College Football Odds Week 5: Lines, Betting Trends on Biggest Games

College football odds for Week 5 include the Game of the Year so far. No surprise, it's in the SEC: Georgia Bulldogs vs. Alabama Crimson Tide.

It's a mega-matchup in odds for college football Week 5. The winner takes the inside track in the SEC championship chase and a bye in the College Football Playoff.

Here’s everything you need to know about the college football odds Week 5 market: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on college football Week 5 odds and action. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

College Football Odds for Week 5

Oklahoma State vs. Kansas State Odds

QB Alan Bowman and Oklahoma State hope to pull an upset at Kansas State. (Getty)
Matchup Spread Total Moneyline
Kansas State vs
Oklahoma State
-4.5 (-112)
+4.5 (-108)
o55.5 (-108)
u55.5 (-112)
-192
+160
  • Opening point spread: Kansas State -6
  • Opening moneyline: Kansas State -230/Oklahoma State +185
  • Opening total: Over/Under 54.5 points scored
  • Time: Noon ET Saturday (ESPN)

UPDATE 6 P.M. ET MONDAY: Both these teams lost in Week 4 and can ill afford another setback if they hope to stay in the CFP chase.

No. 20 Oklahoma State (3-1 SU/2-2 ATS) didn't have to face QB Cam Rising in its meeting with then-No. 12 Utah, but it didn't matter. The Cowboys dug themselves into a 22-3 hole with 6:21 remaining in the game, and a late rally fell short in a 22-19 loss as 1-point home favorites.

Meanwhile, No. 23 Kansas State (3-1 SU/1-3 ATS) went to BYU as 7.5-point chalk and got run out of Provo 38-9.

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TwinSpires Sportsbook opened Oklahoma State vs. Kansas State at Wildcats -6, and it's down to -5.5. It's two-way spread play, with 59% of tickets on the Wildcats/55% of money on the Cowboys.

"Sharp play on Oklahoma State +6," TwinSpires director of retail sports Zachary Lucas said, before addressing the total. "The public loves the Over in this spot."

The total hasn't moved off 54.5 in TwinSpires' college football odds Week 5 market. But the Over is landing 67% of early tickets/74% of early money.

Louisville vs. Notre Dame Odds

Matchup Spread Total Moneyline
Notre Dame vs
Louisville
-6 (-112)
+6 (-108)
o45 (-110)
u45 (-110)
-218
+180
  • Opening point spread: Notre Dame -5
  • Opening moneyline: Notre Dame -210/Louisville +170
  • Opening total: Over/Under 48 points scored
  • Time: 3:30 p.m. ET Saturday (Peacock)

UPDATE 6 P.M. ET MONDAY: No. 17 Notre Dame (3-1 SU/2-2 ATS) rebounded from its stunning Week 2 loss to Northern Illinois by posting consecutive blowouts. The Fighting Irish trashed Purdue 66-7 laying 7 points on the road in Week 3, then beat Miami-Ohio 28-3 giving 27.5 points in Week 4.

No. 19 Louisville (3-0 SU and ATS) takes a big step up in class this week, as an underdog for the first time this season. In Week 4, the Cardinals were 8.5-point home favorites vs. Georgia Tech and won 31-19.

TwinSpires Sportsbook opened the Irish -5 and is already out to -6.5, with a stop at -6 along the way. But both sides are seeing action, with 64% of early spread tickets on Louisville/59% of early spread money on Notre Dame.

"With half our books being in Kentucky, we typically see bias toward Louisville. Sharp play came in and grabbed Notre Dame -5. We'll likely see this line go back down, as money will come in on the Cardinals later in the week," TwinSpires director of retail sports Zachary Lucas said.

The total inched from 48 to 47.5 early in TwinSpires' college football week 5 odds. The Under is seeing 58% of tickets/52% of money.

Georgia vs. Alabama Odds

Jalen Milroe and Alabama face a huge test at home vs. Georgia. (Getty)
Matchup Spread Total Moneyline
Alabama vs
Georgia
+2 (-108)
-2 (-112)
o48.5 (-108)
u48.5 (-112)
+110
-130
  • Opening point spread: Georgia -3
  • Opening moneyline: Georgia -135/Alabama +110
  • Opening total: Over/Under 49.5 points scored
  • Time: 7:30 p.m. ET Saturday (ABC)

UPDATE 6 P.M. ET MONDAY: No. 2 Georgia (3-0 SU/1-2 ATS) got perhaps a well-timed early bye in Week 4, after a struggle session in Week 3. The Bulldogs closed as 21.5-point favorites at Kentucky, but narrowly escaped with a 13-12 victory.

On the flip side, No. 4 Alabama has been nothing but impressive while going 3-0 SU/2-1 ATS. The Crimson Tide also had a Week 4 bye, after crushing Wisconsin 42-10 as 14.5-point road favorites in Week 3.

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Georgia vs. Alabama is already on the move in the college football odds Week 5 market at TwinSpires Sportsbook. The Bulldogs opened -3 and made a stop at -2 on the way to -1.5. Georgia is seeing 59% of early spread tickets, while 64% of early spread money is on Alabama.

"Sharp play on Alabama +3 right as we opened," TwinSpires director of retail sports Zachary Lucas said.

The total dipped from 49.5 to 48.5 in the early going, with 57% of tickets/66% of money on the Under.

Illinois vs. Penn State Odds

Matchup Spread Total Moneyline
Penn State vs
Illinois
-18 (-112)
+18 (-108)
o48 (-108)
u48 (-112)
-1000
+650
  • Opening point spread: Penn State -17
  • Opening moneyline: Penn State -955/+585
  • Opening total: Over/Under 48 points scored
  • Time: 7:30 p.m. ET Saturday (NBC)

UPDATE 6 P.M. ET MONDAY: No. 10 Penn State (3-0 SU/2-1 ATS) had all sorts of trouble with Bowling Green in Week 2, escaping with a 34-27 victory as massive 34-point home chalk. The Nittany Lions then had a bye in Week 3, which seemed to right the ship.

In Week 4, Penn State drilled Kent State 56-0 laying 49 points at home.

No. 24 Illinois (4-0 SU/3-0-1 ATS) is perhaps one of the early-season surprises. The Fighting Illini traveled to Nebraska as 9.5-point underdogs in Week 4 and notched a 31-24 overtime victory.

Still, Penn State opened as a healthy 17-point favorite vs. Illinois in TwinSpires Sportsbook's college football Week 5 odds market. And the Nittany Lions are already up a notch to -17.5.

However, Illinois is attracting 75% of early spread tickets/65% of early spread money.

"It feels like everyone is lining up to grab the over-two-touchdown spread in this matchup and taking the 'dog," TwinSpires director of retail sports Zachary Lucas said. "We saw some sharp play on Penn State -17. This could end up being Pros vs. Joes here."

The total nudged from 48 to 47.5 early, but it's now 48.5.

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