A | +2.5 -115 | +1.5 -118 | N/A | N/A | +6 -120 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | o45.5 -110 | N/A | N/A | N/A | N/A | o13.5 -120 | o13.5 -102 | N/A | N/A | o44 -110 | |
| 388 Michigan | u45.5 -110 | N/A | N/A | N/A | N/A | u13.5 -110 | u13.5 -122 | N/A | N/A | u44 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +270 | N/A | N/A | N/A | N/A | -175 | -164 | N/A | N/A | -210 | |
| 388 Michigan | -350 | N/A | N/A | N/A | N/A | +135 | +128 | N/A | N/A | +170 | |
| Time | Open | Bet365 | BetMGM | ESPNBet | Caesars | DraftKings | FanDuel | BallyBet | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +10.5 -110 | N/A | N/A | N/A | N/A | -0.5 -105 | -1.5 +120 | N/A | N/A | -6 even | |
| 388 Michigan | -10.5 -110 | N/A | N/A | N/A | N/A | +0.5 -125 | +1.5 -150 | N/A | N/A | +6 -120 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | o45.5 -110 | N/A | N/A | N/A | N/A | o9.5 -115 | o9.5 -120 | N/A | N/A | o44 -110 | |
| 388 Michigan | u45.5 -110 | N/A | N/A | N/A | N/A | u9.5 -115 | u9.5 -104 | N/A | N/A | u44 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +270 | N/A | N/A | N/A | N/A | -166 | -146 | N/A | N/A | -210 | |
| 388 Michigan | -350 | N/A | N/A | N/A | N/A | +130 | +114 | N/A | N/A | +170 | |
| Time | Open | Bet365 | BetMGM | ESPNBet | Caesars | DraftKings | FanDuel | BallyBet | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +10.5 -110 | N/A | N/A | N/A | N/A | -0.5 -120 | -1.5 +118 | N/A | N/A | -6 even | |
| 388 Michigan | -10.5 -110 | N/A | N/A | N/A | N/A | +0.5 -110 | +1.5 -148 | N/A | N/A | +6 -120 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | o45.5 -110 | N/A | N/A | N/A | N/A | o13.5 -110 | o10.5 -102 | N/A | N/A | o44 -110 | |
| 388 Michigan | u45.5 -110 | N/A | N/A | N/A | N/A | u13.5 -120 | u10.5 -122 | N/A | N/A | u44 -110 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 387 USC | +270 | N/A | N/A | N/A | N/A | -160 | -146 | N/A | N/A | -210 | |
| 388 Michigan | -350 | N/A | N/A | N/A | N/A | +124 | +114 | N/A | N/A | +170 | |
- Opening point spread: USC -6
- Opening moneyline: USC -225/Michigan +190
- Opening total: Over/Under 46.5 points scored
- Time: 3:30 p.m. ET Saturday (CBS)
USC is already coming off a bye, taking Week 3 off after opening 2-0 SU and ATS. In Week 1, the Trojans notched an impressive 27-20 win catching 4 points against LSU, in a neutral-site game in Las Vegas.
Southern Cal followed with a much easier 48-0 rout of Utah State, with USC giving 31 points at home.
Michigan got flattened by Texas in Week 2, losing 31-12 as 6.5-point road underdogs. In Week 3, the Wolverines had Arkansas State in a 28-3 hole early in the fourth quarter, then let off the gas. Michigan won 28-18, but didn't cash as a 21.5-point home favorite.
TwinSpires Sportsbook opened the Trojans -5.5 and moved to -6 on the USC vs. Michigan odds board. On Thursday afternoon, the line is back at Southern Cal -5.5, with 75% of early spread tickets/82% of early spread money on the Trojans.
"It feels like nobody wants to back Michigan after the Week 2 performance vs. Texas. We'll be big fans of the Wolverines to at least get a cover for us," TwinSpires director of retail sports Zachary Lucas said.
The total opened at 46 and is down to 44.5, with a stop at 45 on the way. The Under is seeing 59% of tickets/52% of money.
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