St. Louis Cardinals vs. Milwaukee Brewers Picks, Predictions, Odds

St. Louis Cardinals vs. Milwaukee Brewers Betting Analysis

The Cardinals visit the Brewers at American Family Field on Tuesday, September 27, 2022 for the first of a two-game series.

St. Louis leads the National League Central at 89-65, putting together a 38-38 record when playing away from Busch Stadium. The Brewers rank second in the National League Central with a record of 82-71, and 42-30 at home, which trails the first-place Cardinals by 6.5 games.

Updated on 12/23/2024

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St. Louis Cardinals vs. Milwaukee Brewers Betting Prediction

St. Louis enters this matchup atop the NL Central standings with a six and a half game lead over the second place Milwaukee Brewers. With just eight games remaining on their schedule St. Louis is in a great position to win the division as six of those games will be against the Pittsburgh Pirates who have one of the worst records in baseball. The Cardinals most recently went 1-2 SU in a three-game series with the Dodgers and are 5-5 SU over their last 10 games. The offense has been productive throughout the season with a batting average of .253 (10th), on base percentage of .325 (4th), slugging percentage of .422 (6th) and have scored 732 total runs (5th). The bullpen has also been efficient with a WHIP of 1.26 (5th) and team ERA of 3.77 (9th). The right-hander Miles Mikolas (11-13, 3.35 ERA) is scheduled to start Tuesday.  

This two-game series against St. Louis is huge for the Brewers as they sit six and a half games behind the Cardinals for lead of the NL Central. The Brewers are also in contention for a Wild Card berth, back a game and a half from the Phillies for the third spot. Milwaukee went 3-1 SU in their most recent series against Cincinnati and have won six of their last 10 games. Their offense has been consistent for the most part this season with a batting average of .235 (22nd), on base percentage of .316 (13th), slugging percentage of .411 (8th) and have scored 698 total runs (9th). Milwaukee’s bullpen has had their difficulties this season but have still pitched well overall with a WHIP of 1.23 (10th) and team ERA of 3.90 (13th). Right-handed pitcher Adrian Houser is expected to start for the Brewers on Tuesday.  

I like the Cardinals to take game-one of this series. Miles Mikolas has not been great this season but has been pitching well enough as of late to trust here. Houser has struggled throughout the season for the Brewers and I expect that to be the case on Tuesday as well. Not to mention, a win for St. Louis and they clinch the division. Backing the Cardinals moneyline here.  

Score Prediction: Cardinals 5, Brewers 3
Best Bet: Cardinals (-115)

St. Louis Cardinals vs. Milwaukee Brewers Betting Odds

St. Louis Cardinals vs. Milwaukee Brewers Betting Resources

• Date: Tuesday, September 27, 2022
• Matchup: NL Central
• Venue: American Family Field
• Location: Milwaukee, Wisconsin
• Time-TV: 7:40 p.m. ET – MLB Network
• Expert Picks

St. Louis Cardinals vs. Milwaukee Brewers – Current Form

St. Louis has suffered two straight series losses, falling to the Padres and the Dodgers. They kept the Los Angeles Dodgers from scoring any runs in the first contest of the series on Friday. The Brewers lost 2-1 against the Mets last Wednesday, but then went 1-2 to the Reds in their next game on Sunday. The Mets were unable to score a single run against the Milwaukee Brewers on Wednesday, which was Milwaukee’s best result in the last two series.

St. Louis Cardinals vs. Milwaukee Brewers – Pitching Matchup

St. Louis: Miles Mikolas (11-13, 3.35 ERA)

Miles Mikolas is on the hill for the Cardinals in this contest as he makes his 31st start of the season hoping to build some positive momentum. He comes in 11-13 with a 3.35 ERA, a 1.04 WHIP, 38 walks and 144 strikeouts over 193.1 innings of work this season. The 34-year-old right-hander couldn’t lift the Cardinals to win on the road over the San Diego Padres on September 21, 2022. In his losing start, Mikolas tossed six innings in the 1-0 defeat by San Diego Padres, while giving up one run on three hits with six strikeouts and two walks. Mikolas owns a 5-10 road record this season in 17 starts away from Busch Stadium. In those away outings, he has posted a 4.29 ERA, a 1.24 WHIP, 23 walks, and 75 strikeouts in 98.2 innings of work.

Milwaukee: Adrian Houser (6-9, 4.62 ERA)

The Brewers’ right-hander Adrian Houser owns a 6-9 record and 4.62 ERA in his 20th start of the season. Houser also posted a 1.45 WHIP, while striking out 66 and walking 43 batters in 99.1 innings this season. Milwaukee’s 29-year-old right-hander didn’t factor in the decision in his last start, which came at home against the New York Mets September 21, 2022. He threw 4.2 innings, on three hits in a 6-0 Brewers loss. Houser owns a 3-4 home record this season in 10 starts at the American Family Field. In those outings, he has posted a 3.42 ERA, a 1.26 WHIP, 20 walks, and 38 strikeouts in 55.1 innings of work.

St. Louis Cardinals vs. Milwaukee Brewers – Series History

St. Louis had a great 2021 season in this matchup, tallying a 11-8 mark. St. Louis has scooped up victories in nine of the 17 encounters between the pair.