Sign Up Subscribe
Featured

NFL: New England Patriots vs. Buffalo Bills: Prediction, Odds, Preview

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
NFL: New England Patriots vs. Buffalo Bills: Prediction, Odds, Preview

Featured Image Credit: Joseph Maiorana-Imagn Images

BUF @ NE Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Buffalo Bills 463 Bills
-4.5 -110 -0.5 -110 -0.5 -105 -0.5 +102 +1.5 -145 -1.5 +110 +1.5 -120 +5.5 -120 +1.5 -134 -2.5 -110  
New England Patriots 464 Patriots
+4.5 -110 +0.5 -110 +0.5 -115 +0.5 -120 -1.5 +111 +1.5 -135 -1.5 -110 -5.5 even -1.5 +107 +2.5 -110  
Final
Buffalo Bills 463 Bills
o46.5 -110 o24.5 -105 o24.5 +105 o24.5 -102 o24.5 -104 o25.5 -100 o25.5 -115 o28.5 -120 o24.5 -108 o49.5 -115  
New England Patriots 464 Patriots
u46.5 -110 u24.5 -115 u24.5 -125 u24.5 -118 u24.5 -124 u25.5 -120 u25.5 -115 u28.5 -120 u24.5 -114 u49.5 -105  
Final
Buffalo Bills 463 Bills
-198 -125 -125 -120 -105 -128 N/A +210 even -142  
New England Patriots 464 Patriots
+164 +105 +105 even -127 -100 N/A -325 -124 +120  
Final
Buffalo Bills 463 Bills
-4.5 -110 -0.5 +130 -0.5 +130 -0.5 +124 N/A -1.5 +140 +0.5 -135 +5.5 +105 +1.5 -139 -2.5 -110  
New England Patriots 464 Patriots
+4.5 -110 +0.5 -155 +0.5 -165 +0.5 -148 N/A +1.5 -174 -0.5 +105 -5.5 -140 -1.5 +112 +2.5 -110  
Final
Buffalo Bills 463 Bills
o46.5 -110 o9.5 -130 o9.5 -125 o9.5 -125 N/A o9.5 -132 o9.5 -140 o14.5 +140 o9.5 -136 o49.5 -115  
New England Patriots 464 Patriots
u46.5 -110 u9.5 +110 u9.5 even u9.5 +105 N/A u9.5 +110 u9.5 +110 u14.5 -215 u9.5 +110 u49.5 -105  
Final
Buffalo Bills 463 Bills
-198 -120 -115 -122 N/A -118 N/A +600 +123 -142  
New England Patriots 464 Patriots
+164 even -110 +105 N/A -104 N/A -1200 -155 +120  
Final
Buffalo Bills 463 Bills
-4.5 -110 -0.5 -105 N/A -1.5 -110 N/A -1.5 +110 N/A -2.5 -130 -2.5 -108 -2.5 -110  
New England Patriots 464 Patriots
+4.5 -110 +0.5 -115 N/A +1.5 -120 N/A +1.5 -135 N/A +2.5 +105 +2.5 -115 +2.5 -110  
Final
Buffalo Bills 463 Bills
o46.5 -110 o24 -110 N/A o24.5 -105 N/A o23.5 -120 o24.5 even o24.5 -115 o24.5 -104 o49.5 -115  
New England Patriots 464 Patriots
u46.5 -110 u24 -110 N/A u24.5 -115 N/A u23.5 -100 u24.5 -130 u24.5 -125 u24.5 -121 u49.5 -105  
Final
Buffalo Bills 463 Bills
-198 -115 N/A -145 N/A -120 N/A -200 -167 -142  
New England Patriots 464 Patriots
+164 -105 N/A +114 N/A -100 N/A +140 +135 +120  
Final
Buffalo Bills 463 Bills
-4.5 -110 N/A N/A +0.5 -145 N/A -1.5 +120 +0.5 -140 -0.5 even N/A -2.5 -110  
New England Patriots 464 Patriots
+4.5 -110 N/A N/A -0.5 +114 N/A +1.5 -148 -0.5 +110 +0.5 -140 N/A +2.5 -110  
Final
Buffalo Bills 463 Bills
o46.5 -110 o14 -110 N/A o14.5 -105 N/A o16.5 -118 o15.5 -120 o14.5 -110 N/A o49.5 -115  
New England Patriots 464 Patriots
u46.5 -110 u14 -110 N/A u14.5 -125 N/A u16.5 -112 u15.5 -110 u14.5 -130 N/A u49.5 -105  
Final
Buffalo Bills 463 Bills
-198 -125 N/A -115 N/A -120 N/A -135 N/A -142  
New England Patriots 464 Patriots
+164 +105 N/A -115 N/A -102 N/A even N/A +120  
Final
Buffalo Bills 463 Bills
-4.5 -110 N/A N/A -0.5 +114 N/A -1.5 +136 -0.5 -120 -2.5 -115 N/A -2.5 -110  
New England Patriots 464 Patriots
+4.5 -110 N/A N/A +0.5 -145 N/A +1.5 -174 +0.5 -110 +2.5 -120 N/A +2.5 -110  
Final
Buffalo Bills 463 Bills
o46.5 -110 o10 -110 N/A o9.5 -140 N/A o14.5 +540 o9.5 -140 o10.5 +115 N/A o49.5 -115  
New England Patriots 464 Patriots
u46.5 -110 u10 -110 N/A u9.5 +110 N/A u14.5 -1100 u9.5 +110 u10.5 -170 N/A u49.5 -105  
Final
Buffalo Bills 463 Bills
-198 -120 N/A -135 N/A -115 N/A -220 N/A -142  
New England Patriots 464 Patriots
+164 even N/A +105 N/A -105 N/A +140 N/A +120  
Final
Buffalo Bills 463 Bills
-4.5 -110 -0.5 +120 N/A -0.5 -105 N/A -1.5 +130 -0.5 -105 -0.5 -120 N/A -2.5 -110  
New England Patriots 464 Patriots
+4.5 -110 +0.5 -140 N/A +0.5 -125 N/A +1.5 -162 +0.5 -125 +0.5 -110 N/A +2.5 -110  
Final
Buffalo Bills 463 Bills
o46.5 -110 o14 -110 N/A o13.5 -125 N/A o13.5 -116 o13.5 -120 o14.5 even N/A o49.5 -115  
New England Patriots 464 Patriots
u46.5 -110 u14 -110 N/A u13.5 -105 N/A u13.5 -106 u13.5 -110 u14.5 -145 N/A u49.5 -105  
Final
Buffalo Bills 463 Bills
-198 -115 N/A -140 N/A -115 N/A -160 N/A -142  
New England Patriots 464 Patriots
+164 -105 N/A +110 N/A -104 N/A +105 N/A +120  

The Bills will take on the Patriots in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Gillette Stadium in Foxborough, Mass. The game will be broadcast live on CBS. Here's everything you need to know about Bills vs. Patriots odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -1 point favorite over Patriots. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 4/2/26

bet365
Bet $10, Get $365 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Click to Apply Code!
Deposit required. Paid in Bonus Bets. Bonus Bets wager excluded from returns. New customers only. T&Cs, time limits, and exclusions apply. Not available in Illinois.

New England Patriots vs. Buffalo Bills Prediction

The Patriots come in at 4th in Action Network's luck rankings, and the Bills come in at 11th. This indicates that some scoring regression may be inbound for this matchup. These are also two good defenses. The Patriots rank 9th in EPA/play allowed, while the Bills rank 16th.

Both units are strong defending against the pass, as the Bills and Patriots are both top 10 in EPA/pass attempt allowed. I expect a low-scoring affair in this AFC East matchup.

New England Patriots vs. Buffalo Bills Prediction: Buffalo Bills @ New England Patriots u50.5 (-110)

(Pick from Dylan Wilkerson)

Looking for more predictions? Check out our free NFL picks and our premium subscription for the best picks!

Google Preferred Source

What Time is the New England Patriots vs. Buffalo Bills Game?

The New England Patriots vs. Buffalo Bills game is at 1:00 PM ET on Sunday, December 14th.

Where is the New England Patriots vs. Buffalo Bills Game Being Played?

This game will be played at Gillette Stadium in Foxborough, Mass.

How Can I Watch New England Patriots vs. Buffalo Bills?

You can watch New England Patriots vs. Buffalo Bills on CBS.

Can the Patriots Beat the Bills?

Of course! this game is close, anything can happen in the NFL!

Featured News

Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
•