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Featured Last Updated Oct 10 2025, 10:15 AM

NFL: San Francisco 49ers vs. Tampa Bay Buccaneers: Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: San Francisco 49ers vs. Tampa Bay Buccaneers: Prediction, Odds, Best Bet

Featured Image Credit: Nathan Ray Seebeck-Imagn Images

SF @ TB Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
San Francisco 49ers 265 49ers
+1.5 -110 +2.5 -110 +2.5 -110 +3.5 -115 +2.5 -110 +2.5 -110 +2.5 -105 +3.5 -120 +1.5 -105 +3.5 -125 +3.5 -105  
Tampa Bay Buccaneers 266 Buccaneers
-1.5 -110 -2.5 -110 -2.5 -110 -3.5 -105 -2.5 -109 -2.5 -120 -2.5 -115 -3.5 -110 -1.5 -115 -3.5 +102 -3.5 -115  
San Francisco 49ers 265 49ers
o48.5 -115 o23.5 -105 N/A o23.5 -105 o23.5 -107 N/A o23.5 -110 o23.5 -115 o22.5 -135 o23.5 -106 o47.5 -102  
Tampa Bay Buccaneers 266 Buccaneers
u48.5 -105 u23.5 -115 N/A u23.5 -115 u23.5 -115 N/A u23.5 -110 u23.5 -115 u22.5 +110 u23.5 -118 u47.5 -118  
San Francisco 49ers 265 49ers
+102 +130 +135 +164 +130 +135 +134 N/A +130 +160 +160  
Tampa Bay Buccaneers 266 Buccaneers
-122 -155 -160 -198 -159 -180 -162 N/A -160 -205 -185  
San Francisco 49ers 265 49ers
+1.5 -110 +0.5 -135 +0.5 -150 +0.5 -130 N/A +0.5 -140 +1.5 -138 +2.5 -105 +1.5 -155 +1.5 -112 +3.5 -105  
Tampa Bay Buccaneers 266 Buccaneers
-1.5 -110 -0.5 +115 -0.5 +115 -0.5 +110 N/A -0.5 +110 -1.5 +114 -2.5 -125 -1.5 +115 -1.5 -112 -3.5 -115  
San Francisco 49ers 265 49ers
o48.5 -115 o9.5 -105 N/A o8.5 -112 N/A o9.5 -120 o9.5 -106 o9.5 -120 o8.5 -120 o9.5 -120 o47.5 -102  
Tampa Bay Buccaneers 266 Buccaneers
u48.5 -105 u9.5 -115 N/A u8.5 -108 N/A u9.5 -110 u9.5 -114 u9.5 -110 u8.5 -110 u9.5 -105 u47.5 -118  
San Francisco 49ers 265 49ers
+102 +120 +115 +120 N/A +110 +124 N/A +120 +163 +160  
Tampa Bay Buccaneers 266 Buccaneers
-122 -140 -145 -142 N/A -140 -148 N/A -160 -205 -185  
San Francisco 49ers 265 49ers
+1.5 -110 +1.5 -105 N/A +1.5 -142 N/A N/A +1.5 -120 N/A N/A +1.5 -141 +3.5 -105  
Tampa Bay Buccaneers 266 Buccaneers
-1.5 -110 -1.5 -115 N/A -1.5 +120 N/A N/A -1.5 -100 N/A N/A -1.5 +114 -3.5 -115  
San Francisco 49ers 265 49ers
o48.5 -115 o23.5 -105 N/A o23.5 -102 N/A N/A o22.5 -120 o23.5 -105 N/A o22.5 -124 o47.5 -102  
Tampa Bay Buccaneers 266 Buccaneers
u48.5 -105 u23.5 -115 N/A u23.5 -118 N/A N/A u22.5 -100 u23.5 -125 N/A u22.5 even u47.5 -118  
San Francisco 49ers 265 49ers
+102 +130 N/A -105 N/A N/A +118 N/A N/A -104 +160  
Tampa Bay Buccaneers 266 Buccaneers
-122 -155 N/A -115 N/A N/A -134 N/A N/A -121 -185  
San Francisco 49ers 265 49ers
+1.5 -110 N/A N/A +0.5 -105 N/A +0.5 -120 +1.5 -122 +0.5 -110 N/A N/A +3.5 -105  
Tampa Bay Buccaneers 266 Buccaneers
-1.5 -110 N/A N/A -0.5 -115 N/A -0.5 -110 -1.5 -100 -0.5 -120 N/A N/A -3.5 -115  
San Francisco 49ers 265 49ers
o48.5 -115 o13.5 -110 N/A o13.5 -118 N/A o13.5 -125 o14.5 +104 o13.5 -125 N/A N/A o47.5 -102  
Tampa Bay Buccaneers 266 Buccaneers
u48.5 -105 u13.5 -110 N/A u13.5 -102 N/A u13.5 -105 u14.5 -126 u13.5 -105 N/A N/A u47.5 -118  
San Francisco 49ers 265 49ers
+102 +135 N/A +130 N/A N/A +124 N/A N/A N/A +160  
Tampa Bay Buccaneers 266 Buccaneers
-122 -160 N/A -155 N/A N/A -150 N/A N/A N/A -185  
San Francisco 49ers 265 49ers
+1.5 -110 N/A N/A +0.5 -135 N/A -0.5 +115 +1.5 -160 -0.5 +120 N/A N/A +3.5 -105  
Tampa Bay Buccaneers 266 Buccaneers
-1.5 -110 N/A N/A -0.5 +114 N/A +0.5 -145 -1.5 +126 +0.5 -160 N/A N/A -3.5 -115  
San Francisco 49ers 265 49ers
o48.5 -115 o9.5 -115 N/A o9.5 -125 N/A o9.5 -130 o9.5 -130 o9.5 -130 N/A N/A o47.5 -102  
Tampa Bay Buccaneers 266 Buccaneers
u48.5 -105 u9.5 -105 N/A u9.5 +102 N/A u9.5 even u9.5 +110 u9.5 even N/A N/A u47.5 -118  
San Francisco 49ers 265 49ers
+102 +120 N/A +114 N/A N/A +108 N/A N/A N/A +160  
Tampa Bay Buccaneers 266 Buccaneers
-122 -140 N/A -135 N/A N/A -132 N/A N/A N/A -185  
San Francisco 49ers 265 49ers
+1.5 -110 +0.5 -125 N/A +0.5 -120 N/A +1.5 -110 +1.5 -140 +1.5 -110 N/A N/A +3.5 -105  
Tampa Bay Buccaneers 266 Buccaneers
-1.5 -110 -0.5 +105 N/A -0.5 even N/A -1.5 -120 -1.5 +116 -1.5 -120 N/A N/A -3.5 -115  
San Francisco 49ers 265 49ers
o48.5 -115 o14 -110 N/A o13.5 -102 N/A o13.5 even o12.5 -128 o13.5 +105 N/A N/A o47.5 -102  
Tampa Bay Buccaneers 266 Buccaneers
u48.5 -105 u14 -110 N/A u13.5 -118 N/A u13.5 -130 u12.5 -128 u13.5 -135 N/A N/A u47.5 -118  
San Francisco 49ers 265 49ers
+102 +105 N/A +105 N/A N/A +110 N/A N/A N/A +160  
Tampa Bay Buccaneers 266 Buccaneers
-122 -125 N/A -125 N/A N/A -134 N/A N/A N/A -185  

The 49ers will take on the Buccaneers in this week's NFL action. Kickoff is set for 4:25 p.m. EDT at Raymond James Stadium in Tampa, Fla. The game will be broadcast live on CBS. Here's everything you need to know about 49ers vs. Buccaneers odds, the latest NFL spreads, NFL over/unders and more.

The 49ers will take on the Buccaneers in this week's NFL action. Kickoff is set for 4:25 p.m. EDT at Raymond James Stadium in Tampa, Fla. The game will be broadcast live on CBS. Here's everything you need to know about 49ers vs. Buccaneers odds, the latest NFL spreads, NFL over/unders and more.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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San Francisco 49ers vs. Tampa Bay Buccaneers Best Bet

There is no doubt that Baker Mayfield has been amazing this season. We are through 5 weeks and Baker has led the Bucs to victories with 4 game winning drives. Conversely, Mac Jones has been more than servicable in his time as the 49ers starter in Purdy's absence. It is unclear if Mac Jones or Brock Purdy will start at QB for the 49ers this week, but I am not sure if that decision means much at this point.

Tristan Wirfs has allowed an 11.1% pressure rate in the two games since his return form injury, about 2.5x higher than his career average heading into the season. If this is a reliable data point, this 49ers pass rush could attack a weaker than normal Wirfs and get to Baker. I like San Francisco to keep this one close.

San Francisco 49ers vs. Tampa Bay Buccaneers Best Bet: San Francisco 49ers +3 (+100)

(Pick from Dylan Wilkerson)

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What Time is the San Francisco 49ers vs. Tampa Bay Buccaneers Game?

The San Francisco 49ers vs. Tampa Bay Buccaneers game is at 4:25 PM ET on Sunday, October 12th.

Where is the San Francisco 49ers vs. Tampa Bay Buccaneers Game Being Played?

This game will be played at Raymond James Stadium in Tampa, FL.

How Can I Watch San Francisco 49ers vs. Tampa Bay Buccaneers?

You can watch San Francisco 49ers vs. Tampa Bay Buccaneers on FOX.

Can the 49ers Beat the Buccaneers?

Of course! The 49ers are only a 3-point underdog, anything can happen in the NFL!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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