NFL Odds Week 16: Lines, Spreads, Betting Trends For All 16 Games

Patrick Everson Sports Betting Expert

16 minute read

2024 NFL Odds Week 16

NFL odds for Week 16 bring Saturday games into the mix for the first time this season. Which means Christmas must be near.

Both matchups are noteworthy in odds for NFL Week 16: Houston Texans vs. Kansas City Chiefs – perhaps minus Patrick Mahomes – and Pittsburgh Steelers vs. Baltimore Ravens.

Here’s everything you need to know about the NFL odds Week 16 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on Week 16 NFL odds and action. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

NFL Odds for Every Game of NFL Week 16

Denver Broncos vs. Los Angeles Chargers Odds

• Opening point spread: Chargers -3
• Opening moneyline: Chargers -160/Broncos +140
• Opening total: Over/Under 42 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

UPDATE 10:30 P.M. ET SUNDAY: Denver (9-5 SU/11-3 ATS) didn't do much at all through three quarters against Indianapolis, managing just 10 points while trailing 13-10. But the Broncos put up three TDs in the fourth quarter en route to a 31-13 victory giving 4.5 points at home.

To be fair, Denver was quite fortunate. Early in the third quarter, Jonathan Taylor was running in for a touchdown that would've put the Colts up 20-7. But he let go of the ball before he crossed the goal line, and the ball rolled out of bounds in the end zone for a touchback.

The Broncos also got a defensive touchdown early in the fourth quarter. Denver is 6-2 SU/7-1 ATS in its last eight games and has the best overall ATS record in the NFL.

Los Angeles (8-6 SU/9-5 ATS) had a surprising outcome in Week 15. The Chargers led Tampa Bay 17-13 at halftime, but got shut out the rest of the way while allowing 27 unanswered points. L.A. lost 40-17 as 3-point home favorites.

The SuperBook opened Broncos-Chargers at L.A. -3, with no movement so far tonight in Week 16 NFL odds.

"Chargers -3 at home, in a stadium that I’m assuming will be packed with Broncos fans on Thursday night," SuperBook vice president John Murray said. "This should be a solid game between two teams heading to the playoffs. We haven't seen much yet, but I would expect good two-way handle."

Houston Texas vs. Kansas City Chiefs Odds

• Opening point spread: Texans -2.5
• Opening moneyline: Texans -135/Chiefs +115
• Opening total: Over/Under 40 points scored
• Time: 1 p.m. ET Saturday (NBC)

UPDATE 10:30 P.M. ET SUNDAY: Kansas City (13-1 SU/6-8 ATS) finally avoided a close game and snapped a seven-game spread-covering slide in the process. The Chiefs coasted past Cleveland 21-7 as 4-point road favorites.

However, K.C. didn't avoid a key injury. QB Patrick Mahomes left midway through the fourth quarter after hurting his right ankle.

Houston (8-6 SU/6-8 ATS) followed a 1-3 SU skid by winning three of its last four. In Week 15, the Texans topped Miami 20-12 giving 2.5 points at home.

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With Mahomes' status uncertain, The SuperBook actually opened Houston as 2.5-point road chalk in the NFL odds Week 16 market. That's a big shift from last week's lookahead line of Kansas City -3.5.

"I’m sure this will be the most talked-about game all week, with the status of Patrick Mahomes the key talking point," SuperBook vice president John Murray said. "Obviously, the line is saying we don’t think Mahomes plays, or at the very least won’t be fully healthy.

"With the Chiefs sitting at 13-1, it doesn’t make much sense to play him if he is hurt. They have been winning with their defense anyway. Getting Mahomes healthy and ready for January is all that matters to Kansas City."

The total opened at 40 and climbed to 41 within a few minutes tonight.

Pittsburgh Steelers vs. Baltimore Ravens Odds

• Opening point spread: Ravens -6.5
• Opening moneyline: Ravens -275/Steelers +235
• Opening total: Over/Under 46.5 points scored
• Time: 4:30 p.m. ET Saturday (FOX)

UPDATE 10:30 P.M. ET SUNDAY: Pittsburgh (10-4 SU and ATS) had its 7-1 SU and ATS run end in Week 15 at Philadelphia. The Steelers closed as 5.5-point underdogs and lost 27-13, failing to score in the second half.

Pittsburgh star linebacker T.J. Watt suffered an ankle injury, and is questionable for Saturday's game.

Meanwhile, after losing two of its last three games, Baltimore (9-5 SU/7-6-1 ATS) got right against the dreadful New York Giants. The Ravens rolled to a 35-14 victory laying a hefty 16.5 points on the road.

Baltimore opened -6.5 vs. Pittsburgh in The SuperBook's NFL Week 16 odds. The Ravens moved to -7 within a few minutes, then fell back to -6.5 an hour later this evening.

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"We took a few hits on the Steelers +7 and moved to +6.5," SuperBook vice president John Murray said. "Baltimore had essentially a bye today against the Giants to tune them up for this game.

"This should be a heavy-handle game in the afternoon on Saturday. Lots of Ravens moneyline parlay and teaser bets."

The total mirrored the spread tonight in going from 46.5 to 47 and back to 46.5.

Philadelphia Eagles vs. Washington Commanders Odds

• Opening point spread: Eagles -3.5
• Opening moneyline: Eagles -180/Commanders +160
• Opening total: Over/Under 47 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10:30 P.M. ET SUNDAY: Philadelphia (12-2 SU/9-5 ATS) is the hottest team in the NFL at the moment, riding a 10-game win streak (7-3 ATS). In Week 15, the Eagles led Pittsburgh 17-13 at the half and didn't allow another point, winning 27-13 as 5.5-point home favorites.

Washington (9-5 SU/8-5-1 ATS) squeaked out of New Orleans with a win, but failed to cover the 7.5-point spread. The Commanders gave up a touchdown as time expired, trimming their lead to 20-19. But Washington stopped the 2-point attempt to secure the victory.

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Philly opened -3.5 tonight and moved to -4 at The SuperBook. The total went the other direction, from 47 to 46.5/46.

"Both teams look to be headed to the playoffs, and the Eagles are suddenly in the mix for the No. 1 seed," SuperBook vice president John Murray said. "Philly and Tampa are probably going to be the two must public sides next weekend. I’m guessing we’ll be rooting for the artist formerly known as Football Team."

New England Patriots vs. Buffalo Bills Odds

• Opening point spread: Bills -13.5
• Opening moneyline: Bills -1200/Patriots +750
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10:30 P.M. ET SUNDAY: Buffalo (11-3 SU/9-5 ATS) put up a mountain of points to knock off Detroit 48-42, ending the Lions' SU win streak at 11. The Bills cashed as 2.5-point road 'dogs and are now 8-1 SU/7-2 ATS in their last nine games.

New England (3-11 SU/5-8-1 ATS) brings a four-game losing streak into Week 16. The Patriots lost to Arizona 30-17 as 6-point road pups in Week 15.

Buffalo hit The SuperBook's NFL Week 16 odds at -13.5 and is already -14. The total was a bit volatile early, dropping from 46.5 to 46/45/44.5, then rebounding to 45/46.

Detroit Lions vs. Chicago Bears Odds

• Opening point spread: Lions -7
• Opening moneyline: Lions -350/Bears +290
• Opening total: Over/Under 47 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 11:30 P.M. ET MONDAY: Chicago (4-10 SU/7-6-1 ATS) was in one of two Week 15 Monday night games, and it didn't go well. The Bears lost at Minnesota 30-12 as 7-point road pups. Chicago is on an eight-game losing skid (2-5-1 ATS).

DraftKings Sportsbook opened Detroit -7.5 vs. Chicago in NFL Week 16 odds. However, earlier today, it was announced that Lions running back David Montgomery will have surgery on a torn MCL, and his season is over.

The Lions are now -6.5 while taking 84% of early spread tickets, but just 60% of early spread money.

The total didn't shift much, from 46.5 to 47 and back to 46.5, with 75% of tickets on the Over/63% of money on the Under.

UPDATE 10:30 P.M. ET SUNDAY: Detroit (12-2 SU/9-4-1 ATS) finally cooled off after posting 11 consecutive victories (8-3 ATS). The Lions couldn't keep up at home in a shootout with Buffalo, losing 48-42 as 2.5-point favorites.

Chicago (4-9 SU/7-5-1 ATS) still has Week 15 work to do, playing at Minnesota on Monday night.

The Lions opened as 7-point favorites vs. the Bears in The SuperBook's NFL odds Week 16 market. There's been no movement tonight.

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"The Lions' offense continues to fire on all cylinders. But their defensive issues should be very concerning for Detroit fans," SuperBook vice president John Murray said. "Chicago will come into this game off a short week, but the Bears nearly beat Detroit on the road on Thanksgiving.

"And the Bears and will have home-field advantage here – Jared Goff outdoors in the cold. I think Detroit will be a public side, but probably not to the level of the Eagles and Bucs."

Los Angeles Rams vs. New York Jets Odds

• Opening point spread: Rams -3
• Opening moneyline: Rams -160/Jets +140
• Opening total: Over/Under 47 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10:30 P.M. ET SUNDAY: Los Angeles (8-6 SU/7-7 ATS) is making a push for the NFC West title. The Rams have won three in a row and are 7-2 SU/6-3 ATS in their last nine games.

In Week 15, L.A. mustered just four field goals at San Francisco. Yet that was enough for a 12-6 Rams win as 3-point road underdogs in the Thursday night game.

New York (4-10 SU/5-9 ATS) halted a four-game skid that was part of a 1-9 SU nosedive overall. A 1-yard Bryce Hall TD run with 1:05 remaining gave the Jets a 32-25 win as 3.5-point favorites at Jacksonville.

Los Angeles is stable tonight as 3-point chalk in The SuperBook's Week 16 NFL odds.

Arizona Cardinals vs. Carolina Panthers Odds

• Opening point spread: Cardinals -3.5
• Opening moneyline: Cardinals -210/Panthers +180
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10:30 P.M. ET SUNDAY: Arizona (7-7 SU/9-5 ATS) halted a three-game skid to stay in the mix in the NFC West. The Cardinals coasted past New England 30-17 giving 6 points at home.

Carolina (3-11 SU/6-8 ATS) was favored for the first time in forever, and it didn't go well. The Panthers were laying 2.5 points at home and lost to Dallas 30-14.

The Cards opened -3.5 and quickly went to -4 tonight at The SuperBook.

Cleveland Browns vs. Cincinnati Bengals Odds

• Opening point spread: Bengals -7
• Opening moneyline: Bengals -330/Browns +260
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10:30 P.M. ET SUNDAY: Cincinnati (6-8 SU/8-6 ATS) won and cashed for the second straight week, keeping alive very slim playoff hopes. The Bengals beat Tennessee 37-27 as 6-point road favorites.

Cleveland (3-11 SU/4-10 ATS) lost its third in a row in what's become a long season. The Browns couldn't get on track against Kansas City, losing 21-7 as 4-point home pups.

Cincinnati keeps being favored more like a winning team than one that remains sub-.500. The SuperBook opened Browns-Bengals at Cincy -7, with no movement tonight in NFL odds Week 16 market.

Tennessee Titans vs. Indianapolis Colts Odds

• Opening point spread: Colts -4.5
• Opening moneyline: Colts -215/ Titans +185
• Opening total: Over/Under 43 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10:30 P.M. ET SUNDAY: Indianapolis (6-8 SU/8-6 ATS) kept Denver in line for three quarters, holding a 13-10 lead. But the Colts shot themselves in the foot while giving gave up 21 unanswered points in the fourth quarter. Indy lost 31-13 getting 4.5 points on the road.

Jonathan Taylor was practically in the end zone on a 41-yard touchdown run that would've put the Colts up 20-7 early in the third quarter. But he let go of the ball just before he crossed the goal line. The ball rolled out of bounds in the end zone for a touchback.

Indy also had a trick play go totally awry in the fourth quarter, leading to a Broncos defensive TD.

Tennessee (3-11 SU/2-12 ATS) is on slides of 1-5 SU and 1-9 ATS. In Week 15, the Titans led Cincinnati 14-7 well into the second quarter. But Tennessee gave up the next 24 points and lost 37-27 getting 6 points at home.

Indy is steady tonight at -4.5 in The SuperBook's Week 16 NFL odds.

New York Giants vs. Atlanta Falcons Odds

• Opening point spread: Falcons -10
• Opening moneyline: Falcons -500/Giants +400
• Opening total: Over/Under 42 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 9 P.M. ET TUESDAY: The Falcons just announced the benching of uber-expensive offseason acquisition Kirk Cousins. Rookie first-round pick Michael Penix Jr. will start at quarterback Sunday at home against the Giants.

However, The SuperBook thought ostensibly nothing of the change. The Falcons were -9 before the Penix move and remain -9 tonight.

"It's not really anything significant here. We're in no rush to move the line down against this current Giants team," SuperBook risk manager Casey Degnon said.

That said, The SuperBook lowered the total from 41.5 to 40.5.

UPDATE 11:30 P.M. ET MONDAY: Atlanta (7-7 SU/6-8 ATS) didn't look all that great Monday night in Las Vegas. But the Falcons scratched out a 15-9 victory laying 6.5 points, snapping a four-game SU and ATS slide.

DraftKings opened Giants-Falcons at Atlanta -9.5 and is now -10. The Falcons are seeing 60% of early spread tickets/83% of early spread money.

DK's total opened at 42.5 and nudged to 43 this morning, though 53% of tickets/61% of dollars are on the Under.

UPDATE 10:30 P.M. ET SUNDAY: New York (2-12 SU/4-10 ATS) hasn't won a game since Week 5, going 0-9 SU/1-8 ATS. In Week 15, the Giants were catching a healthy 16.5 points vs. visiting Baltimore and lost 35-14.

Atlanta (6-7 SU/5-8 ATS) isn't yet out of Week 15, visiting Las Vegas on Monday night.

The SuperBook opened Giants-Falcons at Atlanta -10 in NFL Week 16 odds, with no movement tonight. The total quickly moved from 42 to 42.5.

Minnesota Vikings vs. Seattle Seahawks Odds

• Opening point spread: Vikings -1.5
• Opening moneyline: Vikings -200/Seahawks +175
• Opening total: Over/Under 45.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

UPDATE 11:15 P.M. ET MONDAY: Minnesota (12-2 SU/9-4-1 ATS) had little trouble with Chicago in a Week 15 Monday night game. The Vikings rolled to a 30-12 victory as 7-point home favorites. Sam Darnold & Co. are on a seven-game win streak (4-2-1 ATS).

DraftKings Sportsbook opened the Vikes -2.5, but that was before Sunday night's Packers-Seahawks game, in which Seattle QB Geno Smith suffered a right knee injury.

That led DK to move Minnesota out to -4.5 late Sunday night in Week 16 NFL odds. However, news on Smith earlier this evening was at least semi-positive, and the line shortened to Vikings -2.5 (-115).

It's now Minnesota -3, with 78% of early spread bets on the Vikes and early spread money running almost dead even.

The total opened at 45, tumbled to 41.5 after the Smith injury, and it's now at 42. The Over is seeing 64% of bets, while 73% of money is on the Under.

UPDATE 10:30 P.M. ET SUNDAY: Seattle (8-6 SU/6-7-1 ATS) got rolled by Green Bay 30-13 catching 3 points in the Week 15 Sunday nighter. Making matters worse, quarterback Geno Smith left with a knee injury in the third quarter.

Minnesota (11-2 SU/8-4-1 ATS) has work to finish in Week 15. The Vikings host Chicago on Monday night.

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Minnesota opened -1.5 tonight at The SuperBook. But Vikings-Seahawks was taken off the board once Packers-Seahawks kicked off. Vikes-Seahawks will go back up Monday morning.

"Seattle got beat and has a QB injury to deal with. Talk about a game with a lot of unknowns," SuperBook vice president John Murray said.

San Francisco 49ers vs. Miami Dolphins Odds

• Opening point spread: Dolphins -2.5
• Opening moneyline: Dolphins -135/49ers +115
• Opening total: Over/Under 48 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

UPDATE 10:30 P.M. ET SUNDAY: Miami (6-8 SU and ATS) is in a three-game ATS rut entering Week 16. The Dolphins couldn't muster a TD in Week 16 until just 4:30 remained, losing at Houston 20-12 as 2.5-point pups.

San Francisco (6-8 SU/5-9 ATS) had a miserable Thursday night experience in Week 15. The Niners managed just two field goals the entire game and lost 12-6 as 3-point home favorites vs. the L.A. Rams. In fact, all 18 points came from kickers, as the Rams booted four field goals.

49ers-Dolphins opened Miami -2.5 in The SuperBook's NFL Week 16 odds, with no movement so far. However, the total dipping 2 points in the first 30 minutes, from 48 to 47.5/47/46.

Jacksonville Jaguars vs. Las Vegas Raiders Odds

• Opening point spread: Raiders -1
• Opening moneyline: Raiders -115/Jaguars -105
• Opening total: Over/Under 39.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

UPDATE 11:30 P.M. ET MONDAY: Las Vegas (2-12 SU/5-9 ATS) continues to struggle, taking an 0-10 SU nosedive into Week 16. In a Week 15 Monday night game, the Raiders lost to Atlanta 15-9, but covered as 6.5-point home 'dogs.

Las Vegas opened and remains -1 vs. Jacksonville in DraftKings' NFL odds Week 16 market. The Raiders are getting 53% of early spread bets, while 60% of early spread money is on the Jaguars.

The total opened at 39.5 and is now 40, with the Over netting 58% of bets/57% of money.

UPDATE 10:30 P.M. ET SUNDAY: Jacksonville (3-11 SU/8-6 ATS) had a chance to win two in a row for the first time this season, but couldn't get there in Week 15. The Jags gave up a New York Jets TD with 1:05 remaining and lost 32-25 as 3.5-point home underdogs.

Las Vegas (2-11 SU/4-9 ATS) still has to play in Week 15, hosting Atlanta on Monday night.

The spread and total are stable tonight in The SuperBook's NFL odds Week 16 market, at Raiders -1/39.5.

Tampa Bay Buccaneers vs. Dallas Cowboys Odds

• Opening point spread: Buccaneers -4
• Opening moneyline: Buccaneers -210/Cowboys +180
• Opening total: Over/Under 47.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

UPDATE 10:30 P.M. ET SUNDAY: Tampa Bay (8-6 SU/9-5 ATS) trailed the L.A. Chargers 17-13 at halftime. But the Bucs pitched a 27-0 shutout in the second half, rolling to a 40-17 victory as 3-point road underdogs.

Dallas (6-8 SU and ATS) has won and cashed in three of its last four outings. In Week 15, the Cowboys were 2.5-point pups at Carolina and won 30-14.

The SuperBook toggled between Bucs -4/-3.5 a couple times tonight before settling at -4. The total climbed from 47.5 to 48/48.5.

"Great win for the Bucs and Baker Mayfield today in L.A.," SuperBook vice president John Murray said. "I think this will be a game that the weekend action piles into for the books.

"You’ve got a big favorite Friday night in the College Football Playoff, three more [playoff games] Saturday, and a full slate of NFL games."

To Murray's point: Notre Dame (-7.5) opens the CFP vs. Indiana, followed on Saturday by SMU vs. Penn State (-9); Clemson vs. Texas (-11.5); and Tennessee vs. Ohio State (-7.5).

"A lot of public parlays will be closing with the Bays: Tampa and Green. I don’t see how the Saints can win at Lambeau, so go Cowboys."

New Orleans Saints vs. Green Bay Packers Odds

• Opening point spread: Packers -13.5
• Opening moneyline: Packers -900/Saints +600
• Opening total: Over/Under 43 points scored
• Time: 8:15 p.m. ET Monday (ESPN)

UPDATE 10:30 P.M. ET SUNDAY: Green Bay (10-4 SU/8-6 ATS) rebounded nicely from its Week 14 loss at Detroit. The Packers dispatched Seattle 30-13 giving 3 points on the road. Jordan Love & Co. are 8-2 SU in their last 10 games, covering in the last four.

New Orleans (5-9 SU and ATS) had its modest 3-1 SU upswing end in Week 15, but just barely. The Saints scored a TD on the final play of the game vs. Washington. But New Orleans failed on the 2-point conversion and lost 20-19 catching 7.5 points at home.

Saints-Packers opened at Green Bay -13.5 in The SuperBook's Week 16 NFL odds. The game came off the board once Packers-Seahawks kickoed off. Saints-Packers will go back up Monday morning.

"They don’t do flex games for Monday Night Football any more? This is a ridiculous game to have in prime time," SuperBook vice president John Murray said.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson