NFL Odds Week 5: Lines, Spreads, Betting Trends For All 14 Games

Patrick Everson Sports Betting Expert

17 minute read

2025 NFL Odds Week 5

NFL odds for Week 5 feature a few games between teams that reached the postseason last year.

For the fourth straight week, the Philadelphia Eagles face a playoff team, hosting the Denver Broncos. Other interesting contests in NFL Week 5 odds: Houston Texans vs. Baltimore Ravens and Washington Commanders vs. Los Angeles Chargers.

Here’s everything you need to know about the NFL odds Week 5 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on Week 5 NFL odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Tina MacIntyre-Yee/Imagn Images)

NFL Odds for Every Game of NFL Week 5

San Francisco 49ers vs. Los Angeles Rams Odds

• Opening point spread: Rams -3.5
• Opening moneyline: Rams TBA/49ers TBA
• Opening total: Over/Under 47.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

Check out our Thursday Night Football best bet.

MIDWEEK UPDATE: With 30 hours or so until kickoff, Los Angeles is out to a 7-point favorite at Borgata Sports, from a -3.5 opener in NFL odds Week 5. That's largely due to San Fran QB Brock Purdy (toe) being questionable at the moment, with oddsmakers not expecting him to play.

But the Niners are banged up elsewhere, as well. Wideouts Jauan Jennings (ankle/ribs) and Ricky Pearsall (knee) are both questionable, and the defense has injuries, too.

"Lots of injuries across the league have been moving numbers, and that is certainly the case with this game," Borgata sportsbook director Tom Gable said. "We’ve seen almost all Rams money here, both on the spread and moneyline.

"Mac Jones has looked decent thus far in his limited time for the Niners this season. But we will see if anyone wants to buy in on him at +7."

The total is at 46.5 (Over -115) after opening at 47.5.

OPENING ODDS UPDATE: Los Angeles (3-1 SU and ATS) rallied for a Week 4 victory, bouncing back from a stunning ending at Philadelphia in Week 3. The Rams trailed 20-13 with 8:58 remaining vs. Jacksonville, then put up two touchdowns for a 27-20 win laying 3.5 points at home.

San Francisco (3-1 SU and ATS) got Brock Purdy back under center, but it wasn't enough to dodge their first loss. The 49ers dug themselves into a 14-3 second-quarter hole and never fully got out of it, losing to Jacksonville 26-21 as 3-point home favorites.

In the NFL Week 5 odds market, The SuperBook opened L.A. -3.5 at 7 p.m. ET Sunday night, with no movement as of 9:15 p.m. ET.

"We took some money on 49ers +3.5/+3 on the lookahead line last week. But we still felt fine with opening this game Rams -3.5, after watching San Francisco today. The public will be on Rams," SuperBook vice president John Murray said.

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Minnesota Vikings vs. Cleveland Browns Odds

• Opening point spread: Vikings -4
• Opening moneyline: Vikings TBA/Browns TBA
• Opening total: Over/Under 38 points scored
• Time: 9:30 a.m. ET Sunday (NFL Network)

Our complete Vikings vs. Browns preview details a best bet for the London game.

OPENING ODDS UPDATE: Minnesota (2-2 SU and ATS) rallied from a 24-6 deficit in the fourth quarter, but ran out of time vs. Pittsburgh. The Vikings fell 24-21 as 2.5-point neutral-site favorites in Dublin, Ireland.

Cleveland (1-3 SU/2-2 ATS) upset Green Bay last week, but couldn't repeat against another NFC North standout. The Browns tumbled to Detroit 34-10 getting 10 points on the road.

Minnesota remains in Europe for a second straight week, with the Vikings-Browns game in London. The SuperBook opened the Vikes -4, went to -4.5 for a couple hours and is back at -4 Sunday night. The total is also on the move, from 38 to 37.5/37.

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Denver Broncos vs. Philadelphia Eagles Odds

• Opening point spread: Eagles -5.5
• Opening moneyline: Eagles TBA/Broncos TBA
• Opening total: Over/Under 44 points scored
• Time: 1 p.m. ET Sunday (CBS)

Our complete Broncos vs. Eagles preview features a best bet for this massive matchup.

MIDWEEK UPDATE: Borgata Sports sits in Atlantic City, a stone's throw from Philadelphia. So it usually has no issue drawing Eagles dollars. But it took some favorable movement to do so in NFL Week 5 odds.

"We opened this at Eagles -5.5 with the broader market and didn’t get many [Philly] takers, even in Eagles country," Borgata sportsbook director Tom Gable said Wednesday afternoon. "We are down to Eagles -3.5 and now are attracting a decent amount of money on Philadelphia.

"The fact that we haven’t seen a complete-game effort from the Eagles yet this season hasn’t cost them in the win category."

Borgata's total is down a point from 44.5 to 43.5.

EARLY WEEK UPDATE: Denver (2-2 SU/1-3 ATS) finally covered for bettors for the first time this season. The Broncos rolled over Cincinnati 28-3 on Monday night.

During the Bengals-Broncos game, The SuperBook took Broncos-Eagles off the board. Broncos-Eagles went back up Tuesday morning at Philly -4. That's down 1.5 points from Sunday's Eagles -5.5 opener, with stops at -5/-4.5 late Sunday night/Monday afternoon, respectively.

OPENING ODDS UPDATE: Philadelphia (4-0 SU/3-1 ATS) gave away most of two 18-point leads, 24-6 at halftime and 31-13 late in the third quarter. But the Eagles held on for a 31-25 victory at Tampa Bay, cashing as 3.5-point favorites

Denver (1-2 SU/0-3 ATS) still has Week 4 work to do. The Broncos host Cincinnati on Monday night.

Still, The SuperBook went ahead and opened Philly as 5.5-point home chalk in the NFL odds Week 5 market. There's been no movement Sunday night.

"We haven't seen much on the game yet. But the Eagles will be a popular moneyline and teaser option," SuperBook VP John Murray said. "So I'm pretty sure we’ll be rooting for the Broncos, who will be coming off a short week."

Houston Texans vs. Baltimore Ravens Odds

• Opening point spread: Ravens -3.5
• Opening moneyline: Ravens TBA/Texans TBA
• Opening total: Over/Under 43 points scored
• Time: 1 p.m. ET Sunday (CBS)

Our experts detail a best bet in our Ravens vs. Texans game preview.

MIDWEEK UPDATE: Ravens QB Lamar Jackson is doubtful to play, and this line has made a huge move when compared with last week's lookahead number. The Texans are now 1-point favorites in Borgata Sports' NFL Week 1 odds.

The spread opened at Ravens -6.5 Monday morning, after sitting at -9.5 on last week's lookahead. Within a few hours, with more certainty around Jackson, the line tumbled to Baltimore -3.5.

But the Ravens are banged up elsewhere, too. Left tackle Ronnie Stanley and center Tyler Linderbaum are questionable, and a host of defensive players are questionable. Plus, linebacker Roquan Smith (hamstring) and defensive back Marlon Humphrey (calf) are doubtful.

So by Tuesday afternoon, the line jumped the fence to Texans -1 and got as far as -2.5. It dialed back some by Wednesday night, to Houston -1 (-115). As of 1 p.m. ET Thursday, the Texans are -2.

"Another game with a big line move due to injuries. Lamar Jackson is in the top three players in the league in terms of value to the spread. We have seen that play out here," Borgata sportsbook director Tom Gable said. "But it isn’t just Lamar being unavailable.

"The Ravens have been decimated with injuries on both sides of the ball."

Borgata's total is down to 40.5 from a 43.5 opener.

EARLY WEEK UPDATE: Lamar Jackson's status is still unclear Monday night, after he suffered a hamstring injury Sunday in Baltimore's loss at Kansas City. But Monday afternoon, The SuperBook went up with a number that assumes the QB is out: Ravens -3.5.

And that number dipped to Ravens -3 within a few minutes. Compare that with last week's lookahead number: Ravens -10, with a modest dip to -9.5. It's fair to say Jackson, a two-time NFL MVP, is worth at least 6 points to the number.

But at least a small part of the big adjustment is that Baltimore is banged up all around. Pro Bowl defensive tackle Nnamdi Madubuike suffered a neck injury Sunday and is out for the season, and the defense has other injuries, as well.

On offense, left tackle Ronnie Stanley (ankle) is questionable this week.

OPENING ODDS UPDATE: Baltimore, a preseason favorite in Super Bowl odds, is now 1-3 SU and ATS facing its third playoff team in four weeks. The Ravens were 2.5-point road favorites vs. Kansas City, but couldn't keep pace in a 37-20 loss.

That wasn't the only big loss. Baltimore QB Lamar Jackson exited with a hamstring injury late in the third quarter and did not return.

It took four weeks, but Houston (1-3 SU and ATS) finally got its first W. The Texans blanked Tennessee 26-0 giving 7.5 points at home.

With Jackson's status unclear, The SuperBook held off putting up a Texans-Ravens number in Week 5 NFL odds. SuperBook VP John Murray noted that last week's lookahead line was Baltimore -10, but that will change significantly if Cooper Rush is the starter.

Dallas Cowboys vs. New York Jets Odds

• Opening point spread: Cowboys -1.5
• Opening moneyline: Cowboys TBA/Jets TBA
• Opening total: Over/Under 46 points scored
• Time: 1 p.m. ET Sunday (FOX)

This game is going to have tons of points. Check out our complete Cowboys vs. Jets preview.

EARLY WEEK UPDATE: New York (0-4 SU/1-3 ATS) is still seeking its first victory on the field. In a Week 4 Monday night game, the Jets fell short at Miami 27-21 catching 2.5 points.

Once Jets-Dolphins kicked off, The SuperBook took Cowboys-Jets off the board. Cowboys-Jets went back up Tuesday morning at Dallas -2.5, up from Sunday's -1.5 opener.

OPENING ODDS UPDATE: Dallas (1-2 SU and ATS) is in the midst of its Week 4 assignment right now. The Cowboys are hosting the Green Bay Packers in Sunday Night Football.

New York (0-3 SU/1-2 ATS) also has Week 4 work remaining, with the Jets at Miami on Monday night.

The SuperBook opened Cowboys-Jets at Dallas -1.5, but the game came off the board once Cowboys-Packers kicked off. Cowboys-Jets will go back up Monday morning.

New York Giants vs. New Orleans Saints Odds

• Opening point spread: Giants -1.5
• Opening moneyline: Giants TBA/Saints TBA
• Opening total: Over/Under 42.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New York (1-3 SU/2-2 ATS) got the upset of Week 3 behind rookie starting QB Jaxson Dart. The Giants closed as 6-point home underdogs and held on for a 21-18 victory over the Los Angeles Chargers.

New Orleans (0-3 SU/1-3 ATS) was the biggest underdog of the season so far, catching 14.5 points at Buffalo. Yet with 8:53 remaining, after a field goal, the Saints were within 21-19. But that was it for New Orleans in a 31-19 loss, though the Saints covered for the first time this season.

The SuperBook opened Giants-Saints at New York -1.5 in the NFL odds Week 5 market. The Giants are already up a tick to -2 Sunday night.

Las Vegas Raiders vs. Indianapolis Colts Odds

• Opening point spread: Colts -6.5
• Opening moneyline: Colts TBA/Raiders TBA
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Indianapolis (3-1 SU and ATS) were in position to stay unbeaten on the field and at the betting window. Trailing the L.A. Rams 13-10, the Colts put up a touchdown and a field goal in the first half of the fourth quarter to go up 20-13.

But Indy gave up two touchdowns in the final minutes and lost 27-20 as 3.5-point road underdogs.

Las Vegas (1-3 SU and ATS) had a potential win on the foot of Daniel Carlson in the final minute vs. Chicago. But the 54-yard field goal was blocked, and the Raiders lost 25-24 as 1.5-point home favorites.

Indianapolis has already toggled from -6.5 to -7 and back to -6.5 on Sunday night in The SuperBook's NFL Week 5 odds. The total went from 49.5 to 49.

Miami Dolphins vs. Carolina Panthers Odds

• Opening point spread: Pick 'em
• Opening moneyline: Panthers TBA/Dolphins TBA
• Opening total: Over/Under 45.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

EARLY WEEK UPDATE: Miami (1-3 SU/2-2 ATS) finally got its first SU win of the season. Playing Monday night, the Dolphins built a 24-10 lead by late in the third quarter and held on to beat the New York Jets 27-21. Miami cashed as a 2.5-point home favorite.

The SuperBook opened Dolphins-Panthers at pick 'em Sunday night, and the matchup came off the board once Jets-Dolphins kicked off. On Tuesday morning, The Superbook reopened at Panthers -1.5, but by midafternoon, the game was back to pick 'em.

OPENING ODDS UPDATE: Miami (0-3 SU/1-2 ATS) has Week 4 work remaining, as the Dolphins host the Jets in the opener of a Monday night twinbill.

Carolina (1-3 SU/2-2 ATS) didn't look like the team that blanked Atlanta 30-0 in Week 3. The Panthers, 5.5-point pups at New England took a 6-0 lead, then gave up 42 straight points in a 42-13 loss.

In Week 5 NFL odds, The SuperBook opened this game at pick Sunday night, with no movement so far.

Tampa Bay Buccaneers vs. Seattle Seahawks Odds

• Opening point spread: Seahawks -2.5
• Opening moneyline: Seahawks TBA/Buccaneers TBA
• Opening total: Over/Under 46 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

Our expert has a pick for this game in our Seahawks vs. Buccaneers preview.

MIDWEEK UPDATE: Seattle opened as 2.5-point home chalk in Borgata Sports' NFL odds Week 5 market and is now up to -3.5.

"It's certainly an interesting matchup, with both teams off to good starts," Borgata sportsbook director Tom Gable said Wednesday. "Early Seahawks money pushed this as high as 3.5, but I could see this settle at 3 before all is said and done."

Gable noted a key injury for the Bucs, as well, with star wideout Mike Evans (hamstring) already deemed out this week.

"No Mike Evans again for Tampa. The Bucs have now lost six in a row when Evans misses a game. It’s a different offense without him, but we have seen a bit of money come in here on the Tampa moneyline," Gable said.

Borgata's total is steady at 44.5.

OPENING ODDS UPDATE: Seattle (3-1 SU and ATS) was in control at Arizona in the Week 3 Thursday nighter, leading 20-6 with 9:33 remaining. Then the Seahawks barely avoided overtime, winning on a last-second field goal 23-20 as 1.5-point favorites.

The Seahawks are on a 3-0 SU and ATS surge since a Week 1 loss to San Francisco.

Tampa Bay (3-1 SU/2-2 ATS) twice found itself in 18-point holes vs. Philadelphia, down 24-6 at halftime and 31-13 late in the third quarter. The Bucs rallied but came up short, losing 31-25 as 3.5-point home underdogs.

For Bucs-Seahawks, The SuperBook saw a little early shove on Seattle in the NFL odds Week 5 market.

"We opened Seattle -2.5 (-110), took money on the Seahawks and moved to -2.5 (-120). I’ll be interested to see how they bet this game from here," SuperBook vice president John Murray said Sunday night.

The total is the bigger mover as of 9:30 p.m. ET Sunday. It opened at 46 and within an hour went to 45.5/45.

Tennessee Titans vs. Arizona Cardinals Odds

• Opening point spread: Cardinals -9.5
• Opening moneyline: Cardinals TBA/Titans TBA
• Opening total: Over/Under 41.5 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Arizona (2-2 SU and ATS) saw a big late fourth-quarter rally come up short at home vs. Seattle. The Cards scored two touchdowns in the final six minutes, erasing a 20-6 deficit Thursday night.

But Arizona, a 1.5-point 'dog, then fell 23-20 on a final-seconds field goal

Tennessee (0-4 SU/1-3 ATS) got zero offense and remained at zero wins. The Titans tumbled 26-0 getting 7.5 points at Houston.

Titans-Cardinals opened at Arizona -9.5 in The SuperBook's NFL odds Week 5 market. There's no movement so far Sunday night. The total, however, is on the move early, from 41.5 to 41/40.5.

Washington Commanders vs. Los Angeles Chargers Odds

• Opening point spread: Chargers -2.5
• Opening moneyline: Chargers TBA/Commanders TBA
• Opening total: Over/Under 48.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

MIDWEEK UPDATE: Borgata Sports opened L.A. -3 and has bounced between -3/-2.5 the first half of the week. The Chargers were -3 early Wednesday afternoon, prior to the Commanders announcing the status of QB Jayden Daniels.

"Daniels was expected to play in this one. He's now been medically cleared and is practicing with the team," Borgata sportsbook director Tom Gable said. "The 3s out there may not last too much longer. This game will probably close lower once Daniels is announced as the starter."

That's precisely what happened. Shortly after Gable's comment, the Chargers dipped to -2.5 (-120). Borgata's total is up a tick, from 47.5 to 48.

OPENING ODDS UPDATE: Los Angeles (3-1 SU and ATS) was dealt its first setback of the season, and to an unlikely suspect. The Chargers, 6-point road favorites, were down double digits at two junctures and lost to the New York Giants 21-18.

Washington (2-2 SU and ATS) once again didn't have Jayden Daniels (knee), but it didn't work out as well as in Week 3. The Commanders fell to Atlanta 34-27 as 2.5-point road 'dogs.

Los Angeles is a stable 2.5-point home favorite Sunday night in The SuperBook's Week 5 NFL odds.

"No action yet here. We expect Daniels to be back for this one. But I said that last Sunday, too," SuperBook VP John Murray said.

The total opened at 48.5 and nudged to 48.

Detroit Lions vs. Cincinnati Bengals Odds

• Opening point spread: Lions -8.5
• Opening moneyline: Lions TBA/Bengals TBA
• Opening total: Over/Under 49.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

EARLY WEEK UPDATE: Cincinnati (2-2 SU/1-3 ATS) looks utterly rudderless without Joe Burrow. In a Week 4 Monday night game, the Bengals got rolled 28-3 as 7.5-point underdogs at Denver.

Over the past two games, Cincy has been outscored 76-13.

On Sunday night, The SuperBook opened Bengals-Lions at Detroit -8. The game came off the board once Bengals-Broncos kicked off Monday. Bengals-Lions went back up Tuesday morning at Detroit -10.

OPENING ODDS UPDATE: Detroit (3-1 SU and ATS) found itself down 7-0 to Cleveland in the first quarter. Then the Lions scored the next 20 points and 34 of the final 37, rolling to a 34-10 victory as 10-point home faves.

Cincinnati (2-1 SU/1-2 ATS) isn't out of Week 4 yet. The Bengals, still without QB Joe Burrow (toe) likely until December, visit Denver on Monday night.

In NFL Week 5 odds, The SuperBook opened and remains at Lions -8.5 Sunday night. The total crept from 49.5 to 49.

New England Patriots vs. Buffalo Bills Odds

• Opening point spread: Bills -9.5
• Opening moneyline: Bills TBA/Patriots TBA
• Opening total: Over/Under 49 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

MIDWEEK UPDATE: Buffalo opened as 8.5-point home chalk in Borgata Sports' NFL Week 5 odds and is -7.5 Wednesday afternoon.

"Some of the bridge jumpers who laid huge money last week on the Bills moneyline against the Saints had a little bit of a sweat there, until Josh Allen & Co. decided to put the game away," Borgata sportsbook director Tom Gable said.

"But the Bills still failed to cover the opening and closing number. Now, for a second straight week, we have seen their opponent take money. Bills moneyline will still be a popular play, though. And with this being the Sunday night game, it will be tied into the majority of moneyline parlays."

Borgata's total inched from 49.5 to 50.

OPENING ODDS UPDATE: Buffalo (4-0 SU/2-2 ATS) got a much tougher test than expected in Week 4 vs. New Orleans. The Bills led just 21-19 with 8:53 remaining, but closed it out with the final 10 points in a 31-29 victory laying 14.5 points at home.

Not surprisingly, Buffalo was the most-selected team in Circa Survivor Week 4.

New England (2-2 SU and ATS) gave up an early TD to fall behind Carolina 6-0. But the Patriots then punched up the next 42 points en route to a 42-13 win as 5.5-point home favorites.

The SuperBook opened Bills-Pats at Buffalo -9.5 and backed up to -9 within about an hour Sunday night. The total also saw a half-point adjustment, from 49.5 to 49.

Kansas City Chiefs vs. Jacksonville Jaguars Odds

• Opening point spread: Chiefs -3
• Opening moneyline: Chiefs TBA/Jaguars TBA
• Opening total: Over/Under 44.5 points scored
• Time: 8:15 p.m. ET Monday (ABC/ESPN)

MIDWEEK UPDATE: Kansas City opened -3 in Borgata Sports' NFL odds Week 3 market and is now up to -3.5.

"In the early going, it’s been all Chiefs and Over money. But handle overall has been light," Borgata sportsbook director Tom Gable said. "The Chiefs may have gotten some of their mojo back last week in beating up on an injured Baltimore Ravens team.

"But this will be a tough test on the road, against a Jaguars team that has gotten off to a decent start."

The total is up to 46.5 from a 44.5 opener.

OPENING ODDS UPDATE: Kansas City (2-2 SU and ATS) took four weeks, but finally got to .500 on the season. And in impressive fashion. The Chiefs closed as 2.5-point home pups to Baltimore, but rolled to a 37-20 victory.

Jacksonville (3-1 SU and ATS) is off to a better start than most expected. In Week 4, the Jags built a 17-6 halftime lead at San Francisco and held on for a 26-21 victory getting 3 points.

"We saw sharp action on Jacksonville +3.5 on the lookahead line. So we felt comfortable re-opening the game at K.C. -3, even after the Chiefs' impressive win today," SuperBook vice president John Murray said.

There was no Sunday night movement with the spread, but the total went from 44.5 to 45/45.5 in NFL Week 5 odds.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson