NFL Odds Week 6: Cardinals vs Rams Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

In Week 6 of the NFL season, the Rams look to rebound against the Cardinals an NFC West battle. The odds favor Los Angeles by six points as they seek their first home victory of the season. Catch all the action live from SoFi Stadium in Inglewood on Sunday, October 15 at 4:25 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for Week 6 Cardinals vs Rams: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

Arizona Cardinals vs Los Angeles Rams Odds

• Opening point spread: Rams -6
• Opening moneyline: Rams -270/Cardinals +220
• Opening total: Over/Under 45.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

UPDATE 1 P.M. ET SUNDAY: After opening -6, L.A. toggled between -6.5 and -7 early in the week and has been steady at -7 since Tuesday. The Rams are currently -7 (-115), with spread tickets 3/1 and spread money 2/1 on Los Angeles.

The total opened at 46 and climbed to 48.5 by Tuesday morning, with multiple stops along the way. On Saturday, the number dipped to 47.5, where it remains now. Current Caesars splits aren't available.

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UPDATE 3 P.M. ET FRIDAY: BetMGM opened the Rams -6 and on Tuesday went to -6.5 and -7, with no movement since. But it's not overwhelming L.A. spread play, at 60% of tickets/62% of money.

The total also has seen no movement since Tuesday, after opening 46.5 and making stops at 47.5 and 48 on the way to 48.5. The Over is taking 62% of tickets at BetMGM, but money is running dead even.

UPDATE 11 P.M. ET SUNDAY: Los Angeles (2-3 SU/3-1-1 ATS) got Cooper Kupp back in Week 5, but it wasn't enough against Philadelphia. The Rams fell 23-14 catching 3.5 points at home.

Arizona (1-4 SU/3-2 ATS) kept it close for three quarters against Cincinnati. But the Cards got outscored 10-0 in the final frame, losing 34-20 as 3-point home pups.

The Cards-Rams line has bounced around a bit tonight at The SuperBook, from L.A. -6 to -5.5, then back to -6. The total also got some adjusting, climbing 1.5 points to 47 in the NFL odds Week 6 market.

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Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 6 Report containing spreads, lines, and trends for every NFL matchup.

Cardinals vs Rams Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction: I'm still not sure I have a great read on either of these teams, but I love the offenses and I'm expecting fireworks here. A Kupp TD fits the script in what should be a high-scoring division game, so I'll play both together as a Same Game Parlay at FanDuel at +205.

Pick: Over 47.5 & Kupp TD SGP (+205 at FanDuel)

For more NFL picks, check out Action Network's NFL Week 6: How to Bet Every Game & Every Team.

The One Stat to Know About Cardinals vs Rams

Action Network NFL researcher Evan Abrams offers his top betting stat: The Cardinals have struggled vs. NFC West recently. They are 1-9 ATS in their last 10 games in the spot. They have won one road game SU in the last calendar year – against the Rams (1-7 SU).

For more NFL betting stats, check out Action Network's NFL Week 6 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson