NFL Odds Week 6: Giants vs Bills Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

2 minute read

The NFL betting odds see the Bills as heavy 14-point home favorites against the Giants in Week 6 for a primetime showdown. Coverage begins from Highmark Stadium in Orchard Park on Sunday, October 15 at 8:20 p.m. ET on NBC.

Here's everything you need to know about the NFL odds for Week 6 Giants vs Bills: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

New York Giants vs Buffalo Bills Odds

• Opening point spread: Bills -15.5
• Opening moneyline: Bills -1400/Giants +750
• Opening total: Over/Under 46 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

UPDATE 3 P.M. ET FRIDAY: The Bills backed up from -14.5 to -14 Monday at BetMGM, returned to -14.5 Thursday and adjusted to -14.5 (-115) a few hours ago. Buffalo is netting 58% of spread bets, but 62% of spread cash is in big 'dog New York.

The total fell from 46.5 to 44.5 by Tuesday and inched another notch to 44 this afternoon. The Over is landing 62% of bets, but money is running dead even at BetMGM.

UPDATE 11 P.M. ET SUNDAY: Buffalo saw its three-game SU and ATS surge – all blowout victories – end in London against Jacksonville. The Bills (3-2 SU and ATS) mustered just one TD through the first three quarters in coming up short 26-20 as 4.5-point favorites.

New York is now 1-4 SU and an imperfectly perfect 0-5 ATS. And the G-Men are 0-3 SU and ATS in prime time, heading into a Sunday night clash in Buffalo. In Week 5, the Giants lost 31-16 getting 12.5 points at Miami.

"We closed Bills -13 on the looakhead and re-opened -15.5, having since been bet down to -15. That move is likely a result of the Buffalo travel situation, because it isn't anything pro-Giants," Michaelson said. "It's a very low power rating for Big Blue right now. The only reason we are getting any sharp Giants money is Buffalo's travel.

"The spread is probably high enough to scare the public away, but the Giants are going to test that theory."

Later this evening, Buffalo dipped another half-point to -14.5.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 6 Report containing spreads, lines, and trends for every NFL matchup.

Giants vs Bills Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction: Despite all the big Buffalo injuries and a loss, this line has risen three points toward Buffalo. It's just too many points, so I have to play the number. That post-London trends are so strong, telling us the Giants should score more than expected and maybe even lead in the fourth quarter.

Pick: Giants +15.5

For more NFL picks, check out Action Network's NFL Week 6: How to Bet Every Game & Every Team.

The One Stat to Know About Giants vs Bills

Action Network NFL researcher Evan Abrams offers his top betting stat: Only 11 times in NFL history has a team returned home from Europe without a bye week. Every one of those teams was tied or trailing in the fourth quarter the following week. Opponent team totals are 7-4 to the over.

For more NFL betting stats, check out Action Network's NFL Week 6 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson