NFL Odds Week 6: 49ers vs Browns Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

In Week 6 of the NFL season, the 49ers journey to Cleveland for an afternoon non-conference battle against the Browns. The odds favor San Francisco by five points as they aim to stay undefeated this Sunday. Catch all the action live from Cleveland Browns Stadium on Sunday, October 15 at 1:00 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for Week 6 49ers vs Browns: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

San Francisco 49ers vs Cleveland Browns Odds

• Opening point spread: 49ers -3
• Opening moneyline: 49ers -220/Browns +180
• Opening total: Over/Under 41.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10 A.M. ET SUNDAY: Three hours pre-kick, the Niners are laying 9.5 points at BetMGM. That's well up from Monday's -4.5 opener, bolstered by two factors: Bettors piling on San Fran early in the week after its blowout win over Dallas; and late in the week, Browns QB Deshaun Watson ruled out with a rotator cuff injury.

PJ Walker will start for Cleveland.

Spread tickets are running almost 8/1 and spread money 9/1 on the 49ers.

The total plummeted from 42 to 35.5 by Thursday, with several stops along the way, and is now 36. Along with Watson's absence, weather could be an issue, with wind and rain expected in Cleveland today. That said, the Over is seeing 70% of tickets/73% of money.

UPDATE 5:30 P.M. ET WEDNESDAY: This line has been on the move all week, thanks to the Niners' beatdown of the Dallas Cowboys on Sunday night. TwinSpires opened San Fran -5, ran out to -6.5, then this afternoon went to -7.

Early ticket count is 4/1 and early money 8/1 49ers on the spread.

"The 49ers look unstoppable, and bettors are coming in waves to bet them. Our biggest liability of the week is currently 49ers spread. Every teaser and moneyline parlay has the 49ers, as well," TwinSpires' Zachary Lucas said.

The total moved from 38.5 to 37.5 at TwinSpires, the lowest total on the board by a significant amount. Ravens-Titans and Eagles-Jets are both at 41. The Over is seeing 60% of early tickets, while 57% of early money is on the Under.

Along with the Niners' dominance, the Browns' injury situation contributed to moves on the spread and total. Cleveland QB Deshaun Watson (shoulder) is questionable, as are three offensive lineman and star defensive end Myles Garrett (foot).

UPDATE NOON ET MONDAY: In the wake of San Fran's blowout win over Dallas, The SuperBook reopened Cowboys-49ers this morning at Niners -4.5, up 1.5 points from Sunday evening's -3 opener.

That jump was pretty much expected, as The SuperBook's Chase Michaelson noted in his Sunday night comments (see below).

The total also fell back to 39, down 2.5 points.

UPDATE 11 P.M. ET SUNDAY: San Francisco (5-0 SU/4-1 ATS) looks to be a worthy favorite in the Super Bowl odds market. In the Week 5 Sunday nighter against Dallas, the Niners barreled to a 42-10 victory laying 3.5 points at home.

Cleveland (2-2 SU and ATS) had its bye in Week 5, and probably needed it. In Week 4, the Browns got waxed 27-3 as 1.5-point home underdogs to Baltimore.

"Nothing changed from our [lookahead] line," Michaelson said, noting 49ers-Browns came off the board during the Cowboys-49ers game. "The 49ers are the highest power-rated team in the league right now, which shows you how much respect we have for Cleveland – particularly its defense – that this line is only 3."

That said, with San Fran blowing out Dallas, Michaelson anticipates this line climbing, perhaps as soon as it reopens Monday morning. 

Check out VI’s BetRivers bonus code offer before placing your bets on 49ers vs. Browns.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 6 Report containing spreads, lines, and trends for every NFL matchup.

49ers vs Browns Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Check back soon for picks!

Pick: TBD

For more NFL picks, check out Action Network's NFL Week 6: How to Bet Every Game & Every Team.

The One Stat to Know About 49ers vs Browns

Action Network NFL researcher Evan Abrams offers his top betting stat:

Check back soon for betting stats!

For more NFL betting stats, check out Action Network's NFL Week 6 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson