NFL Odds Week 15: 49ers vs Cardinals Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

2 minute read

Week 15 of the NFL season continues with what's expected to be a lopsided NFC West tilt between the San Francisco 49ers and Arizona Cardinals. The betting odds see Arizona as a 13.5-point underdog coming off an impressive win over the Steelers in their latest outing. Coverage begins from State Farm Stadium in Glendale, Arizona on Sunday, December 17 at 4:05 p.m. ET on CBS.

Here's everything you need to know about the NFL odds for Week 15: 49ers vs. Cardinals lines, spreads, betting trends and more.

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San Francisco 49ers vs Arizona Cardinals Odds

• Opening point spread: 49ers -14
• Opening moneyline: 49ers -1200/Cardinals +700
• Opening total: Over/Under 46.5 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

UPDATE 3:45 P.M. ET SUNDAY: BetMGM is down to 49ers -11.5 minutes before kickoff and actually got to -11 early this afternoon. That's after opening San Fran -14 and steadily dipping throughout the week.

Still, spread tickets and money are in the 2/1 range on the Niners. And no doubt, countless moneyline parlays and teasers include San Francisco.

The total is down a tick from Friday's 48.5 high point at BetMGM (see below update). But tickets are running 2/1 and money 3/1 on the Over.

UPDATE 11 P.M. ET FRIDAY: The Niners opened as 14-point road favorites Sunday at BetMGM and quickly adjusted to -13.5. On Wednesday, the number slipped to -12.5, and it's now at -12.5 (-105).

San Fran is seeing 62% of early spread bets/57% of early spread dollars.

The total opened at 46.5 and made its way to 48.5 by this morning, with a couple of stops along the way. It's two-way play, with 53% of bets on the Over/53% of money on the Under.

UPDATE 10:30 P.M. ET SUNDAY: San Francisco (10-3 SU/7-6 ATS) is on a five-game SU roll (3-2 ATS) heading into Week 15. The Niners dispatched Seattle 28-16, though they failed to cash as hefty 14.5-point favorites.

Arizona (3-10 SU/7-6 ATS) is coming off its bye week. In Week 13, the Cards rolled over Pittsburgh 24-10 as 6-point road pups.

The SuperBook opened 49ers-Cards at San Fran -14 tonight and backed up to -13.5. The total is stable at 46.5 in the NFL odds Week 15 market.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 15 Report containing spreads, lines, and trends for every NFL matchup.

49ers vs Cardinals Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Did you see the scores of these games the past three meetings? 38-10, 38-13 and 35-16 sort of speaks for itself. The 49ers' offense has been unstoppable, and it's not like the Cardinals are stopping anyone anyway. Arizona's offense has had its moments under Drew Petzing, but the defense has really never had the juice this season and ranks bottom three in most metrics.

The 49ers have scored at least 27 points in every win this season, and the Cardinals have already allowed five opponents to top this total this season. It's telling that Christian McCaffrey is a ridiculous -450 to score an Anytime TD this week. The 49ers are going to score, and score often. Just lean in.

Pick: 49ers TT Over 30.5

For more NFL picks, check out Action Network's NFL Week 15: How to Bet Every Game & Every Team.

The One Stat to Know About 49ers vs Cardinals

Action Network NFL researcher Evan Abrams offers his top betting stat:

The Cardinals are one of two teams to be listed as underdogs in all of their games so far this season – with the Panthers.

For more NFL betting stats, check out Action Network's NFL Week 15 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson