NFL Odds Week 15: Cowboys vs Bills Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

Week 15 of the NFL season continues with a heavyweight non-conference showdown between the Dallas Cowboys and Buffalo Bills. The betting odds see Buffalo as a 1.5-point favorite despite trailing Dallas by three games in the overall standings. Coverage begins from Highmark Stadium in Orchard Park on Sunday, December 17 at 4:25 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for Week 15: Cowboys vs. Bills lines, spreads, betting trends and more.

ESPN BET Sportsbook is here! Use our promo code to join and claim your bonus offer!

Dallas Cowboys vs Buffalo Bills Odds

• Opening point spread: Bills -2
• Opening moneyline: Bills -130/Cowboys +110
• Opening total: Over/Under 48.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

UPDATE 4 P.M. ET SUNDAY: Inside 30 minutes before kickoff, BetMGM has Buffalo as 2-point chalk. The Bills opened -1.5 and peaked at -2.5 a couple times early in the week, then spent the past few days toggling between -2/-1.5.

Buffalo is taking 56% of spread bets/64% of spread dollars. On the moneyline, it's 66% bets on Dallas and 57% money on Buffalo.

The total opened at 48.5, peaked at 50.5 Tuesday, then went to 50 Friday and 49.5 Saturday. This morning brought moves to 49 and 48.5, and it's now at 49 again. The Over is landing 52% of tickets/67% of money.

UPDATE 5 P.M. ET WEDNESDAY: Buffalo went from -2 to -2.5 and back to -2, then this afternoon dipped to -1.5 in TwinSpires' NFL odds Week 15 market. The Cowboys are getting 54% of early spread tickets, while 58% of early spread money is on the Bills.

"Really good two-way action so far this week," Lucas said.

The total is up a point from 40.5 to 50.5, with 66% of tickets/77% of money on the Over.

"The public is expecting this to be a shootout," Lucas said.

UPDATE 11 P.M. ET SUNDAY: Dallas (10-3 SU/9-4 ATS) notched a statement win over Philadelphia in Week 14. The Cowboys rolled 33-13 as 3.5-point home favorites to tie the Eagles atop the NFC East.

Dak Prescott and Co. are on a 5-0 SU/4-1 ATS upswing.

Buffalo had a must-win game in a tough-to-win place in Week 14. But the Bills (7-6 SU/5-7-1 ATS) jumped out a 14-0 second-quarter lead at Kansas City and held on for a 20-17 victory. Buffalo, a 1.5-point underdog, got the go-ahead field goal with 1:54 remaining.

The SuperBook opened Buffalo 2-point chalk tonight in its NFL Week 15 odds market. About 45 minutes later, the Bills advanced to -2.5. The total rose a tick, too, from 48.5 to 49.

But once Eagles-Cowboys kicked off, Cowboys-Bills was taken off the board. Cowboys-Bills will go back up Monday morning.

"You can see why the Bills closed as close as they did against K.C. today. They're still one of the highest power-rated teams in the league, despite their record. And this line reflects a pretty even playing field," Michaelson said.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 15 Report containing spreads, lines, and trends for every NFL matchup.

Cowboys vs Bills Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

The Cowboys made a handful of key free agent signings this offseason that had me excited about Dallas coming into the season. One of those key additions was CB Stephon Gilmore, who was a huge difference maker in last week's win over Philadelphia. Brandin Cooks was another supposedly big addition, but an early injury has limited his season impact.

Cooks exploded with 9/173/1 against the Giants a month ago and is finally looking healthy. He's averaging 4.4 catches for 73.8 yards over the past five games with increasing snap counts that have him on the field most of the game. He's had at least 37 yards in all five, so this line is pricing him at his floor. Buffalo ranks last against WR2s by DVOA and near the bottom defending deep passes.

The Bills are sure to give heavy coverage to CeeDee Lamb, and Cooks will get his chances. Could this be the game where the signing pays off? You can play a SGP of 70 yards and a score at +750 (DraftKings), something he's done twice in the past five games, and hope for a long score.

Pick: Brandin Cooks Over 38.5 Receiving Yards (-115)

For more NFL picks, check out Action Network's NFL Week 15: How to Bet Every Game & Every Team.

The One Stat to Know About Cowboys vs Bills

Action Network NFL researcher Evan Abrams offers his top betting stat:

Bills: Josh Allen has thrown an INT in nine straight games – the first time he’s done that in the regular season in his career.

For more NFL betting stats, check out Action Network's NFL Week 15 Betting Trends, Stats, Notes.

ESPN BET Sportsbook is almost here - use our promo code to join and claim your bonus offer!

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson