NFL Odds Week 10: Lines, Spreads, Betting Trends For All 14 Games

Patrick Everson Sports Betting Expert

16 minute read

2025 NFL Odds Week 10

NFL odds for Week 10, much like Week 9, have a no-doubt marquee matchup, this time among two of the NFC's best.

Philadelphia Eagles vs. Green Bay Packers highlights NFL Week 10 odds, on Monday Night Football. Other notable contests: Los Angeles Rams vs. San Francisco 49ers and New England Patriots vs. Tampa Bay Buccaneers.

Here’s everything you need to know about the NFL odds Week 10 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on Week 10 NFL odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Peter Casey/Imagn Images)

NFL Odds for Every Game of NFL Week 10

Las Vegas Raiders vs. Denver Broncos Odds

• Opening point spread: Broncos -10
• Opening moneyline: Broncos TBA/Raiders TBA
• Opening total: Over/Under 42.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

MIDWEEK UPDATE: Denver hit Borgata Sports' NFL odds Week 10 market as 10-point home chalk Sunday evening. As of 4 p.m. ET Wednesday afternoon, the Broncos are down to -9.

"We saw some respected money take the 10 with Las Vegas at opening," Borgata sportsbook director Tom Gable said. "Denver was fortunate to escape with a win [at Houston] at the last minute, and the Raiders had an opportunity in overtime to win it against Jacksonville."

In case you missed it, more below on both team's Week 9 outcomes.

OPENING ODDS UPDATE: Denver (7-2 SU/4-5 ATS) didn't post the most riveting win in Week 9, but you can't argue much with a team on a 6-0 SU streak. The Broncos were 2-point underdogs at Houston and won 18-15 on a final-seconds field goal.

Denver benefited from Houston QB C.J. Stroud exiting with a concussion in the second quarter.

Las Vegas (2-6 SU/3-5 ATS) has dropped six of its last seven games (2-5 ATS). In Week 9, the Raiders got a touchdown with 1:52 remaining to take a 23-20 lead over Jacksonville. But Vegas then gave up a field goal and got pushed to overtime tied at 23.

The Jags then got a TD to go up 30-23, and the Raiders responded with their own TD with just 16 seconds left in OT. But Pete Carroll's troops went for 2 and the win, and didn't get it, losing 30-29 while covering as a 1.5-point home 'dog.

The Raiders-Broncos line made a relatively quick move Sunday night in The SuperBook's NFL odds Week 10 market.

"We took some respected action on the Raiders +10 that bumped us down to +9.5," SuperBook risk manager Casey Degnon said. "I think the spread will see some good two-way action.

"But ultimately, between parlays and teasers, I expect that we will be rooting for the Raiders to pull the upset on TNF."

Atlanta Falcons vs. Indianapolis Colts Odds

• Opening point spread: Colts -6.5
• Opening moneyline: Colts TBA/Falcons TBA
• Opening total: Over/Under 48.5 points scored
• Time: 9:30 a.m. ET Sunday (NFL Network)

MIDWEEK UPDATE: Indianapolis made the biggest trade-deadline splash Tuesday, acquiring star cornerback Sauce Gardner in a deal with the New York Jets. Shortly after news of the deal broke, the Colts moved from -5.5 to -6 vs. the Falcons in Borgata Sports' NFL Week 10 odds.

Early Wednesday afternoon, Indy went to -6.5, matching the Sunday night opening line.

"The Colts are obviously in win-now mode, after trading for Sauce Gardner and giving up two first round picks for him," Borgata sportsbook director Tom Gable said. "But they need to take better care of the football on the offensive side than they did on Sunday against Pittsburgh.

"Most bettors will probably be counting on a bounce-back spot here for Indy."

Indianapolis had six turnovers in its Week 9 road loss.

OPENING ODDS UPDATE: Indianapolis (7-2 SU/6-3 ATS) finally got knocked off its perch as the NFL team with the best record. Daniel Jones had five turnovers – three interceptions, two lost fumbles – and the Colts tumbled 27-20 giving 3 points at Pittsburgh.

Atlanta (3-5 SU and ATS) gave streaking New England all it could handle in Week 9. Drake London got his third touchdown catch of the day to pull Atlanta within 24-23 with 4:40 remaining. But the Falcons missed the extra point, losing by that same score as 5.5-point road 'dogs.

Falcons-Colts has both teams making the long flight to Berlin, Germany, for a neutral-site game. Indy opened -6.5 in The SuperBook's NFL Week 10 odds.

"Last week, we saw some sharp money on the lookahead line Falcons +7," SuperBook risk manager Casey Degnon said. "We opened 6.5 today, and I don't think the line will go back up.

"But once again, counting parlays and teasers, we will almost certainly be rooting for the Falcons to pull off the upset in Germany."

Check out VegasInsider's NFL Week 10 Best Bets!

New England Patriots vs. Tampa Bay Buccaneers Odds

• Opening point spread: Buccaneers -2.5
• Opening moneyline: Buccaneers TBA/Patriots TBA
• Opening total: Over/Under 48.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

MIDWEEK UPDATE: Tampa Bay is painted to -2.5 at Borgata Sports, with no spread movement so far this week.

"The Patriots are still sitting atop the AFC East, but they know they have the Bills chasing them," Borgata sportsbook director Tom Gable said. "Tampa, meanwhile, had a much needed bye week, with so many injuries to deal with.

"The early-season MVP buzz around Baker Mayfield has dissipated with some recent performances. But this is still a very good football team and is rightfully favored in this spot."

OPENING ODDS UPDATE: New England (7-2 SU/6-3 ATS) barely got off the hook in Week 9, while running its SU win streak to six. The Patriots closed as 5.5-point home favorites and edged Atlanta 24-23.

The winning margin came on a missed extra point after the Falcons got a TD with 4:40 remaining.

Tampa Bay (6-2 SU/5-3 ATS) is coming off its bye week. In Week 8, the Buccaneers dumped New Orleans 23-3 laying 3.5 points on the road.

The SuperBook opened Pats-Bucs at Tampa -2.5 in Week 10 NFL odds, with no movement in the early going.

"This is a sneaky good game in the early slate on Sunday," SuperBook risk manager Casey Degnon said. "I think the public will be split on this one, and I expect both sides will take money throughout the week.

"With the Bucs' high-powered offense and Drake Maye playing like a franchise QB, I think we'll need the Under here."

Baltimore Ravens vs. Minnesota Vikings Odds

• Opening point spread: Ravens -3.5
• Opening moneyline: Ravens TBA/Vikings TBA
• Opening total: Over/Under 47 points scored
• Time: 1 p.m. ET Sunday (FOX)

MIDWEEK UPDATE: As of 4:30 p.m. ET Wednesday, Baltimore is 4-point chalk in Borgata Sports' Week 10 NFL odds, up a tick from the -3.5 opener.

"The Vikings surprised a lot of bettors with their outright win against the Lions, in J.J. McCarthy’s first game back," Borgata sportsbook director Tom Gable said. "It doesn’t get any easier here, as they face Lamar Jackson and the Ravens. But at least the Vikings have home field.

"It’s been early Ravens money, though. The Ravens have a nice rest advantage, as they last played last Thursday night."

The Ravens-Vikes total is now out to 49.5, from a 47.5 opener.

OPENING ODDS UPDATE: Baltimore (3-5 SU and ATS) finally got Lamar Jackson back under center in Week 9, and the result was as expected. The Ravens were 7.5-point Thursday night road favorites and rolled over Miami 28-6.

Minnesota (4-4 SU and ATS) got J.J. McCarthy back under center and evened its record with a big Week 9 upset. The Vikings went to Detroit as 9.5-point pups, led much of the game and held on for a 27-24 victory. Minnesota ended a 1-3 SU and ATS skid.

Baltimore opened -3.5 vs. Minnesota in The SuperBook's NFL Week 10 odds. There was no early movement Sunday night.

Get your lineup in order with VI's NFL Week 10 Fantasy Preview!

Buffalo Bills vs. Miami Dolphins Odds

• Opening point spread: Bills -9.5
• Opening moneyline: Bills TBA/Dolphins TBA
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Buffalo (6-2 SU/4-4 ATS) closed as a rare home underdog in Week 9, getting 2.5 points vs. Kansas City. But the Bills notched an impressive 28-21 victory over their AFC archrival. Josh Allen & Co. are on a modest two-game SU and ATS upswing.

Miami (2-7 SU/4-5 ATS) gets a mini-bye, having played in the Week 9 Thursday night game. But it wasn't a good outing for the struggling Dolphins, who lost 28-6 catching 7.5 points at home vs. Baltimore.

The SuperBook opened Bills-Dolphins at Buffalo -9.5, with no early movement Sunday night. These two teams met in the Week 3 Thursday night game and were tied at 21 early in the fourth quarter.

Buffalo then pulled away for a 31-21 win, but Miami covered as an 11.5-point road 'dog.

New York Giants vs. Chicago Bears Odds

• Opening point spread: Bears -3.5
• Opening moneyline: Bears TBA/Giants TBA
• Opening total: Over/Under 48.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Chicago (5-3 SU and ATS) blew a big late lead at Cincinnati, but still escaped with a Week 9 victory. The Bears led 41-27 with 4:53 remaining, then gave up two TDs to fall behind 42-41 with 54 seconds left.

But Caleb Williams hit Colston Loveland on a 58-yard catch-and-run touchdown to give Chicago a whirlwind 47-42 victory as 3-point road chalk.

New York (2-7 SU/4-5 ATS) got an early TD to go up 7-0, but wouldn't lead again against visiting San Francisco. The Giants gave up 27 of the next 30 points en route to a 34-24 loss getting 2.5 points.

Giants-Bears opened at Chicago -3.5 in The SuperBook's NFL odds Week 10 market. There was no early movement Sunday night.

Jacksonville Jaguars vs. Houston Texans Odds

• Opening point spread: Texans -1
• Opening moneyline: Texans TBA/Jaguars TBA
• Opening total: Over/Under 39.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Houston (3-5 SU and ATS) looked solid in Week 8 against San Francisco, then regressed in Week 9 as 2-point home chalk vs. Denver. Part of that was due to losing quarterback C.J. Stroud to a concussion in the second quarter.

The Texans put up just five field goals – no touchdowns – and lost 18-15 on a final-seconds field goal.

Jacksonville (5-3 SU and ATS) came out on top in a back-and-forth battle with Las Vegas. The Jaguars got a late field goal to forge a 23-23 tie and force overtime.

In the extra frame, the Jags got a touchdown to go up 30-23, then gave up a TD with just 16 seconds left. But Jacksonville turned back a 2-point attempt to seal a 30-29 victory as 1.5-point road favorites.

Jags-Texans is practically a coin toss, with Houston opening -1 in The SuperBook's Week 10 NFL odds. The spread was stable Sunday night, while the total dropped from 39.5 to 38.5.

Cleveland Browns vs. New York Jets Odds

• Opening point spread: Jets -2
• Opening moneyline: Jets TBA/Browns TBA
• Opening total: Over/Under 38.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New York (1-7 SU/3-5 ATS) is coming off a bye, after a big comeback to get its first win of the season. The Jets trailed at Cincinnati 38-24 with 10:21 remaining, but rallied for a 39-38 victory catching 5.5 points.

Cleveland (2-6 SU/3-5 ATS) also had a bye in Week 9. The Browns tumbled at New England 32-13 as 7-point Week 8 underdogs.

Week 10 marks a rare occurrence of the Jets being favored, with The SuperBook opening New York -2. The total was stable Sunday night, and the total dropped from 38.5 to 37.5.

New Orleans Saints vs. Carolina Panthers Odds

• Opening point spread: Panthers -4.5
• Opening moneyline: Panthers TBA/Saints TBA
• Opening total: Over/Under 40.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Carolina (5-4 SU/6-3 ATS) notched the upset of the week with a shocking victory at Green Bay. The Panthers closed as 12.5-point underdogs and bagged a 16-13 victory on Ryan Fitzgerald's 49-yard field goal as time expired.

New Orleans (1-8 SU/2-7 ATS) was a double-digit underdog at the L.A. Rams, and played like it. The Saints got rolled 34-10 getting 14.5 points, their fourth consecutive SU and ATS setback.

The SuperBook opened Carolina -4.5 Sunday night in the NFL odds Week 10 market. There's been no early movement.

Arizona Cardinals vs. Seattle Seahawks Odds

• Opening point spread: Seahawks -6
• Opening moneyline: Seahawks TBA/Cardinals TBA
• Opening total: Over/Under 44 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

EARLY WEEK UPDATE: Arizona (3-5 SU/5-3 ATS) was still without Kyler Murray (foot) in the Week 9 Monday night game. But Jacoby Brissett was on point, helping the Cardinals to a 27-17 victory as 3.5-point road 'dogs vs. Dallas.

Brissett threw for two TDs and ran for another as Arizona ended a five-game SU skid while covering for the third straight week.

The SuperBook opened Cards-Seahawks at Seattle -6, ahead of Seattle's blowout Sunday night win at Washington. Monday morning, Cards-Seahawks moved to Seattle -7, and the matchup then came off the board Monday night, during the Cards-Cowboys game.

The SuperBook will put Cardinals-Seahawks back up Tuesday morning.

OPENING ODDS UPDATE: Seattle (6-2 SU and ATS) looked every bit an NFC playoff contender in the Week 9 Sunday nighter. Sam Darnold went 16-for-16 with four TD passes in the first half, and the Seahawks blasted Washington 38-14 as 2.5-point road favorites.

Arizona (2-5 SU and ATS) still has Week 9 work ahead of it, hosting Dallas on Monday night.

Cards-Seahawks opened at Seattle -6 in The SuperBook's Week 10 NFL odds. Once the Seahawks-Commanders game kicked off, Cards-Seahawks was taken off the board, and it will go back up Monday morning.

Los Angeles Rams vs. San Francisco 49ers Odds

• Opening point spread: Rams -3.5
• Opening moneyline: Rams TBA/49ers TBA
• Opening total: Over/Under 49 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

MIDWEEK UPDATE: Los Angeles is out to -4 from -3 opener in Borgata Sports' NFL odds Week 10 market. On Wednesday morning, the Rams moved from -3.5 to -4, and the line is still -4 at 4:30 p.m. ET Wednesday.

"Most of the early money is coming in on L.A.," Borgata sportsbook director Tom Gable said. "The Rams are back to looking like one of the best teams in the NFC. In fact, I currently have them power-rated the highest of any team in the NFC.

"But there is still a lot to be decided in their own division, with an upstart Seattle team and their opponent in this game, the Niners."

Borgata's total is up to 49.5 from a 48.5 opener.

OPENING ODDS UPDATE: Los Angeles (6-2 SU and ATS) was the biggest favorite of Week 9 and had no trouble covering a big number. The Rams coasted to a 34-10 win over New Orleans laying 14.5 points at home.

San Francisco (6-3 SU and ATS) continues finding ways to win with its depleted lineup. In Week 9, the 49ers spotted the New York Giants an early touchdown. Then Mac Jones & Co. scored 27 of the next 30 points on the way to a 34-24 victory laying 2.5 points on the road.

The SuperBook opened Rams-Niners at L.A. -3.5, with no movement Sunday night in NFL Week 10 odds. The total, however, saw a nudge from 49 to 49.5.

"This is a game where I think the public will line up on the Rams, as well as the Over," SuperBook risk manager Casey Degnon said. "Aside from the spread, the Rams will be a popular moneyline play for parlays.

"So I'd be surprised if we're not rooting for the Niners to not only cover, but also win as a home underdog next week."

It wouldn't be first time that's happened this season. In Week 5, injury-depleted San Fran was an 8-point road pup and upset L.A. 26-23 in overtime.

Detroit Lions vs. Washington Commanders Odds

• Opening point spread: Lions -3.5
• Opening moneyline: Lions TBA/Commanders TBA
• Opening total: Over/Under 51.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

MIDWEEK UPDATE: With no Jayden Daniels for the Commanders, this line went straight from Lions -3 to -7.5 Sunday night at Borgata Sports. It got as high as Lions -9.5 by Tuesday afternoon. Wednesday afternoon finally saw some regression, to Detroit -9/-8.5/-8.

"The Commanders season is all but over, after the injury to Daniels on and with their current [3-5] record," Borgata sportsbook director Tom Gable said. "There were a lot of high hopes around this team coming into the season if they could build on the success they had last year in the playoffs."

"Their opponents in this one, the Lions, also had renewed hopes after bowing out of the playoffs early last season. But things haven’t gone exactly to plan in Detroit either. The Lions are still in the midst of a division crown chase with a flawed Packers team, so anything is possible."

Borgata initially moved the total from 51.5 to 50.5 on the Daniels injury, and it's been at 49.5 since Monday evening.

EARLY WEEK UPDATE: This line saw a huge adjustment in the wake of Jayden Daniels' injury in the Commanders' blowout Sunday night loss to Seattle. The SuperBook reopened the spread Monday morning at Lions -9.

That up 5.5 points from Sunday evening's Detroit -3.5 line, before Washington's loss and Daniels' injury vs. Seattle.

OPENING ODDS UPDATE: Detroit (5-3 SU and ATS) was a huge public darling in Week 9, per usual. But it didn't work out for the betting masses, as the Lions tumbled to Minnesota 27-24 as 9.5-point home favorites.

Still, over the past three years – since the middle of the 2022-23 season – Detroit is 42-14 SU/40-15-1 ATS.

Washington (3-5 SU and ATS) took two big losses in the Week 9 Sunday nighter, one on the scoreboard and one with an injury. The Commanders found themselves in a 28-0 second-quarter hole vs. Seattle and never recovered in a 38-14 loss getting 2.5 points at home.

Worse, in the fourth quarter, QB Jayden Daniels suffered a dislocated left elbow. Daniels' return this season is uncertain.

The SuperBook opened Detroit -3.5 vs. Washington, and the game came off the board once Seahawks-Commanders kicked off. Lions-Commanders will go back up Monday morning.

"I think the Commanders' performance will affect the betting on this one, especially with the Lions getting upset today," SuperBook risk manager Casey Degnon said before the Commanders' SNF setbacks. "If I had to guess, I'd think the underdog and Under will be our preferred side come Sunday afternoon." 

Pittsburgh Steelers vs. Los Angeles Chargers Odds

• Opening point spread: Chargers -3.5
• Opening moneyline: Chargers TBA/Steelers TBA
• Opening total: Over/Under 45.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

For more, check out VegasInsider's Steelers vs. Chargers Prediction.

OPENING ODDS UPDATE: Los Angeles (6-3 SU/5-4 ATS) got more than it bargained for as a 9.5-point favorite at Tennessee. But the Chargers got out with a 27-20 victory.

Pittsburgh (5-3 SU/4-4 ATS) ended a two-game SU and ATS hiccup with a modest Week 9 upset. The Steelers knocked off red-hot Indianapolis 27-20 catching 3 points at home.

Steelers-Chargers opened at L.A. -3.5 in The SuperBook's NFL odds Week 10 market, then dipped to -3 within 20 minutes Sunday night.

"I think we'll see split action up until kickoff. It doesn't feel like either the spread or total will get overwhelming support from the public," SuperBook risk manager Casey Degnon said. "The Chargers will be used in parlays, but not as much as some of the bigger favorites in the Week 10 slate."

Philadelphia Eagles vs. Green Bay Packers Odds

• Opening point spread: Packers -3
• Opening moneyline: Packers TBA/Eagles TBA
• Opening total: Over/Under 44.5 points scored
• Time: 8:15 p.m. ET Monday (ABC/ESPN)

MIDWEEK UPDATE: As of 5 p.m. ET Wednesday, Green Bay remains pinned to -2.5 in Borgata Sports' NFL Week 10 odds, with no spread movement this week. But there's plenty of interest in this prime-time showdown.

"It’s somewhat unusual to be in the middle of the week and have the Monday night game with the most handle written, of any game on the slate for Week 10," Borgata sportsbook director Tom Gable said. "But that’s the case here, probably helped by the fact that it is the Eagles playing in it."

Indeed, Borgata is in Atlantic City, a relative stone's throw from Philadelphia.

"Early action has been very balanced on the side," Gable said. "The Eagles are coming off a bye week and a very busy trade deadline week, in which Howie Roseman helped strengthen the secondary.

"Green Bay is coming off a head-scratching loss to the Panthers. But at least the Packers have an extra day to prepare for the defending Super Bowl champs."

Borgata's total is at 44.5 from a 45.5 opener.

OPENING ODDS UPDATE: Green Bay (5-2-1 SU/3-5 ATS) was seen as almost a sure thing in Week 9 vs. Carolina. The Packers closed as 13-point home favorites, but got stung with a 16-13 outright loss on a final-seconds field goal.

Philadelphia (6-2 SU/5-3 ATS) is coming off its bye week, after winning and cashing in the last two games. In Week 8, the Eagles dispatched the New York Giants 38-20 giving 7.5 points at home.

The SuperBook opened Eagles-Packers at Green Bay -3 and is already down to -2.5 Sunday night.

"This is another game where I think we will see somewhat equal action on the spread," SuperBook risk manager Casey Degnon said. "We might not know who we are rooting for Monday night until we actually kick off.

"Either way, it's good to see that we won't have to depend on a touchdown-plus underdog to win outright in prime time."

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson