NFL Odds Week 4: Lines, Spreads, Betting Trends For Every Game

Patrick Everson Sports Betting Expert

19 minute read

NFL Odds Week 4

NFL odds for Week 4 again include a Monday night sort-of doubleheader, as the games overlap. But the more interesting matchups take place on Sunday.

The best of the bunch in odds for NFL Week 4: the Baltimore Ravens host the Buffalo Bills on Sunday night. And the Philadelphia Eagles visit the Tampa Bay Buccaneers, a rematch from last season's playoffs.

Here’s everything you need to know about the NFL odds Week 4 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 4 odds and action. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.

NFL Odds for Every Game of NFL Week 4

Dallas Cowboys vs New York Giants Odds

• Opening point spread: Cowboys -4.5
• Opening moneyline: Cowboys -200/Giants +175
• Opening total: Over/Under 44 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

UPDATE 3:30 P.M. ET WEDNESDAY: A day out from this NFC East clash, the Cowboys are -5.5 (-115) in Caesars Sports' NFL odds Week 4 market. Dallas opened -5.5 flat Sunday evening, but fell back to -5/-4.5 within a couple hours, then touched -4 Monday morning.

The Cowboys quickly rebounded to -4.5, then Tuesday went to -5.5 (-115).

"We've seen that number drift up to 5.5, aiming toward the 6," Caesars Sports head of football trading Joey Feazel said. "The Cowboys' backs are against the wall, and I think they're desperate. We're seeing a lot of Cowboys money. This could get to 6.5 by Thursday night."

Caesars' total has been on the rise since Sunday evening, from 43.5 to 44 Sunday night, then 45 Tuesday and 45.5 this afternoon.

UPDATE 10 P.M. ET SUNDAY: Dallas (1-2 SU and ATS) got beat up at home for the second straight week – or at least for a good chunk of Sunday's game vs. Baltimore. The Cowboys were 1.5-point underdogs and trailed 28-6 well into the fourth quarter.

Dak Prescott & Co. then put up three touchdowns, but fell short 28-25.

New York (1-2 SU and ATS) pulled off one of a few Week 3 surprises. The Giants went to Cleveland as 6.5-point underdogs and exited with a 21-15 victory.

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The SuperBook opened the Cowboys -4.5 tonight in odds for NFL Week 4. Dallas quickly advanced to -5.5, then backed up to -5/-4.5 again. SuperBook risk supervisor Chase Michaelson is wholly unimpressed with the Pokes.

"Yuck from Dallas," he said. "The Giants have looked competent in back-to-back weeks, and they'll be at home, though I'm not sure if that's a good thing.

"After Week 1, this would've been between Cowboys -7 and -10. Now, I'm sure we'll see some public support for the Giants. I'm sure we'll still need the Giants, but it won't be lopsided like it could have been."

The total nudged around early, too, from 44 to 43.5 and back to 44.

Philadelphia Eagles vs Tampa Bay Buccaneers Odds

• Opening point spread: Eagles -1.5
• Opening moneyline: Eagles -135/Buccaneers +115
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10 P.M. ET SUNDAY: Tampa Bay (2-1 SU and ATS) had a solid first two weeks. Week 3, not so much. The Bucs were laying 6 points at home against a previously unimpressive Denver outfit. But Baker Mayfield & Co. got rolled 26-7.

Philadelphia (2-1 SU and ATS) bounced back from a surprise Week 2 Monday night home loss to Atlanta. But it took almost every minute in an offensive slog at New Orleans.

The Eagles gave up a touchdown with 2:03 remaining to fall behind 12-7. However, Philly followed with a TD drive of its own, as Saquon Barkley scored with 1:01 remaining to give the Eagles a 15-12 win as 2.5-point underdogs.

Philadelphia opened -1.5 in The SuperBook's NFL odds Week 4 market. That number quickly moved out to Eagles -2.5 tonight.

"We opened 1.5 and got some early Philly money," SuperBook risk supervisor Chase Michaelson said. "It'll be interesting to see how this develops during the week, since Tampa didn't look good at all this week and Philly survived a really tough game in New Orleans.

"The last time these teams played in this stadium, it didn't go well for the Eagles."

Indeed, Tampa drilled Philly 32-9 in the NFC Wild Card Round last season.

New Orleans Saints vs Atlanta Falcons Odds

• Opening point spread: Pick
• Opening moneyline: Falcons -120/Saints even
• Opening total: Over/Under 45.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10 P.M. ET SUNDAY: New Orleans (2-1 SU and ATS) was a scoring machine in Weeks 1 and 2, totaling 91 points. There was no such outburst in Week 3.

The Saints got a touchdown with 2:03 remaining to take a 12-7 lead over Philadelphia. But New Orleans, 2.5-point home chalk, then allowed a speedy Eagles TD drive and lost 15-12.

Atlanta (1-2 SU and ATS) gave Kansas City a good test, but couldn't get the job done at home in the Week 3 Sunday night game. The Falcons lost 22-17, with their final two drives in the fourth quarter stalling in the red zone. Atlanta was a 3-point underdog.

Neither the opening Saints-Falcons spread of pick 'em nor opening total of 45.5 moved early at The SuperBook. Saints-Falcons came off the board once Chiefs-Falcons kicked off. Saints-Falcons will go back up Monday morning.

"The Saints had another good performance defensively, but the offense didn't come along for the ride," SuperBook risk supervisor Chase Michaelson said. "Through three weeks, it's clear that the Saints are good enough to hang with anyone."

Minnesota Vikings vs Green Bay Packers Odds

• Opening point spread: Packers -2.5
• Opening moneyline: Packers -140/Vikings +120
• Opening total: Over/Under 43.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10 P.M. ET SUNDAY: Green Bay (2-1 SU and ATS) is 2-0 SU and ATS without injured starting QB Jordan Love. With Malik Willis at the help, the Packers topped Tennessee 30-14 catching 3 points on the road.

Minnesota (3-0 SU and ATS) had an even easier time with a highly touted Houston squad. The Vikings rumbled to a 34-7 victory getting 1.5 points at home.

The SuperBook opened Vikings-Packers at Green Bay -2.5 tonight and hasn't moved in NFL Week 4 odds.

"Who would've predicted Malik Willis would go 2-0 as the starter?" SuperBook risk supervisor Chase Michaelson said. "We expect Jordan Love back, which is why Green Bay is favored. But this is another game I expect two-way action on. Minnesota has looked so good thus far."

The total inched from 43.5 to 43 tonight.

Denver Broncos vs New York Jets Odds

• Opening point spread: Jets -7.5
• Opening moneyline: Jets -350/Broncos +270
• Opening total: Over/Under 38.5points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10 P.M. ET SUNDAY: New York (2-1 SU and ATS) won and cashed in its last two outings, following a season-opening loss at San Francisco. In the Week 3 Thursday nighter, the Jets plowed over New England 24-3 laying 6.5 points at home.

New York now has the benefit of a mini-bye, getting a couple extra days to rest.

Denver (1-2 SU and ATS) got rookie QB Bo Nix his first win in unexpected fashion. Facing a Tampa Bay team that beat Detroit on the road in Week 2, the Broncos breezed to a 26-7 victory as 6-point road underdogs.

Still, The SuperBook opened Jets-Broncos at New York -7.5 and briefly went to -8 tonight, before returning to -7.5.

Jacksonville Jaguars vs Houston Texans Odds

• Opening point spread: Texans -4
• Opening moneyline: Texans -215/Jaguars +185
• Opening total: Over/Under 45 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 1:30 P.M. ET TUESDAY: Trevor Lawrence and Jacksonville had nothing in the tank in a Week 3 Monday night game at Buffalo. The Jags were 4.5-point underdogs and trailed 34-3 at halftime en route to a 47-10 wipeout.

During that blowout loss, The SuperBook took this week's Jags-Texans game off the board, with a line of Houston -4.5. This morning, Jags-Texans went back up with Houston at -6, and it's now -6.5.

UPDATE 10 P.M. ET SUNDAY: Houston (2-1 SU/0-3 ATS) went to Minnesota as a modest 1.5-point chalk and got rocked. C.J. Stroud had two interceptions, and the Texans managed only a late-third-quarter touchdown in a 34-7 road loss.

Jacksonville (0-2 SU/1-1 ATS) still has Week 3 work to do. The Jags visit the Buffalo Bills on Monday night.

Houston opened and remains -4 in The SuperBook's NFL odds Week 4 market.

Cincinnati Bengals vs Carolina Panthers Odds

• Opening point spread: Bengals -6
• Opening moneyline: Bengals -240/Panthers +200
• Opening total: Over/Under 44 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 11 P.M. ET MONDAY: Cincinnati (0-3 SU/1-2 ATS) might already be in a hole it can get out of, after an upset home loss in Week 3. The Bengals closed as 7.5-point favorites in a Monday night game against Washington, and they lost 38-33.

In response, DraftKings Sportsbook reopened Bengals-Panthers tonight at Cincinnati -4.5. The Bengals initially opened -6.5 Sunday night and quickly dipped to -6/-5.5, then went to -5 Monday morning.

At this moment, DraftKings is seeing 70% of early spread bets and 67% of early spread money on the Bengals. But with Carolina overperforming in a Week 3 win at Las Vegas – with former Cincy QB Andy Dalton now at the helm – the Panthers could get more interest as the week goes on.

UPDATE 10 P.M. ET SUNDAY: Carolina (1-2 SU and ATS) went 0-2 SU and ATS in the first two weeks, by a combined total score of 73-13. Then the Panthers benched Bryce Young and brought in Andy Dalton.

The result was stunning. Carolina went to Las Vegas as a 5.5-point underdog and left the Strip with a stunning 36-22 victory. And it wasn't really that close, as the Panthers led 33-7 early in the fourth quarter.

Cincinnati (0-2 SU/1-1 ATS) still has its Week 3 game to play. The Bengals host Washington on Monday night.

The SuperBook opened Bengals-Panthers at Cincy -6. That line is stable, but the total advanced from 44 to 44.5/45.5 tonight.

Los Angeles Rams vs Chicago Bears Odds

• Opening point spread: Bears -2.5
• Opening moneyline: Bears -140/Rams +120
• Opening total: Over/Under 41 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 10 P.M. ET SUNDAY: Chicago (1-2 SU/2-1 ATS) fell to Indianapolis 21-16 as a 2.5-point road underdog. Caleb Williams had big stats – 33 of 52 for 363 yards – but the Bears played from behind the entire way, with Williams' two TD passes coming in the fourth quarter.

Williams also threw two interceptions.

Los Angeles (1-2 SU and ATS) won the game it was most expected to lose in these first three weeks. The Rams, down wideouts Puka Nacua and Cooper Kupp, stunned San Francisco 27-24 as 6-point home underdogs.

L.A. rallied from a 21-7 third-quarter deficit, winning on a Joshua Karty final-seconds field goal.

Rams-Bears opened at Chicago -2.5 and in short order dropped straight to -1 in The SuperBook's NFL odds Week 1 market. The total dipped from 41 to 40 tonight.

Pittsburgh Steelers vs Indianapolis Colts Odds

• Opening point spread: Steelers -1
• Opening moneyline: Steelers -125/Colts +105
• Opening total: Over/Under 39 points scored
• Time: 1 p.m. ET Sunday (CBS)

UPDATE 10 P.M. ET SUNDAY: Pittsburgh is surprisingly out to a 3-0 SU and ATS start. In Week 3, the Steelers topped the L.A. Chargers 20-10 laying 2.5 points at home.

Indianapolis (1-2 SU/2-1 ATS) cracked the win column in Week 3. The Colts held off Chicago 21-16 giving 2 points at home.

Early Week 4 bettors seem to be believers in the Steelers. The SuperBook opened Pittsburgh -1 and went to -1.5/-2 tonight. The total is dipped from 39.5 to 39/38.5.

Washington Commanders vs Arizona Cardinals Odds

• Opening point spread: Cardinals -6
• Opening moneyline: Cardinals -250/Commanders +210
• Opening total: Over/Under 48.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

UPDATE 11 P.M. ET MONDAY: Jayden Daniels had his coming-out party in a Week 3 Monday night game. The rookie QB completed 21 of 23 passes for 254 yards and two TDs, leading Washington (2-1 SU and ATS) to a 38-33 upset as 7.5-point underdogs at Cincinnati.

Daniels ostensibly clinched the game with a 27-yard TD pass to Terry McLaurin to put the Commanders up 38-26 with 2:10 remaining.

In response, DraftKings Sportsbook moments ago reopened the Commanders-Cardinals game at Arizona -3. The line then settled in at Arizona -3.5, down notably from Sunday's -4.5 opener and this afternoon's -5.5 high point.

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Still, the Cards are landing 80% of early spread tickets/93% of early spread money.

UPDATE 10 P.M. ET SUNDAY: Arizona (1-2 SU/2-1 ATS) put up 28 and 41 points, respectively, in Weeks 1 and 2. The Cardinals had no such scoring output in Week 3, losing to Detroit 20-13 as 3-point home pups.

Washington (1-1 SU and ATS) still has a Week 3 hurdle to clear before focusing on Arizona. The Commanders visit Cincinnati on Monday night.

Commanders-Cardinals opened at Arizona -6 and dipped to -6.5 tonight in The SuperBook's NFL Week 4 odds. The total nudged from 48.5 to 49.

New England Patriots vs San Francisco 49ers Odds

• Opening point spread: 49ers -10.5
• Opening moneyline: 49ers -600/Patriots +450
• Opening total: Over/Under 40 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

UPDATE 10 P.M. ET SUNDAY: San Francisco (1-2 SU and ATS) was without Christian McCaffrey, Deebo Samuel and George Kittle in Week 3. It looked like the 49ers would overcome all that as 6-point road favorites vs. the Los Angeles Rams.

San Fran led 21-7 midway through the fourth quarter. But the Niners were outscored 20-3 from there, losing 27-24 on a final-seconds field goal.

New England (1-2 SU/1-1-1 ATS) had nothing for the New York Jets in the Week 3 Thursday nighter. The Patriots lost 24-3 catching 6.5 points on the road. Quarterback Jacoby Brissett was ineffective, getting sacked five times while going 12 of 18 for 98 yards.

Patriots rookie QB Drake Maye got mop-up duty in the final four minutes. But that doesn't mean he'll start in Week 4. New England coach Jerod Mayo hasn't yet made that decision.

The Patriots-49ers spread and total are stable tonight in The SuperBook's odds for NFL Week 4.

Kansas City Chiefs vs Los Angeles Chargers Odds

• Opening point spread: Chiefs -9.5
• Opening moneyline: Chiefs -330/Chargers +270
• Opening total: Over/Under 39 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

UPDATE 8 P.M. ET TUESDAY: This line has seen a lot of movement early in DraftKings Sportsbook's NFL odds Week 4 market. Kansas City opened -9, got as low as -7 Monday morning, then climbed to -8.5 by this morning.

It's now Chiefs -8, and early point-spread action is dead even on tickets and money.

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DraftKings' total opened at 39.5, peaked at 40 Monday and is now 39. The Over is taking 71% of early tickets, but early cash is dead even.

UPDATE 10 P.M. ET SUNDAY: Kansas City (3-0 SU/2-1 ATS) had its hands full in the Week 3 Sunday nighter at Atlanta. But the Chiefs held on for a 22-17 victory as 3-point favorites.

Los Angeles (2-1 SU and ATS) fell to Pittsburgh 20-10 catching 2.5 points on the road. Further, Chargers QB Justin Herbert re-aggravated an ankle injury and didn't play in the fourth quarter.

That was enough for The SuperBook to open Kansas City -9.5, shortly before the Chiefs kicked off against the Falcons in the Week 2 Sunday nighter.

"Obviously, this all depends on the health of Justin Herbert. But at the moment, we're not expecting him to play, and this line reflects that," SuperBook risk supervisor Chase Michaelson said. "I have a sneaking suspicion we'll need the Chargers in this one."

Chiefs-Chargers came off the board once Chiefs-Falcons kicked off. Chiefs-Chargers will go back up Monday morning.

Cleveland Browns vs Las Vegas Raiders Odds

• Opening point spread: Browns -1.5
• Opening moneyline: Browns -115/Raiders -105
• Opening total: Over/Under 41.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

UPDATE 10 P.M. ET SUNDAY: Las Vegas (1-2 SU and ATS) suffered one of the more stunning losses in Week 3. The Raiders, 5.5-point home favorites against Carolina, dug themselves into a 33-7 hole by early in the fourth quarter and lost 36-22.

Similarly, Cleveland (1-2 SU and ATS) was dealt an upset at home laying 6.5 points against the New York Giants. The Browns lost 21-15, despite holding New York scoreless in the second half.

The SuperBook opened Browns-Raiders at Cleveland -1.5 tonight and is now down to -1. More notable, the total tumbled from 41.5 to 37.5, with several stops along the way.

Buffalo Bills vs Baltimore Ravens Odds

• Opening point spread: Ravens -2.5
• Opening moneyline: Ravens -140/Bills +120
• Opening total: Over/Under 45.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

UPDATE 1:30 P.M. ET TUESDAY: Josh Allen and the Bills (3-0 SU/2-1 ATS) showed out big in a Week 3 Monday night contest. Allen threw four TD passes, and Buffalo hammered Jacksonville 47-10 as 4.5-point home chalk.

During that blowout win, The SuperBook took this week's Bills-Ravens tilt off the board. Bills-Ravens went back up this morning, but it remained at the opening line of Baltimore -2.5 in the NFL odds Week 2 market.

UPDATE 10 P.M. ET SUNDAY: Baltimore (1-2 SU and ATS) finally nabbed its first win of the season. The Ravens closed as 1.5-point favorites at Dallas and stormed to a 28-6 lead by early in the third quarter.

But Lamar Jackson & Co. had to hold on for a 28-25 victory.

Buffalo (2-0 SU/1-1 ATS) isn't yet out of Week 3. The Bills host Jacksonville on Monday night.

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Bills-Ravens opened at Baltimore -2.5 in The SuperBook's NFL odds Week 4 market, with no movement tonight.

"We put this line up [at 2.5] because of a dominant Ravens performance in Arlington. And then the Ravens almost blew it," SuperBook risk supervisor Chase Michaelson said. "The Ravens could easily be 3-0, and these are two of the best teams in the AFC, as they have been for a while.

"Home team -2.5 in the NFL means teams of equal strength, which sounds right for this game."

Tennessee Titans vs Miami Dolphins Odds

• Opening point spread: Pick
• Opening moneyline: Dolphins -110/Titans -110
• Opening total: Over/Under 37.5 points scored
• Time: 7:30 p.m. ET Monday (ESPN)

UPDATE 10 P.M. ET SUNDAY: Miami (1-2 SU/0-3 ATS) is in a world of hurt without QB Tua Tagovailoa, who has missed two games and will miss a few more, at least. To make matters worse, Skylar Thompson suffered a third-quarter chest injury Sunday at Seattle.

The Dolphins lost 24-3 getting 4 points and now have Tim Boyle under center.

Tennessee (0-3 SU and ATS) didn't fare much better at home against Green Bay. The Titans closed as 3-point favorites, then fell into a 27-7 hole en route to a 30-14 loss.

Titans-Dolphins opened a pick 'em on The SuperBook's NFL Week 4 odds board. There's no movement tonight on the spread or total.

Seattle Seahawks vs Detroit Lions Odds

• Opening point spread: Lions -4.5
• Opening moneyline: Lions -220/Seahawks +190
• Opening total: Over/Under 47.5 points scored
• Time: 8:15 p.m. ET Monday (ABC)

UPDATE 10 P.M. ET SUNDAY: Detroit (2-1 SU and ATS) bounced back from its Week 2 home loss to Tampa Bay. The Lions didn't exactly light it up, with no second-half scoring, but beat Arizona 20-13 as 3-point road favorites.

In Week 4, Seattle (3-0 SU/1-1-1 ATS) is an underdog for the first time this season. The Seahawks rolled over Miami 24-3 laying 4 points at home in Week 3.

The SuperBook opened Seahawks-Lions at Detroit -4.5, with no early movement.

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"A 3-0 Seahawks team with a two-game division lead. Was anyone expecting that before the season started?" SuperBook risk supervisor Chase Michaelson said. "The market loves the Lions, and at home at night, everything will be tied to Detroit.

"But the Seahawks' defense has looked really good through three games. This will be their sternest test for sure."

In-Progress Games for NFL Week 4

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Completed Games for NFL Week 4

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson