NFL Odds Week 5: Cowboys vs 49ers Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

The fifth Sunday of the 2023 NFL season concludes with a heavyweight NFC showdown between the Cowboys and 49ers, with San Francisco tagged as a 3.5-point home favorite, according to the Week 5 betting odds. Coverage begins from Levi's Stadium in Santa Clara on Sunday, October 8 at 8:20 p.m. ET on NBC.

Here's everything you need to know about the NFL odds for Week 5 Cowboys vs 49ers: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Dallas Cowboys vs San Francisco 49ers Odds

• Opening point spread: 49ers -3.5
• Opening moneyline: 49ers -185/Cowboys +155
• Opening total: Over/Under 45.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

UPDATE 5 P.M. ET WEDNESDAY: San Fran opened as 4-point chalk in TwinSpires Sportsbook's NFL odds Week 5 market, and the Niners are down to -3.5. The 49ers are attracting 72% of early spread bets, but spread money is much closer, at 53% on San Francisco.

"This is easily the game of the week. It's attracted the most handle so far," Lucas said. "Sharp play on Cowboys +4."

The total inched down from 45.5 to 45, with 57% of tickets on the Over/59% of money on the Under.

UPDATE 11 P.M. ET SUNDAY: San Francisco (4-0 SU/3-1 ATS) hopes to maintain its status as the favorite on the Super Bowl odds board. In Week 4, the Niners had a little difficulty with Arizona, but ultimately won 35-16. San Fran got a TD with under two minutes left to cover the hefty 14.5-point spread.

Meanwhile, Dallas bounced back big after a stunning Week 3 loss at Arizona. The Cowboys (3-1 SU and ATS) hammered New England 38-3 giving 6 points at home.

The Cowboys and Niners met in the NFC divisional round last season. San Fran won 19-12 as a 3.5-point home favorite.

"We're up to Niners -4, which is where we started seeing some Cowboys bets come in," Degnon said. "Dallas will be a trendy 'dog in this one, but San Francisco always gets good action, too."

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 5 Report containing spreads, lines, and trends for every NFL matchup.

Cowboys vs 49ers Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Both offenses are rolling, but I still trust the defenses better. Dallas continues to stall in the red zone and may not get its usual YAC opportunities against this terrific tackling Niners defnese, and the Cowboys defense leads the league in passing and overall Defensive DVOA and should hold its own too.

Remember how low-scoring those two playoff matchups were the last two seasons, just 31 and 40 points total. Both teams can be run on a bit, which moves the clock, and Dak Prescott road unders are 30-19 lifetime (61%). Primetime unders are 60% since 2019, including 9-4 (69%) through the first four weeks of the new season.

I'm not expecting a shootout. Instead, I'm looking for more of a cagey match as these teams feel each other out and play the long game for what both will expect to be the first of two meetings. I don't see a ton of big plays or scoring.

It honestly wouldn't stun me if one side just "solved" the other and we end up with a blowout and one offense laying a bit of a goose egg, but that probably hits the under too. I see a script similar to the playoff games, with stalled trips leading to field goals and a close game without much scoring that comes down to Prescott or Purdy making the plays late. The line feels right, but I like the under.

Pick: Under 45 (-110)

For more NFL Week 5 picks, check out Action Network's NFL Week 5: How to Bet Every Game & Every Team.

The One Stat to Know About Cowboys vs 49ers

Action Network NFL researcher Evan Abrams offers his top betting stat:

Dak Prescott is 23-12 SU and 21-13-1 ATS in night games. He’s the sixth-most profitable QB ATS over the last 20 years at night. The highest SU win percentage in night games, last 20 years (min. 20 starts): Peyton Manning, Patrick Mahomes, Tom Brady, Carson Wentz, Russell Wilson, and then Prescott.

For more NFL Week 5 betting stats, check out Action Network's NFL Week 5 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson