NFL Odds Week 7: Chargers vs Chiefs Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

Week 7 of the NFL season showcases a huge game in the AFC West as the Chiefs host the Chargers. The odds favor Kansas City by 5.5 points as they seek a 6th straight victory. Catch all the action live from Arrowhead Stadium on Sunday, October 22 at 4:25 p.m. ET on CBS.

Here's everything you need to know about the NFL odds for Week 7 Chargers vs Chiefs: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

Los Angeles Chargers vs Kansas City Chiefs Odds

• Opening point spread: Chiefs -5.5
• Opening moneyline: Chiefs -250/Chargers +200
• Opening total: Over/Under 50.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

UPDATE 3 P.M. ET WEDNESDAY: Kansas City hasn't moved off the -5.5 opener at TwinSpires Sportsbook. The Chiefs are netting 58% of early spread bets/62% of early spread cash.

TwinSpires' total has seen some movement, from 49 to 48. The Over is getting 65% of bets, but 56% of cash is on the Under.

"The public keeps chasing Kansas City Overs each week, which has been great for us," Lucas said. "Sharp play on Under 49."

Kansas City is 4-2 to the Under so far this season.

UPDATE 6 P.M. ET TUESDAY: The Chargers (2-3 SU and ATS) lost to Dallas 20-17 in the Week 6 Monday nighter, failing to cash as 1.5-point home underdogs, as well. That didn't change opinions inside The SuperBook's risk room, as Kansas City remained at the -5.5 opener against L.A. in Week 7.

However, the total is now down 3 points from the opener, to 47.5.

UPDATE 11 P.M. ET SUNDAY: Since a Week 1 home loss to Detroit, Kansas City is on a 5-0 SU/4-1 ATS upswing. In the Week 6 Thursday nighter, it wasn't pretty, but the Chiefs won 19-8 to barely cover the 10.5-point spread.

Los Angeles (2-2 SU and ATS) still has Week 6 work to do, hosting Dallas on Monday night.

"Kansas City has been sleepwalking most of the season, it feels like, and is still winning games – and covering," Michaelson said. "The Chargers play Monday night, so things will change then. But we opened at 5.5 instead of 6 because K.C.'s offense doesn't feel like it's quite clicking the way it's capable of. I would be very surprised if we don't need LA in this game.

"The more important line, of course, is number of times CBS shows Taylor Swift during the broadcast. Right now, we have it set at 5.5 to match the game line."

Michaelson is joking, of course, as Nevada regulations don't allow for such prop bets. But point well taken.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 7 Report containing spreads, lines, and trends for every NFL matchup.

Chargers vs Chiefs Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction: Fine, the Chargers can hang around. They always find a way to stay close. Brandon Staley (9-4 ATS) and Justin Herbert (13-7 ATS) have been profitable as underdogs, and both of them are 67% ATS as division dogs. This year's Chiefs aren't built to blow these Chargers out.

But doesn't it feel like this particular matchup leans Kansas City's way? The Chargers probably can't run on this defense, and Chris Jones should wreak havoc up the middle with Linsley out. LA's pass defense is the weak spot, so Mahomes will find a way, even if it's late and close.

Chargers +5.5 feels like the sharp side the way these games have gone in recent years, but I trust Mahomes to find a way in the end against a Chargers secondary that's been beaten time and again. The line feels about right to me, but if it looks like a one-score Chiefs victory, why not bet on it?

Pick: Chiefs to Win by 1-6 (+300)

For more NFL picks, check out Action Network's NFL Week 7: How to Bet Every Game & Every Team.

The One Stat to Know About Chargers vs Chiefs

Action Network NFL researcher Evan Abrams offers his top betting stat: Justin Herbert is 5-1 ATS vs. Chiefs and 24-24-1 ATS vs. all other teams.

For more NFL betting stats, check out Action Network's NFL Week 7 Betting Trends, Stats, Notes.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson