NFL Odds Week 8: Bengals vs 49ers Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

4 minute read

Week 8 of the NFL season resumes with a marquee non-conference matchup between the Bengals and 49ers. The betting odds see San Francisco as a 5.5-point favorite coming off a head-scratching loss to Minnesota on Monday night. Coverage begins from Levi's Stadium in Santa Clara on Sunday, October 29 at 4:25 p.m. ET on CBS.

Here's everything you need to know about the NFL odds for Week 8 Bengals vs 49ers: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

Cincinnati Bengals vs San Francisco 49ers Odds

• Opening point spread: 49ers -5.5
• Opening moneyline: 49ers -250/Bengals +300
• Opening total: Over/Under 45.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

UPDATE 4 P.M ET WEDNESDAY: This game literally just got a huge jolt, with news in the past 30 minutes of Niners QB Brock Purdy being in concussion protocol. PointsBet reacted swiftly, dropping San Francisco straight from -5.5 to -3.5, then going to -3 (-120) and -3 (-115).

Even before that news broke, opinion was split on this game. The Bengals were drawing 58% of spread bets, while 61% of spread dollars were on the 49ers. San Francisco opened -6 and toggled between -6 and -5.5 a couple times before the Purdy news.

"The Bengals continue to be a mystery for any oddsmaker or handicapper, as their star-studded offense continues to labor its way through the season," Meenan said. "The betting market appeared to give the Bengals the benefit of the doubt through the first few weeks. However, apart from a big day from Ja'Marr Chase against the leaky Cardinals defense, this offense has looked really out of sorts, scraping past Seattle before the bye week.

"Meanwhile, the Niners have crashed back to earth after losing to the Vikings on Monday Night Football, and Brock Purdy finally looks human."

Meenan noted public bettors were on San Fran at -5.5. But things are in limbo at the moment, until there's more clarity on Purdy's status.

PointsBet's total fell from 46 to 45 Tuesday, then this afternoon went to 44 and 43.5 on the Purdy news.

UPDATE 11 P.M. ET SUNDAY: San Francisco (5-1 SU and ATS) still has its Week 7 game to play. The Niners travel to Minnesota for the Monday night game.

Cincinnati (3-3 SU/2-3-1 ATS) is coming off its bye week. The Bengals fended off Seattle 17-13 in Week 6, cashing as 3-point home faves.

The spread and total are stable tonight in The SuperBook's NFL odds Week 8 market.

"Both sides have taken smaller bets, but nothing significant yet," Degnon said. "How the Niners look Monday against the Vikings will help dictate which side draws more interest from the public. Although San Fran at home will be a popular parlay leg all year."

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Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 8 Report containing spreads, lines, and trends for every NFL matchup.

Bengals vs 49ers Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Nothing on paper so far this season says to bet the Bengals. Cincinnati's offense ranks bottom 10 by DVOA both rushing and passing. The run defense has been miserable, a problem against such a creative rushing attack, and the defense has been bad over the middle where San Francisco is so good. Cincinnati's offensive line metrics have been awful, and the defense has struggled on the road. On paper, this is a mismatch.

But the stat sheet doesn't know Joe Burrow like we do.

Including the playoffs, Burrow is 14-2 ATS (88%) lifetime as an underdog of three or more points. Both of those failed covers came his rookie season too, so he's a perfect 9-0 ATS in that spot since then. And he's not just covering. Burrow is 7-2 SU in those games. A $100 bettor that blindly bet Burrow as an underdog of three or more anytime since his rookie season would be up $1,078, an absurd 120% ROI. Burrow hasn't lost by more than a field goal as an underdog in any game since his rookie season, including the playoffs.

But you already know all that. This is Joe Cool. This is what he does. This team lives for these underdog moments. Who Dey!

Pick: Bengals +5.5 (-110) & Bengals ML (+200)

For more NFL picks, check out Action Network's NFL Week 8: How to Bet Every Game & Every Team.

The One Stat to Know About Bengals vs 49ers

Action Network NFL researcher Evan Abrams offers his top betting stat:

Off two straight losses or more, Kyle Shanahan is just 12-12 ATS and 5-4 ATS since 2020.

For more NFL betting stats, check out Action Network's NFL Week 8 Betting Trends, Stats, Notes.

Where to place a bet this NFL Season?

• Use our exclusive BetMGM Bonus Code VIBONUS1600 to unlock BetMGM's welcome offer for new sportsbook users!
• Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson