NFL Odds Week 18: Rams vs 49ers Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

Week 18 of the NFL season continues with a matchup between a pair of NFC West teams that have already clinched playoff spots as the Los Angeles Rams take on the San Francisco 49ers. The betting odds see San Francisco as a 4.5-point home favorite with a win earning them the No. 1 seed in the conference. Coverage begins from Levi's Stadium in Santa Clara on Sunday, January 7 at 4:25 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for Week 18: Rams vs 49ers lines, spreads, betting trends and more.

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Los Angeles Rams vs San Francisco 49ers Odds

• Opening point spread: 49ers -2.5
• Opening moneyline: 49ers -200/Rams +170
• Opening total: Over/Under 43.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

UPDATE 4 P.M. ET SUNDAY: San Fran is 5.5-point home chalk minutes before kickoff, after opening -2.5 last Sunday at DraftKings. Spread ticket count is dead even, and 54% of money is on the Niners.

DK's total is at 40, having steadily dropped throughout the week from a 44 opener. The Over is taking 65% of bets, while 53% of cash is on the Under.

UPDATE 2:30 P.M. ET FRIDAY: The 49ers will surely rest a host of players, but remain favorites on BetMGM's NFL Week 18 odds board. San Fran opened -3, got to -4.5 Monday, then Tuesday receded to -3 again.

San Francisco climbed back to -4.5 Wednesday and has been stable at -4 since mid-afternoon Wednesday. The Niners are netting 60% of early spread bets/66% of early spread money.

BetMGM opened the total at 42.5 and on Wednesday dropped to 41.5/41. It's still at 41, with bet count almost dead even and 80% of money on the Under.

UPDATE 2:30 P.M. ET FRIDAY: The 49ers will surely rest a host of players, but remain favorites on BetMGM's NFL Week 18 odds board. San Fran opened -3, got to -4.5 Monday, then Tuesday receded to -3 again.

San Francisco climbed back to -4.5 Wednesday and has been stable at -4 since mid-afternoon Wednesday. The Niners are netting 60% of early spread bets/66% of early spread money.

BetMGM opened the total at 42.5 and on Wednesday dropped to 41.5/41. It's still at 41, with bet count almost dead even and 80% of money on the Under.

UPDATE 10 P.M. ET SUNDAY: San Francisco (12-4 SU/9-7 ATS) locked up the No. 1 seed in the NFC with a Week 17 win at Washington. The Niners took a while to get going, allowing the Commanders to tie the game at 10 in the second quarter.

But San Fran went on to win 27-10 and cash as 14-point chalk.

Los Angeles (9-7 SU/9-6-1 ATS) has won three in a row and six of seven (5-2 ATS) to move into No. 6 in the NFC. In Week 17, the Rams squeaked by the New York Giants 26-25 laying 6.5 points on the road.

San Francisco has nothing to play for this week, and L.A. is locked into a Wild Card slot. The Niners opened -2.5 in The SuperBook's NFL odds Week 18 market. Within two minutes, the first move was down to San Fran -1.5. But moves quickly followed to 49ers -2/-2.5/-3.

"There's a good chance this could be noncompetitive, with both teams locked into their seeds. As a result, we sort of defaulted to giving the home team a slight edge," Michaelson said.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 18 Report containing spreads, lines, and trends for every NFL matchup.

Rams vs 49ers Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Check back soon for picks!

Pick: TBD

For more NFL picks, check out Action Network's NFL Week 18: How to Bet Every Game & Every Team.

The One Stat to Know About Rams vs 49ers

Action Network NFL researcher Evan Abrams offers his top betting stat:

Check back soon for betting stats!

For more NFL betting stats, check out Action Network's NFL Week 18 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson