NFL Odds Week 6: Colts vs Jaguars Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

The NFL betting odds see the Colts as five-point road underdogs against the Jaguars in Week 6, who enter fresh off of back-to-back wins in London. Coverage begins from EverBank Stadium in Jacksonville on Sunday, October 15 at 1:00 p.m. ET on CBS.

Here's everything you need to know about the NFL odds for Week 6 Colts vs Jaguars: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

Indianapolis Colts vs Jacksonville Jaguars Odds

• Opening point spread: Jaguars -5.5
• Opening moneyline: Jaguars -220/Colts +180
• Opening total: Over/Under 45.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10 A.M. ET SUNDAY: BetMGM has the line at Jacksonville -4.5 (-105), almost in line with the -4.5 opener last Sunday. In between, the Jags dipped to -4 Thursday and -3.5 Saturday.

Indianapolis is actually netting 57% of spread bets/59% of spread dollars.

The total climbed from 45.5 to 46.5 Monday, then made its way down to 44 by Friday. It remains 44, with tickets and money 2/1-plus on the Under.

UPDATE 5:30 P.M. ET WEDNESDAY: Jacksonville hit TwinSpires' NFL Week 6 odds board as 4.5-point chalk and is now at -4. The Jags are drawing 64% of early tickets, but 55% of early cash is on the Colts.

"Sharp play on Colts +4.5," TwinSpires' Zachary Lucas said.

The total is down a half-point to 45 at TwinSpires, with 52% of early tickets/59% of early money on the Under.

UPDATE 11 P.M. ET SUNDAY: Jacksonville had a successful two-week run in London, going 2-0 SU and ATS in its home away from home. The Jaguars (3-2 SU and ATS) knocked off Buffalo 25-20 catching 4.5 points in Week 5.

Indianapolis (3-2 SU and ATS) just got star running back Jonathan Taylor under contract, so he didn't play much in Week 5. But teammate Zack Moss went haywire with 23 carries for 165 yards and two TDs. That helped the Colts notch a 23-16 win catching 2.5 points against visiting Tennessee.

However, rookie QB Anthony Richardson left in the second quarter with a shoulder injury.

"The market likes Indianapolis in this spot. Both on the lookahead line and today, we opened this game Jags -5.5, and it has been bet down to -4.5 both times," Michaelson said. "Jonathan Taylor is an awesome player. But it's my opinion that the spot for Jacksonville – flying transatlantic after two weeks in London – is the angle the wiseguys are looking at, more than the return of a running back.

"With the injury concerns at QB in Indy, and the Jaguars looking good this morning, we felt the line should go up. Bettors disagreed."

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 6 Report containing spreads, lines, and trends for every NFL matchup.

Colts vs Jaguars Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction: I've had this spot circled since the schedule came out. The market is moving against us on Sunday morning, with the Colts as low as +3.5 at some books, but you can still get +4.5 at PointsBet.

Make sure to visit our Best NFL Betting Sites page for more NFL coverage.

Pick: Colts +4.5

For more NFL picks, check out Action Network's NFL Week 6: How to Bet Every Game & Every Team.

The One Stat to Know About Colts vs Jaguars

Action Network NFL researcher Evan Abrams offers his top betting stat: Only 11 times in NFL history has a team returned home from Europe without a bye week. Every one of those teams was tied or trailing in the fourth quarter the following week. Opponent team totals are 7-4 to the over. — via Brandon Anderson.

For more NFL betting stats, check out Action Network's NFL Week 6 Betting Trends, Stats, Notes.

Where to place a bet this NFL Season?

• Use our exclusive BetMGM Bonus Code VIBONUS1600 to unlock BetMGM's welcome offer for new sportsbook users!
• Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
• Sports betting is live in North Carolina! Check out our list of North Carolina Sportsbooks and get ready for the NFL season.
• Our DraftKings Promo Code earns users $150 in bonus bets when you bet $5. Sign up today!

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson