NFL Odds Week 5: Lines, Spreads, Betting Trends For Every Game

Patrick Everson Sports Betting Expert

14 minute read

NFL Odds Week 5

NFL odds for Week 5 are short a couple of games, with the first week of byes this season. But there are still a few notable contests among 14 games.

Arguably the marquee matchup in odds for NFL Week 5 is the Buffalo Bills vs. Houston Texans. The first international game of the season is on the schedule, too, with the New York Jets facing the unbeaten Minnesota Vikings in London.

Here’s everything you need to know about the NFL odds Week 5 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 5 odds and action. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

NFL Odds for Every Game of NFL Week 5

Tampa Bay Buccaneers vs Atlanta Falcons Odds

• Opening point spread: Falcons -2.5
• Opening moneyline: Falcons TBA/Buccaneers TBA
• Opening total: Over/Under 42.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

UPDATE 10 P.M. ET SUNDAY: Atlanta (2-2 SU/1-3 ATS) barely eked out a Week 4 home victory over New Orleans. Youngoe Koo drilled a 58-yard field goal in the waning seconds, and the Falcons won 26-24 as 2.5-point home favorites.

Tampa Bay improved to 3-1 SU and ATS with an impressive rebound, after its stunning Week 3 home loss to Denver. The Bucs rolled over Philadelphia 33-16 as 1-point home underdogs.

Bucs-Falcons opened at Atlanta -2.5 and remains there tonight in The SuperBook's NFL Week 5 odds.

"These feel like even teams, so 2.5 is indicative of that," SuperBook risk supervisor Chase Michaelson said. "With both teams coming off wins, and this division looking wide open, I think we'll get a decent amount of public two-way action on this game."

The total nudged from 42.5 to 43 shortly after opening tonight.

New York Jets vs Minnesota Vikings Odds

• Opening point spread: Vikings -2.5
• Opening moneyline: Jets TBA/Vikings TBA
• Opening total: Over/Under 41 points scored
• Time: 9:30 a.m. ET Sunday (NFL Network)

UPDATE 10 P.M. ET SUNDAY: Minnesota is perhaps the most surprising unbeaten team, now sitting at 4-0 SU and ATS. In Week 4, the Vikings built a 28-0 first-half lead vs. Green Bay, then held on for a 31-29 victory catching 2.5 points on the road.

New York (2-2 SU and ATS) saw its modest two-game win streak halted in upset fashion. The Jets closed as 8-point home favorites vs. Denver and lost a slog of a game 10-9.

Jets-Vikings opened at Minnesota -2.5 in The SuperBook's NFL odds Week 5 market. The Vikes briefly adjusted to -2.5 (-120), then returned to -2.5 flat.

"The Vikings continue to be the surprise of the season," SuperBook risk supervisor Chase Michaelson said. "Our Game of the Year line [over the summer] was Jets -4. But we had to argue ourselves down from Vikings -3 on this one.

"The Jets certainly know how to play low-scoring games, so I'm sure the soccer fans in London will appreciate that. The early London game always draws an interesting betting crowd, so it's hard to say what side we'll need."

On the total, The SuperBook crept from 41 to 41.5 tonight.

Buffalo Bills vs Houston Texans Odds

• Opening point spread: Bills -2.5
• Opening moneyline: Bills TBA/Texans TBA
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10 P.M. ET SUNDAY: Houston is 3-1 SU, yet hasn't cashed this season at 0-4 ATS. But Texans nearly covered on final-seconds shenanigans vs. Jacksonville.

Trailing 20-17, Houston got a touchdown with 18 seconds left to go up 24-20. On the ensuing possession, the Jags had to play pitchy-woo-woo on the final play, which almost resulted in a safety. But officials ruled Travis Etienne down at the 1-yard line.

So the Texans failed to cover as 5.5-point home faves.

Buffalo (3-1 SU/2-2 ATS) got roughed up in the Week 4 Sunday night game. The Bills spotted Baltimore a 21-3 first-half lead and couldn't recover in a 35-10 beatdown as 2.5-point road pups.

The SuperBook opened Bills-Texans at Buffalo -2.5. There was no early movement, and that line came off the board once Bills-Ravens kicked off Sunday night. It will go back up Monday morning.

"The Texans are just not very good right now. They were incredibly lucky to beat Jacksonville today, and Buffalo was not lucky to beat Jacksonville last week," SuperBook risk supervisor Chase Michaelson said.

That noted, with Buffalo getting punished by Baltimore, Michaelson said late tonight that the Bills-Texans line would likely be shorter Monday morning.

Baltimore Ravens vs Cincinnati Bengals Odds

• Opening point spread: Ravens -1
• Opening moneyline: Ravens TBA/Bengals TBA
• Opening total: Over/Under 48.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10 P.M. ET SUNDAY: Cincinnati (1-3 SU/2-2 ATS) finally cracked the win column in Week 4. The Bengals took care of Carolina 34-24 laying 4.5 points on the road.

Baltimore (2-2 SU and ATS) squared its record by blasting Buffalo in Week 4. The Ravens led 21-3 midway through the second quarter and rumbled to a 35-10 victory giving 2.5 points at home.

Baltimore opened -1 vs. Cincy in The SuperBook's NFL odds Week 5 market. That line came off the board once Bills-Ravens kicked off Sunday, and it will go back up Monday.

"This will depend on how the Ravens look tonight," SuperBook risk supervisor Chase Michaelson said before Baltimore drilled Buffalo. "But the one thing with Cincy is you just cannot make the totals high enough. The defense is legitimately bad."

Cleveland Browns vs Washington Commanders Odds

• Opening point spread: Commanders -3
• Opening moneyline: Commanders TBA/Browns TBA
• Opening total: Over/Under 43.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10 P.M. ET SUNDAY: Washington (3-1 SU and ATS) just might be the real deal, behind rookie QB Jayden Daniels. In Week 4, the Commanders went to Arizona as 3.5-point underdogs and hammered the Cardinals 42-14.

Daniels completed 26 of 30 passes for 233 yards and a touchdown, with one interception. And he also ran eight times for 47 yards and another TD. All that came after Daniels led Washington to a Week 3 Monday night win at Cincinnati.

Cleveland (1-3 SU and ATS) got out to a 10-0 first-quarter lead at Las Vegas. But the Browns didn't score again until a fourth-quarter fumble-recovery TD and lost 20-16 laying 2.5 points.

Commanders-Browns opened at Washington -3 and moved to -3.5 tonight at The SuperBook.

Carolina Panthers vs Chicago Bears Odds

• Opening point spread: Bears -4
• Opening moneyline: Bears TBA/Panthers TBA
• Opening total: Over/Under 43.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10 P.M. ET SUNDAY: Carolina (1-3 SU and ATS) couldn't build off its Week 3 upset of Las Vegas. The Panthers lost to Cincinnati 34-24 getting 4.5 points at home.

Chicago (2-2 SU/3-1 ATS) held off the Los Angeles Rams 24-18, cashing as 3-point home favorites.

The Panthers-Bears line has already seen a fair amount of movement in The SuperBook's NFL odds Week 5 market. Chicago opened -4, quickly advanced to -4.5/-5, then backtracked to -4.5 and is now -4 again.

The total dipped from 43.5 to 43.

Indianapolis Colts vs Jacksonville Jaguars Odds

• Opening point spread: Jaguars -2.5
• Opening moneyline: Jaguars TBA/Colts TBA
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10 P.M. ET SUNDAY: Jacksonville (0-4 SU/2-2 ATS) can't shake last year's late-season slide, as it's now 1-9 SU in its last 10 games (3-7 ATS). In Week 4, the Jags led at Houston 20-17, but gave up a late touchdown and lost 24-17 as 5.5-point 'dogs.

Indianapolis (2-2 SU/3-1 ATS) put the first blemish on Pittsburgh's record. The Colts hung on for a 27-24 victory catching 2.5 points at home.

Despite Jacksonville being winless, The SuperBook opened Colts-Jaguars at Jags -2.5 (-120) tonight. There's been no early movement.

Miami Dolphins vs New England Patriots Odds

• Opening point spread: Pick
• Opening moneyline: Patriots TBA/Dolphins TBA
• Opening total: Over/Under 35.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10 P.M. ET SUNDAY: New England (1-3 SU/1-2-1 ATS) dug itself into a 20-0 first-half hole at San Francisco. From there, the Pats never threatened in a 30-13 loss getting 10.5 points.

Miami (1-2 SU/0-3 ATS), trying to manage despite not having QB Tua Tagovailoa, still has Week 4 work to do. The Dolphins host Tennessee on Monday night.

With two struggling teams, it seems right to open this game a pick 'em. So that's what The SuperBook did in NFL Week 5 odds. The line and total are stable tonight.

Arizona Cardinals vs San Francisco 49ers Odds

• Opening point spread: 49ers -7
• Opening moneyline: 49ers TBA/Cardinals TBA
• Opening total: Over/Under 49 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

UPDATE 10 P.M. ET SUNDAY: San Francisco (2-2 SU and ATS) halted its two-game losing streak in Week 4. The Niners jumped out to a 20-0 first-half lead vs. New England and breezed to a 30-13 victory giving 10.5 points at home.

Arizona (1-3 SU/2-2 ATS) got run out its own stadium by Jayden Daniels and Washington. The Cardinals, who closed as 3.5-point faves, were down 27-7 in the third quarter and lost 42-14.

Cards-Niners opened at San Fran -7 in The SuperBook's odds for NFL Week 5. The spread is stable, and the total inched from 49 to 49.5 tonight.

Las Vegas Raiders vs Denver Broncos Odds

• Opening point spread: Broncos -1.5
• Opening moneyline: Broncos TBA/Raiders TBA
• Opening total: Over/Under 37.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

UPDATE 10 P.M. ET SUNDAY: Denver (2-2 SU/3-1 ATS) did next to nothing on the road against the New York Jets. And yet that was enough, as the Broncos claimed an ugly 10-9 upset as 8-point underdogs.

Denver got the winning points on a 47-yard Wil Lutz field goal with 8:55 remaining.

Las Vegas (2-2 SU and ATS) fell behind 10-0 to Cleveland in the first quarter. But the Raiders rebounded to win 20-16 as 2.5-point home underdogs.

The SuperBook opened Raiders-Broncos at Denver -1.5 and stuck there tonight. The total fell from 37.5 to 37.

Green Bay Packers vs Los Angeles Rams Odds

• Opening point spread: Packers -3.5
• Opening moneyline: Packers TBA/Rams TBA
• Opening total: Over/Under 45.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

UPDATE 10 P.M. ET SUNDAY: Green Bay (2-2 SU and ATS) got Jordan Love back under center, but found itself down 28-0 in the second quarter. Love helped the Packers rally, but it wasn't enough in a 31-29 loss giving 2.5 points at home.

Los Angeles (1-3 SU and ATS) couldn't carry the momentum from its Week 3 upset win over San Francisco. In Week 4, the Rams fell to Chicago 24-18 catching 3 points on the road.

Green Bay opened -3.5 vs. L.A. in The SuperBook's NFL odds Week 5 market. The spread hasn't moved tonight, but the total made a stop at 46 on its way up to 47.

New York Giants vs Seattle Seahawks Odds

• Opening point spread: Seahawks -6
• Opening moneyline: Seahawks TBA/Giants TBA
• Opening total: Over/Under 41.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

UPDATE 10 P.M. ET SUNDAY: Seattle (3-0 SU/1-1-1 ) still has to get through Week 4. The Seahawks travel to Detroit for a Monday night game.

New York (1-3 SU/2-2 ATS) stayed close with Dallas in the Week 4 Thursday night game. But the Giants ultimately fell short 20-15 while cashing as 5.5-point underdogs.

The SuperBook opened Giants-Seahawks at Seattle -6 and stuck there tonight. Likewise, the total is steady at 41.5.

Dallas Cowboys vs Pittsburgh Steelers Odds

• Opening point spread: Steelers -2.5
• Opening moneyline: Cowboys TBA/Steelers TBA
• Opening total: Over/Under 41 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

UPDATE 10 P.M. ET SUNDAY: Dallas (2-2 SU/1-3 ATS) wasn't exactly impressive in the Week 4 Thursday nighter, but halted a two-game SU skid. The Cowboys were 5.5-point road favorites vs. the New York Giants and held on for a 20-15 victory.

Pittsburgh (3-1 SU and ATS) finally took its first setback of the season. The Steelers were 2.5-point favorites at Indianapolis and couldn't overcome a 17-0 first-half deficit, losing 27-24.

Pittsburgh opened -2.5 vs. Dallas on The SuperBook's NFL Week 5 odds board. Within about 30 minutes tonight, the Steelers receded to -2. The total climbed from 41 to 41.5/42.

"The Steelers' defense looked mortal today, which is interesting," SuperBook risk supervisor Chase Michaelson said. "Dallas is kind of lollygagging through the first 4 weeks of the season. But the Cowboys are still in decent position.

"We'll probably need Dallas. It feels like this game should be played during the day at the Orange Bowl or Sun Devil Stadium."

New Orleans Saints vs Kansas City Chiefs Odds

• Opening point spread: Chiefs -5.5
• Opening moneyline: Chiefs TBA/Saints TBA
• Opening total: Over/Under 43 points scored
• Time: 8:15 p.m. ET Monday (ESPN)

UPDATE 10 P.M. ET SUNDAY: Kansas City (4-0 SU/2-1-1 ATS) didn't exactly light it up against a banged-up L.A. Chargers outfit. But the Chiefs scratched out a 17-10 win, pushing as 7-point road favorites.

New Orleans (2-2 SU/3-1 ATS) got an Alvin Kamara TD run with a minute left to take a 24-23 lead at Atlanta. But the Saints couldn't make it hold up, losing 26-24 on a final-seconds 58-yard field goal.

Saints-Chiefs opened as K.C. -5.5 and fell to -5 after a couple hours tonight. The total saw more movement, going from 43 to 44, then falling to 43.5/42.5 in the NFL odds Week 5 market.

"K.C. just keeps winning and looking worse every week doing it. The public will bet them this week. But I wouldn't be surprised to see the sharps on New Orleans, with all of K.C.'s injuries," SuperBook risk supervisor Chase Michaelson said.

The Chiefs lost running back Isiah Pacheco to a broken fibula in Week 2. In Week 4, wideout Rashee Rice suffered a knee injury. Rice will have an MRI on Monday, and he could be shelved for the season

"The Chiefs are like Northwestern Mutual, though. The public trusts Patrick Mahomes and Andy Reid, and the other players are just details," SuperBook risk supervisor Chase Michaelson said. "Taylor Swift was absent in L.A. today. We need to check the Eras Tour schedule."

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson