NFL Odds Week 12: 49ers vs Seahawks Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

The Thanksgiving Day NFL slate concludes with a heavyweight NFC West battle between the San Francisco 49ers and Seattle Seahawks. The Week 12 betting odds see Seattle as a seven-point underdog after losing a heartbreaker to the Rams last week. Coverage begins from Lumen Field in Seattle on Thursday, November 23 at 8:20 p.m. ET on NBC.

Here's everything you need to know about the NFL odds for Week 12: 49ers vs. Seahawks lines, spreads, betting trends and more.

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San Francisco 49ers vs Seattle Seahawks Odds

• Opening point spread: 49ers -7
• Opening moneyline: 49ers -330/Seahawks +260
• Opening total: Over/Under 43.5 points scored
• Time: 8:20 p.m. ET Thursday (NBC)

UPDATE 7:30 P.M. ET THURSDAY: With kickoff 45 minutes out, the 49ers are 7-point favorites in DraftKings' NFL odds Week 12 market. San Fran opened -6 Sunday night and quickly advanced to -7, then spent most of Monday/Tuesday at various iterations of -6.5.

The number got to Niners -7.5 for a couple hours Wednesday. It's been various juice at -7 all day today, with ticket count 3/1 and money 4/1 on San Francisco. And moneyline splits are even more tilted toward the Niners, even though bettors are laying -360.

DK opened the total at 43.5, bottomed out within an hour at 42.5 Sunday night, then steadily rebounded to 44 by Wednesday. It dipped to 43.5 this morning, then a couple times went to 43, where it sits now.

The Over is seeing 62% of tickets, while 55% of cash is on the Under.

UPDATE 4 P.M. ET WEDNESDAY: TwinSpires has the Turkey Day nightcap at Niners -7, matching Sunday's opening number. San Fran is drawing 70% of early spread tickets/77% of early spread money.

"It's all 49ers – singles/parlays/teasers. Bettors can't get enough of San Francisco in this spot, vs. the Seahawks with a banged-up QB."

Seattle QB Geno Smith suffered a right-arm injury in the Week 11 road loss to the L.A. Rams. It appears he'll play, but he could be limited.

TwinSpires' total inched down from 43.5 to 43, with 61% of tickets on the Over/54% of money on the Under.

UPDATE 10 P.M. ET SUNDAY: San Francisco (7-3 SU/5-5 ATS) coasted to a 27-14 victory over Tampa Bay in Week 11. However, the Niners were just shy of covering the 13.5-point spread, falling to 1-4 ATS in their last five games.

Seattle (6-4 SU/5-5 ATS) dropped two of its last three games, after a 5-2 SU start. In Week 11, the Seahawks got out to a 13-0 first-half lead against the L.A. Rams. But Seattle slowed from there and lost 17-16 getting 2.5 points on the road.

The 49ers-Seahawks line has already seen a lot of movement tonight. That's because Seattle QB Geno Smith injured his elbow against the Rams, but ultimately returned to play.

"We have been all over the place on this line, based on the health of Geno Smith. We were as high as 49ers -9.5 at one point, then Smith came back into today's loss to the Rams, and we were as low as 49ers -6," Michaelson said. "Right now, we're sitting at 7, but it'll be interesting to see which way the market goes with this one, based on Smith's health.

"The one thing we know for sure is that every parlay will be tied to San Francisco. The way the 49ers have played the last two weeks will mean the public is back in on them."

Further, in the Thanksgiving Day games, Michaelson expects the three-leg moneyline parlay of Lions/Cowboys/49ers to be very popular.

"We'll be rooting for Seattle to spring the upset, for sure," he said.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 12 Report containing spreads, lines, and trends for every NFL matchup.

49ers vs Seahawks Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Check back soon for picks!

Pick: TBD

For more NFL picks, check out Action Network's NFL Week 12: How to Bet Every Game & Every Team.

The One Stat to Know About 49ers vs Seahawks

Action Network NFL researcher Evan Abrams offers his top betting stat:

Check back soon for betting stats!

For more NFL betting stats, check out Action Network's NFL Week 12 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson