Indianapolis Colts Odds
| Pos | Player | Status |
| TE | Drew Ogletree (Neck) | Out |
| WR | Anthony Gould (Foot) | Out |
| QB | Riley Leonard (Knee) | Questionable |
| QB | Riley Leonard (Knee) | Out |
| QB | Riley Leonard (Knee) | Questionable |
| QB | Daniel Jones (Achilles) | Out |
| Date | Opp | Close | Result | ATS/OU |
| Sep 7, 2025 | Dolphins | -1.5
/ 47 | Won 33-8 | Won /
Under |
| Sep 14, 2025 | Broncos | +1.5
/ 43.5 | Won 29-28 | Won /
Over |
| Sep 21, 2025 | @Titans | -6
/ 42.5 | Won 41-20 | Won /
Over |
| Sep 28, 2025 | @Rams | +3.5
/ 49.5 | Lost 20-27 | Lost /
Under |
| Oct 5, 2025 | Raiders | -7.5
/ 46.5 | Won 40-6 | Won /
Under |
| Oct 12, 2025 | Cardinals | -8.5
/ 46.5 | Won 31-27 | Lost /
Over |
| Oct 19, 2025 | @Chargers | +2.5
/ 49.5 | Won 38-24 | Won /
Over |
| Oct 26, 2025 | Titans | -14.5
/ 48 | Won 38-14 | Won /
Over |
| Nov 2, 2025 | @Steelers | -3
/ 51.5 | Lost 20-27 | Lost /
Under |
| Nov 9, 2025 | Falcons | -6.5
/ 48.5 | Won 31-25 | Lost /
Over |
| Nov 23, 2025 | @Chiefs | +4.5
/ 50 | Lost 20-23 | Won /
Under |
| Nov 30, 2025 | Texans | -3
/ 44.5 | Lost 16-20 | Lost /
Under |
| Dec 7, 2025 | @Jaguars | -2.5
/ 44.5 | Lost 19-36 | Lost /
Over |
| Dec 14, 2025 | @Seahawks | +12.5
/ 41.5 | Lost 16-18 | Won /
Under |
| Dec 22, 2025 | 49ers | +4.5
/ 46.5 | Lost 27-48 | Lost /
Over |
| Dec 28, 2025 | Jaguars | +4.5
/ 48.5 | Lost 17-23 | Lost /
Under |
| Jan 4, 2026 | @Texans | +9.5
/ 37.5 | Lost 30-38 | Won /
Over |
• 
