NFL Odds Week 1: Rams vs Seahawks Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

2 minute read

NFL odds for Week 1 are on the board and receiving plenty of attention as the regular season gets ready to kick off. The Rams and Seahawks meet at Lumen Field in Seattle on Sunday, September 10 at 4:25 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for the Week 1 game between the Rams and Seahawks: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Los Angeles Rams vs Seattle Seahawks Odds

• Opening point spread: Seahawks -5.5
• Opening moneyline: Seahawks -210/Rams +175
• Opening total: Over/Under 46 points scored
• Time: 4:25 p.m. ET Sunday, Sept. 10 (FOX)

UPDATE 3:30 P.M. ET SUNDAY: Seattle opened -5.5 at BetMGM and toggled between -5.5/-5/-4.5 from late August to early September. On Thursday, the line fell to Seahawks -4, and it's now at Seattle -4.5.

UPDATE 5 P.M. ET FRIDAY: On Wednesday, Rams wideout Cooper Kupp (hamstring) was ruled out for Week 1. But that was already baked into BetMGM's NFL Week 1 odds cake, with the Seahawks sticking at -5.5.

That's where BetMGM opened this game back in May. On Aug. 21, the line dipped to Seattle -4.5, but followed with a couple trips back to -5.5, the latest coming on Sunday.

However, late Thursday afternoon, BetMGM dropped Seattle straight to -4. The Seahawks are now -4.5 (-105), while taking 74% of spread bets/70% of spread dollars.

The total opened at 46.5, peaked at 47.5 a couple times and receded to 46 by Sunday. The Under is taking 59% of bets/52% of money.

UPDATE 1:30 P.M. ET MONDAY, AUG. 28: Seattle won its final two regular-season games to land a Wild Card bid last season. The Seahawks then gave NFC West rival San Francisco a challenge for a half, leading 17-16 at the break.

But Seattle got rolled in the second half, losing 41-23 as a 10-point road pup to finish 9-9 SU/7-11 ATS.

After winning the Super Bowl in the 2021-22 season, Los Angeles had an injury-plagued 5-12 SU/7-9-1 ATS campaign. QB Matt Stafford (concussion/neck issues) missed the final seven games, though the Rams were already in a 3-7 SU hole at that point.

Wideout Cooper Kupp (ankle) sat out the second half of the season.

All that noted, this line is down a point to Seahawks -4.5 at The SuperBook. The latest move from Seattle -5 to -4.5 came on Aug. 23. The total peaked at 47.5 Aug. 2 and regressed to 46.5 Aug. 24. While The SuperBook's spread/total opened back on May 11, the moneyline just opened today, hence no movement so far.

Where to place a bet this NFL Season?

• Use our exclusive BetMGM Bonus Code VIBONUS1600 to unlock BetMGM's welcome offer for new sportsbook users!
• Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
• Sports betting is live in North Carolina! Check out our list of North Carolina Sportsbooks and get ready for the NFL season.
• Our DraftKings Promo Code earns users $150 in bonus bets when you bet $5. Sign up today!

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson