Sign Up Subscribe
Featured Last Updated Oct 10 2025, 12:35 PM

NFL: Lions vs. Chiefs, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
9 minute read
NFL: Lions vs. Chiefs, Prediction, Odds, Best Bet

Featured Image Credit: Junfu Han via Imagn Images

DET @ KC Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Detroit Lions 273 Lions
+3 -115 +0.5 -110 +0.5 -115 -0.5 even +1.5 -125 +0.5 -125 +1.5 -115 +0.5 -110 +1.5 -125 +1.5 -122 +2.5 -105  
Kansas City Chiefs 274 Chiefs
-3 -105 -0.5 -110 -0.5 -105 +0.5 -120 -1.5 even -0.5 -105 -1.5 -105 -0.5 -110 -1.5 +105 -1.5 -103 -2.5 -115  
Detroit Lions 273 Lions
o48.5 -110 o25.5 -110 N/A o26.5 -102 o24.5 -124 N/A o26.5 -100 o25.5 -110 o24.5 -115 o26.5 -105 o51.5 -115  
Kansas City Chiefs 274 Chiefs
u48.5 -110 u25.5 -110 N/A u26.5 -118 u24.5 even N/A u26.5 -125 u25.5 -110 u24.5 -105 u26.5 -118 u51.5 -105  
Detroit Lions 273 Lions
+130 +115 +105 -120 +110 even +110 N/A +110 +110 +120  
Kansas City Chiefs 274 Chiefs
-155 -135 -125 even -136 -130 -136 N/A -130 -137 -142  
Detroit Lions 273 Lions
+3 -115 +0.5 -140 +0.5 -160 +0.5 -142 N/A +0.5 -145 +1.5 -164 +0.5 -145 +1.5 -170 +1.5 -162 +2.5 -105  
Kansas City Chiefs 274 Chiefs
-3 -105 -0.5 +120 -0.5 +125 -0.5 +120 N/A -0.5 +115 -1.5 +130 -0.5 +120 -1.5 +125 -1.5 +128 -2.5 -115  
Detroit Lions 273 Lions
o48.5 -110 o10 even N/A o9.5 -142 N/A o9.5 -135 o9.5 -128 o9.5 -135 o8.5 -170 o9.5 -134 o51.5 -115  
Kansas City Chiefs 274 Chiefs
u48.5 -110 u10 -120 N/A u9.5 +120 N/A u9.5 +105 u9.5 +106 u9.5 +115 u8.5 +125 u9.5 +108 u51.5 -105  
Detroit Lions 273 Lions
+130 +110 even +114 N/A +105 +106 N/A even +107 +120  
Kansas City Chiefs 274 Chiefs
-155 -130 -125 -135 N/A -135 -128 N/A -130 -132 -142  
Detroit Lions 273 Lions
+3 -115 +0.5 -110 N/A +2.5 -108 N/A N/A +1.5 -120 N/A N/A +1.5 -129 +2.5 -105  
Kansas City Chiefs 274 Chiefs
-3 -105 -0.5 -110 N/A -2.5 -112 N/A N/A -1.5 -100 N/A N/A -1.5 +104 -2.5 -115  
Detroit Lions 273 Lions
o48.5 -110 o25.5 -110 N/A o25.5 -115 N/A N/A o24.5 -115 o26.5 -115 N/A o25.5 -110 o51.5 -115  
Kansas City Chiefs 274 Chiefs
u48.5 -110 u25.5 -110 N/A u25.5 -105 N/A N/A u24.5 -105 u26.5 -115 N/A u25.5 -113 u51.5 -105  
Detroit Lions 273 Lions
+130 even N/A +145 N/A N/A +112 N/A N/A +105 +120  
Kansas City Chiefs 274 Chiefs
-155 -120 N/A -175 N/A N/A -130 N/A N/A -130 -142  
Detroit Lions 273 Lions
+3 -115 N/A N/A +0.5 -135 N/A +0.5 -135 +1.5 -132 +0.5 -135 N/A N/A +2.5 -105  
Kansas City Chiefs 274 Chiefs
-3 -105 N/A N/A -0.5 +114 N/A -0.5 +105 -1.5 +112 -0.5 +105 N/A N/A -2.5 -115  
Detroit Lions 273 Lions
o48.5 -110 o16 -110 N/A o15.5 -115 N/A o15.5 -120 o16.5 -104 o15.5 -120 N/A N/A o51.5 -115  
Kansas City Chiefs 274 Chiefs
u48.5 -110 u16 -110 N/A u15.5 -105 N/A u15.5 -110 u16.5 -116 u15.5 -110 N/A N/A u51.5 -105  
Detroit Lions 273 Lions
+130 +105 N/A -105 N/A N/A +106 N/A N/A N/A +120  
Kansas City Chiefs 274 Chiefs
-155 -125 N/A -115 N/A N/A -134 N/A N/A N/A -142  
Detroit Lions 273 Lions
+3 -115 N/A N/A +0.5 -135 N/A +0.5 -135 +1.5 -154 +0.5 -135 N/A N/A +2.5 -105  
Kansas City Chiefs 274 Chiefs
-3 -105 N/A N/A -0.5 +114 N/A -0.5 +105 -1.5 +128 -0.5 +105 N/A N/A -2.5 -115  
Detroit Lions 273 Lions
o48.5 -110 o10.5 +105 N/A o10.5 +110 N/A o10.5 +105 o10.5 +114 o10.5 +105 N/A N/A o51.5 -115  
Kansas City Chiefs 274 Chiefs
u48.5 -110 u10.5 -125 N/A u10.5 -130 N/A u10.5 -135 u10.5 -136 u10.5 -135 N/A N/A u51.5 -105  
Detroit Lions 273 Lions
+130 +110 N/A +110 N/A N/A +112 N/A N/A N/A +120  
Kansas City Chiefs 274 Chiefs
-155 -130 N/A -130 N/A N/A -140 N/A N/A N/A -142  
Detroit Lions 273 Lions
+3 -115 +0.5 -130 N/A +0.5 -125 N/A +0.5 -130 +1.5 -148 +0.5 -130 N/A N/A +2.5 -105  
Kansas City Chiefs 274 Chiefs
-3 -105 -0.5 +110 N/A -0.5 +105 N/A -0.5 even -1.5 +124 -0.5 even N/A N/A -2.5 -115  
Detroit Lions 273 Lions
o48.5 -110 o14.5 -110 N/A o14.5 -102 N/A o14.5 -105 o13.5 -126 o14.5 -105 N/A N/A o51.5 -115  
Kansas City Chiefs 274 Chiefs
u48.5 -110 u14.5 -110 N/A u14.5 -118 N/A u14.5 -125 u13.5 +104 u14.5 -125 N/A N/A u51.5 -105  
Detroit Lions 273 Lions
+130 even N/A +102 N/A N/A +102 N/A N/A N/A +120  
Kansas City Chiefs 274 Chiefs
-155 -120 N/A -122 N/A N/A -122 N/A N/A N/A -142  

The Lions will take on the Chiefs in this week's NFL action. Kickoff is set for 8:20 p.m. EDT at GEHA Field at Arrowhead Stadium in Kansas City, Mo. The game will be broadcast live on NBC. Here's everything you need to know about Lions vs. Chiefs odds, the latest NFL spreads, NFL over/unders and more.

The Chiefs opened as a -2.5 point favorite over Lions. The total is set at over/under 52.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 10/13/25

bet365
Bet $5, Get $200 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Claim $200
New customers only, 21+ (18+ in KY). Gambling Problem? Call 1-800-GAMBLER. Available in AZ, CO, IA, IL, IN, KS, KY, LA, MD, NC, NJ, OH, PA, TN, VA only. Bet $5 and Get $200 in Bonus Bets at bet365. Registration required. Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. T&Cs, time limits and exclusions apply.

Detroit Lions vs. Kansas City Chiefs Best Bet

I don't think there was anything to be upset about following the Chiefs' loss to the Jaguars on Monday Night Football last week. I covered it in another blurb, but they moved the ball brilliantly even against a vaunted — and I say that tongue-in-cheek — Jags secondary. Patrick Mahomes finished 29-of-41 for 318 yards, and on the ground Kareem Hunt remained effective while Isiah Pacheco finally had some degree of success on the ground.

I'd anticipate we see more of a timeshare in the backfield, and that's only going to mean good things for this offense. Hunt has given this team more than Pacheco, and more than that an established run game will mean Mahomes is able to get the ball out to a very talented group of receivers — and Hollywood Brown as well.

I kid, though Brown did catch just four of his eight targets. This is a good team which deserved to improve to 3-2 and while the defense ranks just around the middle of the league I believe there's still a ton of upward mobility on offense. Best of all, the team appears to be fully healthy aside from the assorted depth pieces on defense who are on IR, and we can't say the same for Detroit.

The Lions are down D.J. Reed at corner — a huge blow — and Amon-Ra St. Brown and Kalif Raymond each haven't participated in practice this week. Detroit may be one of the best passing offenses by DVOA, but it's now in danger of losing its lead man at receiver and will need to come up big here with Kansas City limiting Jacksonville to just 25 passing attempts and just 5.9 yards per play on offense.

This is the Chiefs' game, in my opinion; they're at home on primetime and in a delectable spot after being robbed of a win on Monday.

Lions vs. Chiefs Best Bet: Chiefs ML (-130)

(Pick from Kenny Ducey)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Detroit Lions vs. Kansas City Chiefs Game?

The Detroit Lions vs. Kansas City Chiefs game is at 8:20 PM ET on Sunday, October 12th.

Where is the Detroit Lions vs. Kansas City Chiefs Game Being Played?

This game will be played at GEHA Field at Arrowhead Stadium.

How Can I Watch Lions vs. Chiefs?

You can watch Lions vs. Chiefs on NBC.

Can the Chiefs Beat the Lions?

Yes, it is just the third time in the Patrick Mahomes' era that the Chiefs are underdogs at Arrowhead Stadium. With their backs against the wall, expect KC to come out and play at a high level against the red-hot Lions.

Featured News

Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
•