NFL Odds Week 3: Cowboys vs Cardinals Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

NFL Week 3 odds are taking center stage as the regular season roars ahead, presenting a lopsided showdown between the Cowboys and Cardinals on Sunday, September 24. The action kicks off at 4:25 p.m. ET, live from State Farm Stadium in Glendale, Arizona and you can catch it all on FOX.

Here's everything you need to know about the NFL odds for Week 3 Cowboys vs. Cardinals: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Vegas Insider’s Caesars promo code unlocks a lucrative bonus for new sign-ups.

Dallas Cowboys vs Arizona Cardinals Odds

• Opening point spread: Cowboys -12.5
• Opening moneyline: Cowboys -850/Cardinals +550
• Opening total: Over/Under 44 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

UPDATE 3:45 P.M. ET SUNDAY: This game has seen some movement today, with Dallas down to -11.5 in TwinSpires' NFL Week 3 odds market. The Cowboys opened -12.5 and were at -12 earlier today.

However, ticket count is 3/1 and money 4/1 on the Cowboys.

"Dallas is our biggest liability of the [late] slate," Lucas said.

The total is at 43.5, with 57% of tickets/61% of money on the Over.

For more NFL spreads/totals, check out our NFL Odds page.

UPDATE 3 P.M. ET FRIDAY: On Thursday, standout Cowboys cornerback Trevon Diggs suffered a torn ACL in practice, ending his season. But BetMGM didn't budge off its Dallas -12.5 opener, where the line has been all week.

Point-spread ticket count is approaching 2.5/1 and spread money is 4/1 on the double-digit favorite Cowboys.

The total opened at 43.5, topped out at 44.5 Monday and hit a low point of 42 (Over -125) Wednesday afternoon. Shortly thereafter, the number went to 43, where it remains this afternoon. It's two-way action, with 53% of tickets on the Over/59% of money on the Under.

UPDATE 11:30 P.M. ET SUNDAY: Dallas didn't have to face Aaron Rodgers in Week 2, and the result was to be expected. The Cowboys (2-0 SU and ATS) breezed to a 30-10 victory over the Jets, cashing as 8.5-point favorites.

Arizona (0-2 SU and ATS) had a major meltdown in its Week 2 loss. The Cardinals led 20-0 at halftime, but let the Giants come all the way back. Arizona, getting 4.5 points at home, allowed the final 24 points and lost 31-28 on a last-minute field goal.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 3 Report containing spreads, lines, and trends for every NFL matchup.

Cowboys vs Cardinals Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

The Cardinals count as a Kitchen Sink team at 0-2, but Arizona is 2-0 ATS and has actually led both games in the fourth quarter.

The Cowboys, however, are not the Commanders or the Giants.

The Cardinals are competing and should be 2-0 or at least 1-1. I'm not sure you really get the Kitchen Sink bump when your franchise would clearly prefer to go 0-17, but home underdogs of 10-to-14 points are 64-43 ATS over the past two decades (60%), including 5-1 in September.

The numbers say this is the right side, and it's the way to bet the Cards if you want action. Just know that it could be 21-0 after 10 minutes, too.

For more NFL coverage, check out our NFL odds page.

Pick: Cardinals +12.5 (-110)

For more NFL Week 3 picks, check out Action Network's NFL Week 3: How to Bet Every Game & Every Team.

The One Stat to Know About Cowboys vs Cardinals

Action Network NFL researcher Evan Abrams offers his top betting stat:

Dak Prescott has been a double-digit favorite nine times entering this week, and the Cowboys are 8-1 SU, 6-3 ATS. Their only loss came against the Broncos in 2021.

For more NFL Week 3 picks, check out Action Network's NFL Week 3 Betting Trends, Stats, Notes.

Where to place a bet this NFL Season?

• Use our exclusive BetMGM Bonus Code VIBONUS1600 to unlock BetMGM's welcome offer for new sportsbook users!
• Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
• Sports betting is live in North Carolina! Check out our list of North Carolina Sportsbooks and get ready for the NFL season.
• Our DraftKings Promo Code earns users $150 in bonus bets when you bet $5. Sign up today!

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson