Cleveland Guardians vs. Chicago White Sox Picks, Predictions, Odds

Cleveland Guardians vs. Chicago White Sox Betting Analysis

Cleveland and Chicago meet up for the first of a four-game series on Friday, July 22, 2022 at Guaranteed Rate Field.

Despite posting a 21-25 record away from Progressive Field, Cleveland is in second place in the American League Central with an overall record of 46-44, which trails the first placed Minnesota Twins by two games. Chicago is currently positioned third in the American League Central standings with records of 46-46 overall and 19-25 at home, putting the White Sox three games back for the division lead.

Updated on 11/21/2024

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Cleveland Guardians vs. Chicago White Sox Betting Prediction

Cleveland enters this matchup second in the AL Central standings, two games behind the Minnesota Twins for first place. The Guardians won six of their last 10 games prior to the All-Star break and gained some crucial ground on the Twins in the race for the NL Central. Cleveland ranks amongst the middle of the league in terms of offense with a batting average of .249 (9th), on base percentage of .314 (16th), slugging percentage of .384 (19th), and 391 total runs (17th). The bullpen has been solid on the season with a team ERA of 3.87 (14th). Right-handed pitcher Cal Quantrill (6-5, 3.75 ERA) is expected to take the mound Friday.  

The White Sox are currently third in the AL Central standings, three games behind the Minnesota Twins for first place. Chicago was on a roll before the All-Star break, winning seven of their last 10 games and gaining four-games on the Twins over that stretch. The offense has been subpar in the first half of the season with a batting average of .257 (3rd), on base percentage of .311 (19th), slugging percentage of .385 (18th), and 406 total runs (T-14th). Chicago’s bullpen has struggled at times and have a team ERA of 3.98 (19th) after 92 games played. The right-hander Lucas Giolito (6-5, 4.69 ERA) is scheduled to get the start on Friday.  

The Guardians have won six of nine games against the White Sox this season and are still (+135) underdogs. I like the value in that considering these teams are evenly matched and Cleveland is at home. Quantrill has been the better pitcher throughout the season, but Giolito has pitched very well against the Guardians twice this season, giving up a combined two runs in 13.1 innings of work. Regardless, backing Cleveland moneyline here as it offers the best value on the board.  

Score Prediction: Guardians 5, White Sox 4 
Best Bet: Guardians ML (+130)

Cleveland Guardians vs. Chicago White Sox Betting Odds

Cleveland Guardians vs. Chicago White Sox Betting Resources

• Date: Friday, July 22, 2022
• Matchup: AL Central
• Venue: Guaranteed Rate Field
• Location: Chicago, Illinois
• Time-TV: 8:10 p.m. ET – MLB.tv

Cleveland Guardians vs. Chicago White Sox – Current Form

The Guardians were tripped up by the Kansas City Royals last Sunday, but grabbed three of three games last Saturday against the Tigers. Their best performance was on Thursday, when they limited the Tigers to scoring no runs in the first contest of a three-game series. Cleveland cruised past the Kansas City Royals on Saturday by plating 13 runs in the second of a game of the series. The White Sox split the series against the Tigers last Sunday with 2-2, but climbed back up by winning against the Twins last Sunday. They kept the Minnesota Twins from scoring any runs in the fourth contest of the series on Sunday. Scoring 12 runs against the Minnesota Twins on Thursday’s first game in the series was their best performance in their last eight games.

Cleveland Guardians vs. Chicago White Sox – Pitching Matchup

Cleveland: Cal Quantrill (7-5, 3.75 ERA)

Cleveland’s right-hander Cal Quantrill takes the mound for his 17th start of the season. Quantrill looks to improve on a 7-5 record and 3.75 ERA in 100.2 innings, while striking out 63, walking 30 batters, and posting a 1.29 WHIP. Cleveland’s 27-year-old right-hander earned the win in his last start, which came at home against the Detroit Tigers July 16, 2022. He threw six innings, not allowing any runs on four hits with two walks and five strikeouts in a 10-0 the Guardians victory. In his seven starts on the road this season, Quantrill is 2-5 with a 4.66 ERA, a 1.58 WHIP, 14 walks and 22 strikeouts over 38.2 innings of work.

Chicago: Lucas Giolito (6-5, 4.69 ERA)

Lucas Giolito will make his 16th start of the season for Chicago, who’s hoping to find some traction after posting a 6-5 record and 4.69 ERA thus far, while tallying a 1.40 WHIP, 32 walks, and 102 strikeouts across 88.1 innings of action. Giolito grabbed the win in his last start, which came on the road against the Cleveland Guardians on July 13, 2022. He allowed one run on five hits with one walk and five strikeouts in an eventual 1-2 the White Sox win. In six home starts this season, Giolito has compiled a 2-3 record in 35.2 innings, while striking out 38, walking 12 batters, and putting together a 5.30 ERA and a 1.46 WHIP.

Cleveland Guardians vs. Chicago White Sox – Series History

The White Sox notched a 10-9 mark in this series during the 2021 campaign. The Guardians have won six of nine contests against the White Sox this season.